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Q7A5R7

- TYRA_STAAN

UniProt

Q7A5R7 - TYRA_STAAN

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Protein
Prephenate dehydrogenase
Gene
tyrA, SA1197
Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3331NAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1264-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SA1197
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Prephenate dehydrogenase
PRO_0000282660Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi158879.SA1197.

Structurei

3D structure databases

ProteinModelPortaliQ7A5R7.
SMRiQ7A5R7. Positions 3-283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 291290Prephenate/arogenate dehydrogenase
Add
BLAST
Domaini296 – 36368ACT
Add
BLAST

Sequence similaritiesi

Contains 1 ACT domain.

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043494.
KOiK04517.
OMAiLQITFKN.
OrthoDBiEOG6B8XMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A5R7-1 [UniParc]FASTAAdd to Basket

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MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE    50
KCLNYSEAIK KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA 100
MIQQHESNLL KHNIHLVSGH PMAGSHKSGV LNAKKHLFEN AYYILVYNEP 150
RNEQAANTLK ELLSPTLAKF IVTTAEEHDY VTSVVSHLPH IVASSLVHVS 200
QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK TYILEMIRQL 250
KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 300
IPDESGMISK VTYIMSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER 350
GMQALSDFDC YIQ 363
Length:363
Mass (Da):40,397
Last modified:July 5, 2004 - v1
Checksum:i8867E851BCE816C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB42457.1.
PIRiE89912.
RefSeqiNP_374478.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42457; BAB42457; BAB42457.
GeneIDi1124036.
KEGGisau:SA1197.
PATRICi19574644. VBIStaAur116463_1291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB42457.1 .
PIRi E89912.
RefSeqi NP_374478.1. NC_002745.2.

3D structure databases

ProteinModelPortali Q7A5R7.
SMRi Q7A5R7. Positions 3-283.
ModBasei Search...

Protein-protein interaction databases

STRINGi 158879.SA1197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB42457 ; BAB42457 ; BAB42457 .
GeneIDi 1124036.
KEGGi sau:SA1197.
PATRICi 19574644. VBIStaAur116463_1291.

Phylogenomic databases

eggNOGi COG0287.
HOGENOMi HOG000043494.
KOi K04517.
OMAi LQITFKN.
OrthoDBi EOG6B8XMB.

Enzyme and pathway databases

UniPathwayi UPA00122 ; UER00961 .
BioCyci SAUR158879:GJCB-1264-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF02153. PDH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiTYRA_STAAN
AccessioniPrimary (citable) accession number: Q7A5R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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