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Q7A654

- ISDC_STAAN

UniProt

Q7A654 - ISDC_STAAN

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Protein
Iron-regulated surface determinant protein C
Gene
isdC, sirD, SA0978
Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471Heme By similarity
Binding sitei48 – 481Heme; via amide nitrogen By similarity
Metal bindingi132 – 1321Iron (heme axial ligand) By similarity
Binding sitei136 – 1361Heme By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-regulated surface determinant protein C
Alternative name(s):
Staphylococcal iron-regulated protein D
Gene namesi
Name:isdC
Synonyms:sirD
Ordered Locus Names:SA0978
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. peptidoglycan-based cell wall Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 192164Iron-regulated surface determinant protein C
PRO_0000019446Add
BLAST
Propeptidei193 – 22735Removed by sortase B By similarity
PRO_0000019447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921Pentaglycyl murein peptidoglycan amidated threonine By similarity

Keywords - PTMi

Peptidoglycan-anchor

Expressioni

Inductioni

Repressed by fur in the presence of iron By similarity.

Interactioni

Subunit structurei

Monomer. Interacts with IsdA By similarity.

Protein-protein interaction databases

STRINGi158879.SA0978.

Structurei

3D structure databases

ProteinModelPortaliQ7A654.
SMRiQ7A654. Positions 25-149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 150122NEAT
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi189 – 1935NPQTN sorting signal

Domaini

The NEAT domain binds Fe3+ heme iron. Reduction of the high-spin Fe3+ heme iron to high-spin Fe2+ results in loss of the heme from the binding site of the protein due to the absence of a proximal histidine By similarity.

Sequence similaritiesi

Belongs to the IsdC family.
Contains 1 NEAT domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5386.
HOGENOMiHOG000059157.
OMAiIRKVRQN.
OrthoDBiEOG68SVXG.

Family and domain databases

InterProiIPR019909. Haem_uptake_protein_IsdC.
IPR006635. NEAT_dom.
IPR017505. Sortase_SrtB_sig_NPQTN.
[Graphical view]
PfamiPF05031. NEAT. 1 hit.
[Graphical view]
SMARTiSM00725. NEAT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03656. IsdC. 1 hit.
TIGR03068. srtB_sig_NPQTN. 1 hit.
PROSITEiPS50978. NEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7A654-1 [UniParc]FASTAAdd to Basket

« Hide

MKNILKVFNT TILALIIIIA TFSNSANAAD SGTLNYEVYK YNTNDTSIAN    50
DYFNKPAKYI KKNGKLYVQI TVNHSHWITG MSIEGHKENI ISKNTAKDER 100
TSEFEVSKLN GKIDGKIDVY IDEKVNGKPF KYDHHYNITY KFNGPTDVAG 150
ANAPGKDDKN SASGSDKGSD GTTTGQSESN SSNKDKVENP QTNAGTPAYI 200
YAIPVASLAL LIAITLFVRK KSKGNVE 227
Length:227
Mass (Da):24,855
Last modified:July 5, 2004 - v1
Checksum:i38ABDD96F954B05A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB42227.1.
PIRiG89883.
RefSeqiNP_374248.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42227; BAB42227; BAB42227.
GeneIDi1123805.
KEGGisau:SA0978.
PATRICi19574152. VBIStaAur116463_1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB42227.1 .
PIRi G89883.
RefSeqi NP_374248.1. NC_002745.2.

3D structure databases

ProteinModelPortali Q7A654.
SMRi Q7A654. Positions 25-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA0978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB42227 ; BAB42227 ; BAB42227 .
GeneIDi 1123805.
KEGGi sau:SA0978.
PATRICi 19574152. VBIStaAur116463_1046.

Phylogenomic databases

eggNOGi COG5386.
HOGENOMi HOG000059157.
OMAi IRKVRQN.
OrthoDBi EOG68SVXG.

Enzyme and pathway databases

BioCyci SAUR158879:GJCB-1034-MONOMER.

Family and domain databases

InterProi IPR019909. Haem_uptake_protein_IsdC.
IPR006635. NEAT_dom.
IPR017505. Sortase_SrtB_sig_NPQTN.
[Graphical view ]
Pfami PF05031. NEAT. 1 hit.
[Graphical view ]
SMARTi SM00725. NEAT. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03656. IsdC. 1 hit.
TIGR03068. srtB_sig_NPQTN. 1 hit.
PROSITEi PS50978. NEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiISDC_STAAN
AccessioniPrimary (citable) accession number: Q7A654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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