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Q7A654 (ISDC_STAAN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iron-regulated surface determinant protein C
Alternative name(s):
Staphylococcal iron-regulated protein D
Gene names
Name:isdC
Synonyms:sirD
Ordered Locus Names:SA0978
OrganismStaphylococcus aureus (strain N315) [Complete proteome] [HAMAP]
Taxonomic identifier158879 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible By similarity.

Subunit structure

Monomer. Interacts with IsdA By similarity.

Subcellular location

Secretedcell wall; Peptidoglycan-anchor By similarity.

Induction

Repressed by fur in the presence of iron By similarity.

Domain

The NEAT domain binds Fe3+ heme iron. Reduction of the high-spin Fe3+ heme iron to high-spin Fe2+ results in loss of the heme from the binding site of the protein due to the absence of a proximal histidine By similarity.

Sequence similarities

Belongs to the IsdC family.

Contains 1 NEAT domain.

Ontologies

Keywords
   Cellular componentCell wall
Secreted
   DomainSignal
   LigandHeme
Iron
Metal-binding
   PTMPeptidoglycan-anchor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

peptidoglycan-based cell wall

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 192164Iron-regulated surface determinant protein C
PRO_0000019446
Propeptide193 – 22735Removed by sortase B By similarity
PRO_0000019447

Regions

Domain29 – 150122NEAT
Motif189 – 1935NPQTN sorting signal

Sites

Metal binding1321Iron (heme axial ligand) By similarity
Binding site471Heme By similarity
Binding site481Heme; via amide nitrogen By similarity
Binding site1361Heme By similarity

Amino acid modifications

Modified residue1921Pentaglycyl murein peptidoglycan amidated threonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7A654 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 38ABDD96F954B05A

FASTA22724,855
        10         20         30         40         50         60 
MKNILKVFNT TILALIIIIA TFSNSANAAD SGTLNYEVYK YNTNDTSIAN DYFNKPAKYI 

        70         80         90        100        110        120 
KKNGKLYVQI TVNHSHWITG MSIEGHKENI ISKNTAKDER TSEFEVSKLN GKIDGKIDVY 

       130        140        150        160        170        180 
IDEKVNGKPF KYDHHYNITY KFNGPTDVAG ANAPGKDDKN SASGSDKGSD GTTTGQSESN 

       190        200        210        220 
SSNKDKVENP QTNAGTPAYI YAIPVASLAL LIAITLFVRK KSKGNVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000018 Genomic DNA. Translation: BAB42227.1.
PIRG89883.
RefSeqNP_374248.1. NC_002745.2.

3D structure databases

ProteinModelPortalQ7A654.
SMRQ7A654. Positions 25-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING158879.SA0978.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB42227; BAB42227; BAB42227.
GeneID1123805.
KEGGsau:SA0978.
PATRIC19574152. VBIStaAur116463_1046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG5386.
HOGENOMHOG000059157.
OMAMPYGKVS.
OrthoDBEOG68SVXG.
ProtClustDBCLSK885154.

Enzyme and pathway databases

BioCycSAUR158879:GJCB-1034-MONOMER.

Family and domain databases

InterProIPR019909. Haem_uptake_protein_IsdC.
IPR006635. NEA_transpt.
IPR017505. Sortase_SrtB_sig_NPQTN.
[Graphical view]
PfamPF05031. NEAT. 1 hit.
[Graphical view]
SMARTSM00725. NEAT. 1 hit.
[Graphical view]
TIGRFAMsTIGR03656. IsdC. 1 hit.
TIGR03068. srtB_sig_NPQTN. 1 hit.
PROSITEPS50978. NEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISDC_STAAN
AccessionPrimary (citable) accession number: Q7A654
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: November 13, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families