Q7A5R7 (TYRA_STAAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prephenate dehydrogenase
Short name=PDH
EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	SA1197

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
Sequence similarities	Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Prephenate dehydrogenase		PRO_0000282660
Regions
	Domain	2 – 291	290	Prephenate/arogenate dehydrogenase
	Nucleotide binding	3 – 33	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7A5R7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8867E851BCE816C6	FASTA	363	40,397
	10 20 30 40 50 60 MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE KCLNYSEAIK 70 80 90 100 110 120 KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA MIQQHESNLL KHNIHLVSGH 130 140 150 160 170 180 PMAGSHKSGV LNAKKHLFEN AYYILVYNEP RNEQAANTLK ELLSPTLAKF IVTTAEEHDY 190 200 210 220 230 240 VTSVVSHLPH IVASSLVHVS QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK 250 260 270 280 290 300 TYILEMIRQL KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 310 320 330 340 350 360 IPDESGMISK VTYIMSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER GMQALSDFDC YIQ

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: N315.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000018 Genomic DNA. Translation: BAB42457.1.
PIR	E89912.
RefSeq	NP_374478.1. NC_002745.2.
3D structure databases
ProteinModelPortal	Q7A5R7.
SMR	Q7A5R7. Positions 3-283.
ModBase	Search...
Protein-protein interaction databases
STRING	158879.SA1197.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB42457; BAB42457; BAB42457.
GeneID	1124036.
KEGG	sau:SA1197.
PATRIC	19574644. VBIStaAur116463_1291.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0287.
HOGENOM	HOG000043494.
KO	K04517.
OMA	QRAIRWG.
ProtClustDB	PRK06545.
Enzyme and pathway databases
BioCyc	SAUR158879:GJCB-1264-MONOMER.
UniPathway	UPA00122; UER00961.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR003099. Prephen_DH. [Graphical view]
Pfam	PF02153. PDH. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_STAAN

Accession

Primary (citable) accession number: Q7A5R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program