Q7A5Y4 (CDSA_STAAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	SA1104

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Phosphatidate cytidylyltransferase		PRO_0000090749
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	46 – 66	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7A5Y4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 02C2727C3801C694	FASTA	260	28,964
	10 20 30 40 50 60 MKVRTLTAII ALIVFLPILL KGGLVLMIFA NILALIALKE LLNMNMIKFV SVPGLISAVG 70 80 90 100 110 120 LIIIMLPQHA GPWVQVIQLK SLIAMSFIVL SYTVLSKNRF SFMDAAFCLM SVAYVGIGFM 130 140 150 160 170 180 FFYETRSEGL HYILYAFLIV WLTDTGAYLF GKMMGKHKLW PVISPNKTIE GFIGGLFCSL 190 200 210 220 230 240 IVPLAMLYFV DFNMNVWILL GVTLILSLFG QLGDLVESGF KRHFGVKDSG RILPGHGGIL 250 260 DRFDSFMFVL PLLNILLIQS

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: N315.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000018 Genomic DNA. Translation: BAB42356.1.
PIR	H89899.
RefSeq	NP_374377.1. NC_002745.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7A5Y4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000000788; EBSTAP00000000788; EBSTAG00000000788.
GeneID	1123935.
GenomeReviews	Gene locus SA1104 in contig BA000018_GR.
KEGG	sau:SA1104.
PATRIC	19574428. VBIStaAur116463_1183.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0575.
GeneTree	EBGT00050000025310.
HOGENOM	HBG732679.
OMA	MRERFIW.
ProtClustDB	CLSK885236.
Enzyme and pathway databases
BioCyc	SAUR158879:SA1104-MONOMER.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_STAAN

Accession

Primary (citable) accession number: Q7A5Y4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program