Q7A714 (TAGA_STAAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylmannosaminyltransferase
EC=2.4.1.187

Alternative name(s):
Major teichoic acid biosynthesis protein A
N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase
UDP-N-acetylmannosamine transferase

Gene names

Name:	tagA
Ordered Locus Names:	SA0592

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, a key lipid intermediate in the de novo synthesis of teichoic acid Potential.
Catalytic activity	UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol.
Pathway	Cell wall biogenesis; poly(glycerol phosphate) teichoic acid biosynthesis.
Subcellular location	Secreted › cell wall By similarity.
Sequence similarities	Belongs to the glycosyltransferase 26 family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Teichoic acid biosynthesis
Cellular component	Secreted
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Putative N-acetylmannosaminyltransferase		PRO_0000208443

Sequences

	Sequence		Length	Mass (Da)
	Q7A714 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 99C014388CFED0BB	FASTA	254	29,133
	10 20 30 40 50 60 MTVEERSNTA KVDILGVDFD NTTMLQMVEN IKTFFANQST NNLFIVTANP EIVNYATTHQ 70 80 90 100 110 120 AYLELINQAS YIVADGTGVV KASHRLKQPL AHRIPGIELM DECLKIAHVN HQKVFLLGAT 130 140 150 160 170 180 NEVVEAAQYA LQQRYPNISF AHHHGYIDLE DETVVKRIKL FKPDYIFVGM GFPKQEEWIM 190 200 210 220 230 240 THENQFESTV MMGVGGSLEV FAGAKKRAPY IFRKLNIEWI YRALIDWKRI GRLKSIPIFM 250 YKIAKAKRKI KKAK

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: N315.

[2]

"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315." Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F. Submitted (OCT-2007) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Strain: N315.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000018 Genomic DNA. Translation: BAB41824.1.
PIR	E89833.
RefSeq	NP_373846.1. NC_002745.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7A714.
Protein family/group databases
CAZy	GT26. Glycosyltransferase Family 26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000001123; EBSTAP00000001123; EBSTAG00000001123.
GeneID	1123398.
GenomeReviews	Gene locus SA0592 in contig BA000018_GR.
KEGG	sau:SA0592.
PATRIC	19573306. VBIStaAur116463_0623.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1922.
GeneTree	EBGT00050000025549.
HOGENOM	HBG685240.
OMA	ENFIQNN.
ProtClustDB	CLSK884777.
Enzyme and pathway databases
BioCyc	SAUR158879:SA0592-MONOMER.
Family and domain databases
InterPro	IPR004629. WecB_TagA_CpsF. [Graphical view]
KO	K05946.
Pfam	PF03808. Glyco_tran_WecB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00696. WecB_tagA_cpsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TAGA_STAAN

Accession

Primary (citable) accession number: Q7A714

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program