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Protein

Aerobic glycerol-3-phosphate dehydrogenase

Gene

glpD

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Pathway:iglycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (aerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Aerobic glycerol-3-phosphate dehydrogenase (glpD)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (aerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 4929FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1203-MONOMER.
UniPathwayiUPA00618; UER00674.

Names & Taxonomyi

Protein namesi
Recommended name:
Aerobic glycerol-3-phosphate dehydrogenase (EC:1.1.5.3)
Gene namesi
Name:glpD
Ordered Locus Names:SA1142
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Aerobic glycerol-3-phosphate dehydrogenasePRO_0000270061Add
BLAST

Proteomic databases

PRIDEiQ7A5V7.

Structurei

3D structure databases

ProteinModelPortaliQ7A5V7.
SMRiQ7A5V7. Positions 3-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004812.
KOiK00111.
OrthoDBiEOG651SR7.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A5V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSTFKREH IKKNLRNDEY DLVIIGGGIT GAGIALDASE RGMKVALVEM
60 70 80 90 100
QDFAQGTSSR STKLVHGGLR YLKQFQIGVV AETGKERAIV YENGPHVTTP
110 120 130 140 150
EWMLLPMHKG GTFGKFSTSI GLGMYDRLAG VKKSERKKML SKKETLAKEP
160 170 180 190 200
LVKKEGLKGG GYYVEYRTDD ARLTIEVMKR AAEKGAEIIN YTKSEHFTYD
210 220 230 240 250
KNQQVNGVKV IDKLTNENYT IKAKKVVNAA GPWVDDVRSG DYARNNKKLR
260 270 280 290 300
LTKGVHVVID QSKFPLGQAV YFDTEKDGRM IFAIPREGKA YVGTTDTFYD
310 320 330 340 350
NIKSSPLTTQ EDRDYLIDAI NYMFPSVNVT DEDIESTWAG IRPLIYEEGK
360 370 380 390 400
DPSEISRKDE IWEGKSGLLT IAGGKLTGYR HMAQDIVDLV SKRLKKDYGL
410 420 430 440 450
TFSPCNTKGL AISGGDVGGS KNFDAFVEQK VDVAKGFGID EDVARRLASK
460 470 480 490 500
YGSNVDELFN IAQTSQYHDS KLPLEIYVEL VYSIQQEMVY KPNDFLVRRS
510 520 530 540 550
GKMYFNIKDV LDYKDAVIDI MADMLDYSPA QIEAYTEEVE QAIKEAQHGN

NQPAVKE
Length:557
Mass (Da):62,388
Last modified:January 9, 2007 - v2
Checksum:iBB3D044040212E82
GO

Sequence cautioni

The sequence BAB42396.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42396.1. Different initiation.
PIRiH89904.
RefSeqiWP_001218596.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42396; BAB42396; BAB42396.
KEGGisau:SA1142.
PATRICi19574508. VBIStaAur116463_1223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42396.1. Different initiation.
PIRiH89904.
RefSeqiWP_001218596.1. NC_002745.2.

3D structure databases

ProteinModelPortaliQ7A5V7.
SMRiQ7A5V7. Positions 3-546.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7A5V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB42396; BAB42396; BAB42396.
KEGGisau:SA1142.
PATRICi19574508. VBIStaAur116463_1223.

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004812.
KOiK00111.
OrthoDBiEOG651SR7.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00674.
BioCyciSAUR158879:GJCB-1203-MONOMER.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiGLPD_STAAN
AccessioniPrimary (citable) accession number: Q7A5V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 22, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.