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Protein
Submitted name:

Protein kinase

Gene

SA1063

Organism
Staphylococcus aureus (strain N315)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391ATP analogCombined sources
Binding sitei90 – 901ATP analog; via amide nitrogenCombined sources
Binding sitei150 – 1501ATP analogCombined sources
Metal bindingi429 – 4291ZincCombined sources
Metal bindingi432 – 4321ZincCombined sources

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. penicillin binding Source: InterPro
  4. protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

Metal-bindingCombined sources, Nucleotide-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1123-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinaseImported
Gene namesi
Ordered Locus Names:SA1063Imported
OrganismiStaphylococcus aureus (strain N315)Imported
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi158879.SA1063.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M9GX-ray2.90A376-576[»]
4EQMX-ray3.00A/B/C/D/E/F1-291[»]
ProteinModelPortaliQ7A5Z8.
SMRiQ7A5Z8. Positions 1-282, 376-662.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7A5Z8.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037186.
KOiK08884.
OMAiMQIPIVN.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 3 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51178. PASTA. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A5Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGKIINERY KIVDKLGGGG MSTVYLAEDT ILNIKVAIKA IFIPPREKEE
60 70 80 90 100
TLKRFEREVH NSSQLSHQNI VSMIDVDEED DCYYLVMEYI EGPTLSEYIE
110 120 130 140 150
SHGPLSVDTA INFTNQILDG IKHAHDMRIV HRDIKPQNIL IDSNKTLKIF
160 170 180 190 200
DFGIAKALSE TSLTQTNHVL GTVQYFSPEQ AKGEATDECT DIYSIGIVLY
210 220 230 240 250
EMLVGEPPFN GETAVSIAIK HIQDSVPNVT TDVRKDIPQS LSNVILRATE
260 270 280 290 300
KDKANRYKTI QEMKDDLSSV LHENRANEDV YELDKMKTIA VPLKKEDLAK
310 320 330 340 350
HISEHKSNQP KRETTQVPIV NGPAHHQQFQ KPEGTVYEPK PKKKSTRKIV
360 370 380 390 400
LLSLIFSLLM IALVSFVAMA MFGNKYEETP DVIGKSVKEA EQIFNKNNLK
410 420 430 440 450
LGKISRSYSD KYPENEIIKT TPNTGERVER GDSVDVVISK GPEKVKMPNV
460 470 480 490 500
IGLPKEEALQ KLKSLGLKDV TIEKVYNNQA PKGYIANQSV TANTEIAIHD
510 520 530 540 550
SNIKLYESLG IKQVYVEDFE HKSFSKAKKA LEEKGFKVES KEEYSDDIDE
560 570 580 590 600
GDVISQSPKG KSVDEGSTIS FVVSKGKKSD SSDVKTTTES VDVPYTGKND
610 620 630 640 650
KSQKVKVYIK DKDNDGSTEK GSFDITSDQR IDIPLRIEKG KTASYIVKVD
660
GKTVAEKEVS YDDI
Length:664
Mass (Da):74,377
Last modified:July 5, 2004 - v1
Checksum:i3461386C5DB61828
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42315.1.
RefSeqiNP_374336.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42315; BAB42315; BAB42315.
KEGGisau:SA1063.
PATRICi19574346. VBIStaAur116463_1142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42315.1.
RefSeqiNP_374336.1. NC_002745.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M9GX-ray2.90A376-576[»]
4EQMX-ray3.00A/B/C/D/E/F1-291[»]
ProteinModelPortaliQ7A5Z8.
SMRiQ7A5Z8. Positions 1-282, 376-662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158879.SA1063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB42315; BAB42315; BAB42315.
KEGGisau:SA1063.
PATRICi19574346. VBIStaAur116463_1142.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037186.
KOiK08884.
OMAiMQIPIVN.
OrthoDBiEOG6B35XT.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1123-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ7A5Z8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 3 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51178. PASTA. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315Imported.
  2. "The extended conformation of the 2.9-A crystal structure of the three-PASTA domain of a Ser/Thr kinase from the human pathogen Staphylococcus aureus."
    Paracuellos P., Ballandras A., Robert X., Kahn R., Herve M., Mengin-Lecreulx D., Cozzone A.J., Duclos B., Gouet P.
    J. Mol. Biol. 404:847-858(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 376-576 IN COMPLEX WITH ZINC.
  3. "Structural analysis of Staphylococcus aureus serine/threonine kinase PknB."
    Rakette S., Donat S., Ohlsen K., Stehle T.
    PLoS ONE 7:e39136-e39136(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-291 IN COMPLEX WITH ATP ANALOG.

Entry informationi

Entry nameiQ7A5Z8_STAAN
AccessioniPrimary (citable) accession number: Q7A5Z8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.