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Q7A654

- ISDC_STAAN

UniProt

Q7A654 - ISDC_STAAN

Protein

Iron-regulated surface determinant protein C

Gene

isdC

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei47 – 471HemeBy similarity
    Binding sitei48 – 481Heme; via amide nitrogenBy similarity
    Metal bindingi132 – 1321Iron (heme axial ligand)By similarity
    Binding sitei136 – 1361HemeBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme transport Source: InterPro

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-1034-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iron-regulated surface determinant protein C
    Alternative name(s):
    Staphylococcal iron-regulated protein D
    Gene namesi
    Name:isdC
    Synonyms:sirD
    Ordered Locus Names:SA0978
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    Subcellular locationi

    Secretedcell wall By similarity; Peptidoglycan-anchor By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-KW
    2. peptidoglycan-based cell wall Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 192164Iron-regulated surface determinant protein CPRO_0000019446Add
    BLAST
    Propeptidei193 – 22735Removed by sortase BBy similarityPRO_0000019447Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei192 – 1921Pentaglycyl murein peptidoglycan amidated threonineBy similarity

    Keywords - PTMi

    Peptidoglycan-anchor

    Expressioni

    Inductioni

    Repressed by fur in the presence of iron.By similarity

    Interactioni

    Subunit structurei

    Monomer. Interacts with IsdA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi158879.SA0978.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7A654.
    SMRiQ7A654. Positions 25-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 150122NEATPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi189 – 1935NPQTN sorting signal

    Domaini

    The NEAT domain binds Fe3+ heme iron. Reduction of the high-spin Fe3+ heme iron to high-spin Fe2+ results in loss of the heme from the binding site of the protein due to the absence of a proximal histidine By similarity.By similarity

    Sequence similaritiesi

    Belongs to the IsdC family.Curated
    Contains 1 NEAT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5386.
    HOGENOMiHOG000059157.
    OMAiIRKVRQN.
    OrthoDBiEOG68SVXG.

    Family and domain databases

    InterProiIPR019909. Haem_uptake_protein_IsdC.
    IPR006635. NEAT_dom.
    IPR017505. Sortase_SrtB_sig_NPQTN.
    [Graphical view]
    PfamiPF05031. NEAT. 1 hit.
    [Graphical view]
    SMARTiSM00725. NEAT. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03656. IsdC. 1 hit.
    TIGR03068. srtB_sig_NPQTN. 1 hit.
    PROSITEiPS50978. NEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7A654-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNILKVFNT TILALIIIIA TFSNSANAAD SGTLNYEVYK YNTNDTSIAN    50
    DYFNKPAKYI KKNGKLYVQI TVNHSHWITG MSIEGHKENI ISKNTAKDER 100
    TSEFEVSKLN GKIDGKIDVY IDEKVNGKPF KYDHHYNITY KFNGPTDVAG 150
    ANAPGKDDKN SASGSDKGSD GTTTGQSESN SSNKDKVENP QTNAGTPAYI 200
    YAIPVASLAL LIAITLFVRK KSKGNVE 227
    Length:227
    Mass (Da):24,855
    Last modified:July 5, 2004 - v1
    Checksum:i38ABDD96F954B05A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42227.1.
    PIRiG89883.
    RefSeqiNP_374248.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB42227; BAB42227; BAB42227.
    GeneIDi1123805.
    KEGGisau:SA0978.
    PATRICi19574152. VBIStaAur116463_1046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42227.1 .
    PIRi G89883.
    RefSeqi NP_374248.1. NC_002745.2.

    3D structure databases

    ProteinModelPortali Q7A654.
    SMRi Q7A654. Positions 25-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA0978.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB42227 ; BAB42227 ; BAB42227 .
    GeneIDi 1123805.
    KEGGi sau:SA0978.
    PATRICi 19574152. VBIStaAur116463_1046.

    Phylogenomic databases

    eggNOGi COG5386.
    HOGENOMi HOG000059157.
    OMAi IRKVRQN.
    OrthoDBi EOG68SVXG.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-1034-MONOMER.

    Family and domain databases

    InterProi IPR019909. Haem_uptake_protein_IsdC.
    IPR006635. NEAT_dom.
    IPR017505. Sortase_SrtB_sig_NPQTN.
    [Graphical view ]
    Pfami PF05031. NEAT. 1 hit.
    [Graphical view ]
    SMARTi SM00725. NEAT. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03656. IsdC. 1 hit.
    TIGR03068. srtB_sig_NPQTN. 1 hit.
    PROSITEi PS50978. NEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.

    Entry informationi

    Entry nameiISDC_STAAN
    AccessioniPrimary (citable) accession number: Q7A654
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3