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Q7A6F8

- FABF_STAAN

UniProt

Q7A6F8 - FABF_STAAN

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

Catalytic activityi

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651PROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-889-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase II
Beta-ketoacyl-ACP synthase II
Short name:
KAS II
Gene namesi
Name:fabF
Ordered Locus Names:SA0843
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4144143-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180322Add
BLAST

Proteomic databases

PRIDEiQ7A6F8.

2D gel databases

SWISS-2DPAGEQ7A6F8.

Interactioni

Protein-protein interaction databases

STRINGi158879.SA0843.

Structurei

3D structure databases

ProteinModelPortaliQ7A6F8.
SMRiQ7A6F8. Positions 4-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK09458.
OMAiNPDEVQY.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000447. KAS_II. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR03150. fabF. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A6F8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQNKRVVIT GMGALSPIGN DVKTTWENAL KGVNGIDKIT RIDTEPYSVH
60 70 80 90 100
LAGELKNFNI EDHIDKKEAR RMDRFTQYAI VAAREAVKDA QLDINDNTAD
110 120 130 140 150
RIGVWIGSGI GGMETFEIAH KQLMDKGPRR VSPFFVPMLI PDMATGQVSI
160 170 180 190 200
DLGAKGPNGA TVTACATGTN SIGEAFKIVQ RGDADAMITG GTEAPITHMA
210 220 230 240 250
IAGFSASRAL STNDDIETAC RPFQEGRDGF VMGEGAGILV IESLESAQAR
260 270 280 290 300
GANIYAEIVG YGTTGDAYHI TAPAPEGEGG SRAMQAAMDD AGIEPKDVQY
310 320 330 340 350
LNAHGTSTPV GDLNEVKAIK NTFGEAAKHL KVSSTKSMTG HLLGATGGIE
360 370 380 390 400
AIFSALSIKD SKVAPTIHAV TPDPECDLDI VPNEAQDLDI TYAMSNSLGF
410
GGHNAVLVFK KFEA
Length:414
Mass (Da):43,725
Last modified:July 5, 2004 - v1
Checksum:i46C0005B584824C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB42084.1.
PIRiA89866.
RefSeqiNP_374106.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42084; BAB42084; BAB42084.
GeneIDi1123660.
KEGGisau:SA0843.
PATRICi19573854. VBIStaAur116463_0899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB42084.1 .
PIRi A89866.
RefSeqi NP_374106.1. NC_002745.2.

3D structure databases

ProteinModelPortali Q7A6F8.
SMRi Q7A6F8. Positions 4-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA0843.

2D gel databases

SWISS-2DPAGE Q7A6F8.

Proteomic databases

PRIDEi Q7A6F8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB42084 ; BAB42084 ; BAB42084 .
GeneIDi 1123660.
KEGGi sau:SA0843.
PATRICi 19573854. VBIStaAur116463_0899.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060166.
KOi K09458.
OMAi NPDEVQY.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci SAUR158879:GJCB-889-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000447. KAS_II. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR03150. fabF. 1 hit.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.
  3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiFABF_STAAN
AccessioniPrimary (citable) accession number: Q7A6F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3