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Q7A654

- ISDC_STAAN

UniProt

Q7A654 - ISDC_STAAN

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Protein

Iron-regulated surface determinant protein C

Gene

isdC

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471HemeBy similarity
Binding sitei48 – 481Heme; via amide nitrogenBy similarity
Metal bindingi132 – 1321Iron (heme axial ligand)By similarity
Binding sitei136 – 1361HemeBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-regulated surface determinant protein C
Alternative name(s):
Staphylococcal iron-regulated protein D
Gene namesi
Name:isdC
Synonyms:sirD
Ordered Locus Names:SA0978
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Subcellular locationi

Secretedcell wall By similarity; Peptidoglycan-anchor By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. peptidoglycan-based cell wall Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 192164Iron-regulated surface determinant protein CPRO_0000019446Add
BLAST
Propeptidei193 – 22735Removed by sortase BBy similarityPRO_0000019447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921Pentaglycyl murein peptidoglycan amidated threonineBy similarity

Keywords - PTMi

Peptidoglycan-anchor

Expressioni

Inductioni

Repressed by fur in the presence of iron.By similarity

Interactioni

Subunit structurei

Monomer. Interacts with IsdA (By similarity).By similarity

Protein-protein interaction databases

STRINGi158879.SA0978.

Structurei

3D structure databases

ProteinModelPortaliQ7A654.
SMRiQ7A654. Positions 25-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 150122NEATPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi189 – 1935NPQTN sorting signal

Domaini

The NEAT domain binds Fe3+ heme iron. Reduction of the high-spin Fe3+ heme iron to high-spin Fe2+ results in loss of the heme from the binding site of the protein due to the absence of a proximal histidine (By similarity).By similarity

Sequence similaritiesi

Belongs to the IsdC family.Curated
Contains 1 NEAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5386.
HOGENOMiHOG000059157.
OMAiIRKVRQN.
OrthoDBiEOG68SVXG.

Family and domain databases

InterProiIPR019909. Haem_uptake_protein_IsdC.
IPR006635. NEAT_dom.
IPR017505. Sortase_SrtB_sig_NPQTN.
[Graphical view]
PfamiPF05031. NEAT. 1 hit.
[Graphical view]
SMARTiSM00725. NEAT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03656. IsdC. 1 hit.
TIGR03068. srtB_sig_NPQTN. 1 hit.
PROSITEiPS50978. NEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7A654-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNILKVFNT TILALIIIIA TFSNSANAAD SGTLNYEVYK YNTNDTSIAN
60 70 80 90 100
DYFNKPAKYI KKNGKLYVQI TVNHSHWITG MSIEGHKENI ISKNTAKDER
110 120 130 140 150
TSEFEVSKLN GKIDGKIDVY IDEKVNGKPF KYDHHYNITY KFNGPTDVAG
160 170 180 190 200
ANAPGKDDKN SASGSDKGSD GTTTGQSESN SSNKDKVENP QTNAGTPAYI
210 220
YAIPVASLAL LIAITLFVRK KSKGNVE
Length:227
Mass (Da):24,855
Last modified:July 5, 2004 - v1
Checksum:i38ABDD96F954B05A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42227.1.
PIRiG89883.
RefSeqiNP_374248.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42227; BAB42227; BAB42227.
GeneIDi1123805.
KEGGisau:SA0978.
PATRICi19574152. VBIStaAur116463_1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42227.1 .
PIRi G89883.
RefSeqi NP_374248.1. NC_002745.2.

3D structure databases

ProteinModelPortali Q7A654.
SMRi Q7A654. Positions 25-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA0978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB42227 ; BAB42227 ; BAB42227 .
GeneIDi 1123805.
KEGGi sau:SA0978.
PATRICi 19574152. VBIStaAur116463_1046.

Phylogenomic databases

eggNOGi COG5386.
HOGENOMi HOG000059157.
OMAi IRKVRQN.
OrthoDBi EOG68SVXG.

Enzyme and pathway databases

BioCyci SAUR158879:GJCB-1034-MONOMER.

Family and domain databases

InterProi IPR019909. Haem_uptake_protein_IsdC.
IPR006635. NEAT_dom.
IPR017505. Sortase_SrtB_sig_NPQTN.
[Graphical view ]
Pfami PF05031. NEAT. 1 hit.
[Graphical view ]
SMARTi SM00725. NEAT. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03656. IsdC. 1 hit.
TIGR03068. srtB_sig_NPQTN. 1 hit.
PROSITEi PS50978. NEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiISDC_STAAN
AccessioniPrimary (citable) accession number: Q7A654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3