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Reviewed, UniProtKB/Swiss-Prot Q7A5R7 (TYRA_STAAN)

Last modified January 19, 2010. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12
Gene names
Name: tyrA
Ordered Locus Names: SA1197
OrganismStaphylococcus aureus (strain N315) [Complete proteome] [HAMAP]
Taxonomic identifier158879 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existencePredicted.

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Prephenate dehydrogenase
PRO_0000282660

Regions

Domain2 – 291290Prephenate/arogenate dehydrogenase
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q7A5R7-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8867E851BCE816C6

FASTA36340,397
        10         20         30         40         50         60 
MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE KCLNYSEAIK 

        70         80         90        100        110        120 
KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA MIQQHESNLL KHNIHLVSGH 

       130        140        150        160        170        180 
PMAGSHKSGV LNAKKHLFEN AYYILVYNEP RNEQAANTLK ELLSPTLAKF IVTTAEEHDY 

       190        200        210        220        230        240 
VTSVVSHLPH IVASSLVHVS QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK 

       250        260        270        280        290        300 
TYILEMIRQL KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 

       310        320        330        340        350        360 
IPDESGMISK VTYIMSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER GMQALSDFDC 


YIQ 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000018 Genomic DNA. Translation: BAB42457.1.
PIRE89912.
RefSeqNP_374478.1.

3D structure databases

HSSPHSSP built from PDB template 2G5C based on UniProtKB O67636.
SMRQ7A5R7. Positions 3-295.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7A5R7.

Genome annotation databases

GeneID1124036.
GenomeReviewsGene locus SA1197 in contig BA000018_GR.
KEGGsau:SA1197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHBG544990.
OMAQRAIRWG.

Enzyme and pathway databases

BioCycSAUR158879:SA1197-MONOMER.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PANTHERPTHR21363. Prephen_DH. 1 hit.
PfamPF02153. PDH. 1 hit.
[Graphical view]
PROSITEPS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_STAAN
AccessionPrimary (citable) accession number: Q7A5R7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents