UniProtKB - Q7A5M0 (NORB_STAAN)
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Protein
Quinolone resistance protein NorB
Gene
norB
Organism
Staphylococcus aureus (strain N315)
Status
Functioni
Multidrug efflux pump that acts independently of NorA and is one of the factors that confers resistance against diverse quinolones and chemical compounds.By similarity
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
- transmembrane transport Source: InterPro
Keywordsi
Biological process | Antibiotic resistance, Transport |
Protein family/group databases
TCDBi | 2.A.1.3.23. the major facilitator superfamily (mfs). |
Names & Taxonomyi
Protein namesi | Recommended name: Quinolone resistance protein NorB |
Gene namesi | Name:norB Ordered Locus Names:SA1269 |
Organismi | Staphylococcus aureus (strain N315) |
Taxonomic identifieri | 158879 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
- Cell membrane Curated; Multi-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 230 – 250 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 273 – 293 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 299 – 319 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 357 – 377 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 403 – 423 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 435 – 455 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000361963 | 1 – 463 | Quinolone resistance protein NorBAdd BLAST | 463 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | HOG000263641. |
KOi | K08170. |
OMAi | GFGMSPK. |
Family and domain databases
CDDi | cd06174. MFS. 1 hit. |
InterProi | View protein in InterPro IPR011701. MFS. IPR020846. MFS_dom. IPR036259. MFS_trans_sf. |
Pfami | View protein in Pfam PF07690. MFS_1. 1 hit. |
SUPFAMi | SSF103473. SSF103473. 2 hits. |
PROSITEi | View protein in PROSITE PS50850. MFS. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q7A5M0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKPSREAFE GNNKLLIGIV LSVITFWLFA QSLVNVVPIL EDSFNTDIGT
60 70 80 90 100
VNIAVSITAL FSGMFVVGAG GLADKYGRIK LTNIGIILNI LGSLLIIISN
110 120 130 140 150
IPLLLIIGRL IQGLSAACIM PATLSIIKSY YIGKDRQRAL SYWSIGSWGG
160 170 180 190 200
SGVCSFFGGA VATLLGWRWI FILSIIISLI ALFLIKGTPE TKSKSISLNK
210 220 230 240 250
FDIKGLVLLV IMLLTLNILI TKGSELGVTS LLFITLLAIA IGSFSLFIVL
260 270 280 290 300
EKRATNPLID FKLFKNKAYT GATASNFLLN GVAGTLIVAN TFVQRGLGYS
310 320 330 340 350
SLQAGSLSIT YLVMVLIMIR VGEKLLQTLG CKKPMLIGTG VLIVGECLIS
360 370 380 390 400
LTFLPEILYV ICCIIGYLFF GLGLGIYATP STDTAIANAP LEKVGVAAGI
410 420 430 440 450
YKMASALGGA FGVALSGAVY AIVSNMTNIY TGAMIALWLN AGMGILSFVI
460
ILLLVPKQND TQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000018 Genomic DNA. Translation: BAB42529.1. |
PIRi | D89921. |
RefSeqi | WP_000414695.1. NC_002745.2. |
Genome annotation databases
EnsemblBacteriai | BAB42529; BAB42529; BAB42529. |
KEGGi | sau:SA1269. |
Similar proteinsi
Entry informationi
Entry namei | NORB_STAAN | |
Accessioni | Q7A5M0Primary (citable) accession number: Q7A5M0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 10, 2009 |
Last sequence update: | July 5, 2004 | |
Last modified: | March 28, 2018 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |