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Q7A5Z8

- Q7A5Z8_STAAN

UniProt

Q7A5Z8 - Q7A5Z8_STAAN

Protein
Submitted name:

Protein kinase

Gene

SA1063

Organism
Staphylococcus aureus (strain N315)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391ATPanalogImported
    Binding sitei90 – 901ATPanalog; via amide nitrogenImported
    Binding sitei150 – 1501ATPanalogImported
    Metal bindingi429 – 4291Zinc
    Metal bindingi432 – 4321Zinc

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. penicillin binding Source: InterPro
    4. protein serine/threonine kinase activity Source: InterPro

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Keywords - Ligandi

    Metal-bindingImported, Nucleotide-bindingImported, ZincImported

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-1123-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein kinaseImported
    Gene namesi
    Ordered Locus Names:SA1063Imported
    OrganismiStaphylococcus aureus (strain N315)Imported
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    PTM / Processingi

    PTM databases

    PhosSiteiP0909763.

    Interactioni

    Protein-protein interaction databases

    STRINGi158879.SA1063.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3M9GX-ray2.90A376-576[»]
    4EQMX-ray3.00A/B/C/D/E/F1-291[»]
    ProteinModelPortaliQ7A5Z8.
    SMRiQ7A5Z8. Positions 1-282, 376-662.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7A5Z8.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000037186.
    KOiK08884.
    OMAiMQIPIVN.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF03793. PASTA. 3 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00740. PASTA. 3 hits.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51178. PASTA. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7A5Z8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGKIINERY KIVDKLGGGG MSTVYLAEDT ILNIKVAIKA IFIPPREKEE    50
    TLKRFEREVH NSSQLSHQNI VSMIDVDEED DCYYLVMEYI EGPTLSEYIE 100
    SHGPLSVDTA INFTNQILDG IKHAHDMRIV HRDIKPQNIL IDSNKTLKIF 150
    DFGIAKALSE TSLTQTNHVL GTVQYFSPEQ AKGEATDECT DIYSIGIVLY 200
    EMLVGEPPFN GETAVSIAIK HIQDSVPNVT TDVRKDIPQS LSNVILRATE 250
    KDKANRYKTI QEMKDDLSSV LHENRANEDV YELDKMKTIA VPLKKEDLAK 300
    HISEHKSNQP KRETTQVPIV NGPAHHQQFQ KPEGTVYEPK PKKKSTRKIV 350
    LLSLIFSLLM IALVSFVAMA MFGNKYEETP DVIGKSVKEA EQIFNKNNLK 400
    LGKISRSYSD KYPENEIIKT TPNTGERVER GDSVDVVISK GPEKVKMPNV 450
    IGLPKEEALQ KLKSLGLKDV TIEKVYNNQA PKGYIANQSV TANTEIAIHD 500
    SNIKLYESLG IKQVYVEDFE HKSFSKAKKA LEEKGFKVES KEEYSDDIDE 550
    GDVISQSPKG KSVDEGSTIS FVVSKGKKSD SSDVKTTTES VDVPYTGKND 600
    KSQKVKVYIK DKDNDGSTEK GSFDITSDQR IDIPLRIEKG KTASYIVKVD 650
    GKTVAEKEVS YDDI 664
    Length:664
    Mass (Da):74,377
    Last modified:July 5, 2004 - v1
    Checksum:i3461386C5DB61828
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42315.1.
    RefSeqiNP_374336.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB42315; BAB42315; BAB42315.
    GeneIDi1123894.
    KEGGisau:SA1063.
    PATRICi19574346. VBIStaAur116463_1142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB42315.1 .
    RefSeqi NP_374336.1. NC_002745.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3M9G X-ray 2.90 A 376-576 [» ]
    4EQM X-ray 3.00 A/B/C/D/E/F 1-291 [» ]
    ProteinModelPortali Q7A5Z8.
    SMRi Q7A5Z8. Positions 1-282, 376-662.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA1063.

    PTM databases

    PhosSitei P0909763.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB42315 ; BAB42315 ; BAB42315 .
    GeneIDi 1123894.
    KEGGi sau:SA1063.
    PATRICi 19574346. VBIStaAur116463_1142.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000037186.
    KOi K08884.
    OMAi MQIPIVN.
    OrthoDBi EOG6B35XT.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-1123-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q7A5Z8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF03793. PASTA. 3 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00740. PASTA. 3 hits.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51178. PASTA. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315Imported.
    2. "The extended conformation of the 2.9-A crystal structure of the three-PASTA domain of a Ser/Thr kinase from the human pathogen Staphylococcus aureus."
      Paracuellos P., Ballandras A., Robert X., Kahn R., Herve M., Mengin-Lecreulx D., Cozzone A.J., Duclos B., Gouet P.
      J. Mol. Biol. 404:847-858(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 376-576 IN COMPLEX WITH ZINC.
    3. "Structural analysis of Staphylococcus aureus serine/threonine kinase PknB."
      Rakette S., Donat S., Ohlsen K., Stehle T.
      PLoS ONE 7:e39136-e39136(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 1-291 IN COMPLEX WITH ATPANALOG.

    Entry informationi

    Entry nameiQ7A5Z8_STAAN
    AccessioniPrimary (citable) accession number: Q7A5Z8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3