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Q7A4C3

- Q7A4C3_STAAN

UniProt

Q7A4C3 - Q7A4C3_STAAN

Protein
Submitted name:

Repressor protein

Gene

czrA

Organism
Staphylococcus aureus (strain N315)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841ZincImported
    Metal bindingi86 – 861Zinc; via pros nitrogenImported
    Metal bindingi97 – 971Zinc; via pros nitrogenImported
    Metal bindingi100 – 1001Zinc; via tele nitrogenImported

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation, Metal-bindingImported, ZincImported

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-2080-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Repressor proteinImported
    Gene namesi
    Name:czrAImported
    OrganismiStaphylococcus aureus (strain N315)Imported
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi158879.SA1947.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GGGX-ray2.00A/B3-106[»]
    ProteinModelPortaliQ7A4C3.
    SMRiQ7A4C3. Positions 6-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HTH arsR-type DNA-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0640.
    HOGENOMiHOG000144506.
    OMAiINVESNQ.
    OrthoDBiEOG6Z3KS4.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PRINTSiPR00778. HTHARSR.
    SMARTiSM00418. HTH_ARSR. 1 hit.
    [Graphical view]
    PROSITEiPS50987. HTH_ARSR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7A4C3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN    50
    LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH 100
    PKESGL 106
    Length:106
    Mass (Da):11,989
    Last modified:July 5, 2004 - v1
    Checksum:iD3EB24D10D5EA4BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB43231.1.
    RefSeqiNP_375252.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB43231; BAB43231; BAB43231.
    GeneIDi1124848.
    KEGGisau:SA1947.
    PATRICi19576352. VBIStaAur116463_2103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB43231.1 .
    RefSeqi NP_375252.1. NC_002745.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GGG X-ray 2.00 A/B 3-106 [» ]
    ProteinModelPortali Q7A4C3.
    SMRi Q7A4C3. Positions 6-103.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA1947.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB43231 ; BAB43231 ; BAB43231 .
    GeneIDi 1124848.
    KEGGi sau:SA1947.
    PATRICi 19576352. VBIStaAur116463_2103.

    Phylogenomic databases

    eggNOGi COG0640.
    HOGENOMi HOG000144506.
    OMAi INVESNQ.
    OrthoDBi EOG6Z3KS4.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-2080-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PRINTSi PR00778. HTHARSR.
    SMARTi SM00418. HTH_ARSR. 1 hit.
    [Graphical view ]
    PROSITEi PS50987. HTH_ARSR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315Imported.
    2. "Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family."
      Campanello G.C., Ma Z., Grossoehme N.E., Guerra A.J., Ward B.P., Dimarchi R.D., Ye Y., Dann C.E., Giedroc D.P.
      J. Mol. Biol. 425:1143-1157(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 3-106 IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiQ7A4C3_STAAN
    AccessioniPrimary (citable) accession number: Q7A4C3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3