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Protein

N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase

Gene

tarA

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosamine + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol.UniRule annotation

Pathwayi: poly(ribitol phosphate) teichoic acid biosynthesis

This protein is involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis, which is part of Cell wall biogenesis.Curated
View all proteins of this organism that are known to be involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation, Teichoic acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00790.

Protein family/group databases

CAZyiGT26. Glycosyltransferase Family 26.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferaseUniRule annotation (EC:2.4.1.187UniRule annotation)
Alternative name(s):
N-acetylmannosaminyltransferaseUniRule annotation
UDP-N-acetylmannosamine transferaseUniRule annotation
UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferaseUniRule annotation
Gene namesi
Name:tarA
Ordered Locus Names:SA0592
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084431 – 254N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferaseAdd BLAST254

Structurei

3D structure databases

SMRiQ7A714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000075379.
KOiK05946.
OMAiPWRWRRM.

Family and domain databases

CDDicd06533. Glyco_transf_WecG_TagA. 1 hit.
HAMAPiMF_02070. TagA_TarA. 1 hit.
InterProiView protein in InterPro
IPR034714. TagA_TarA.
IPR004629. WecB_TagA_CpsF.
PANTHERiPTHR34136. PTHR34136. 1 hit.
PfamiView protein in Pfam
PF03808. Glyco_tran_WecB. 1 hit.
TIGRFAMsiTIGR00696. wecG_tagA_cpsF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7A714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVEERSNTA KVDILGVDFD NTTMLQMVEN IKTFFANQST NNLFIVTANP
60 70 80 90 100
EIVNYATTHQ AYLELINQAS YIVADGTGVV KASHRLKQPL AHRIPGIELM
110 120 130 140 150
DECLKIAHVN HQKVFLLGAT NEVVEAAQYA LQQRYPNISF AHHHGYIDLE
160 170 180 190 200
DETVVKRIKL FKPDYIFVGM GFPKQEEWIM THENQFESTV MMGVGGSLEV
210 220 230 240 250
FAGAKKRAPY IFRKLNIEWI YRALIDWKRI GRLKSIPIFM YKIAKAKRKI

KKAK
Length:254
Mass (Da):29,133
Last modified:July 5, 2004 - v1
Checksum:i99C014388CFED0BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41824.1.
PIRiE89833.
RefSeqiWP_000215388.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41824; BAB41824; BAB41824.
KEGGisau:SA0592.

Similar proteinsi

Entry informationi

Entry nameiTARA_STAAN
AccessioniPrimary (citable) accession number: Q7A714
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome