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Protein
Submitted name:

Repressor protein

Gene

czrA

Organism
Staphylococcus aureus (strain N315)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841ZincCombined sources
Metal bindingi86 – 861Zinc; via pros nitrogenCombined sources
Metal bindingi97 – 971Zinc; via pros nitrogenCombined sources
Metal bindingi100 – 1001Zinc; via tele nitrogenCombined sources

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2080-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Repressor proteinImported
Gene namesi
Name:czrAImported
OrganismiStaphylococcus aureus (strain N315)Imported
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi158879.SA1947.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GGGX-ray2.00A/B3-106[»]
ProteinModelPortaliQ7A4C3.
SMRiQ7A4C3. Positions 6-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0640.
HOGENOMiHOG000144506.
OMAiRRELCVC.
OrthoDBiEOG6Z3KS4.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A4C3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQYSEINT DTLERVTEIF KALGDYNRIR IMELLSVSEA SVGHISHQLN
60 70 80 90 100
LSQSNVSHQL KLLKSVHLVK AKRQGQSMIY SLDDIHVATM LKQAIHHANH

PKESGL
Length:106
Mass (Da):11,989
Last modified:July 5, 2004 - v1
Checksum:iD3EB24D10D5EA4BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43231.1.
RefSeqiNP_375252.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43231; BAB43231; BAB43231.
GeneIDi1124848.
KEGGisau:SA1947.
PATRICi19576352. VBIStaAur116463_2103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43231.1.
RefSeqiNP_375252.1. NC_002745.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GGGX-ray2.00A/B3-106[»]
ProteinModelPortaliQ7A4C3.
SMRiQ7A4C3. Positions 6-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158879.SA1947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB43231; BAB43231; BAB43231.
GeneIDi1124848.
KEGGisau:SA1947.
PATRICi19576352. VBIStaAur116463_2103.

Phylogenomic databases

eggNOGiCOG0640.
HOGENOMiHOG000144506.
OMAiRRELCVC.
OrthoDBiEOG6Z3KS4.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2080-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315Imported.
  2. "Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family."
    Campanello G.C., Ma Z., Grossoehme N.E., Guerra A.J., Ward B.P., Dimarchi R.D., Ye Y., Dann C.E., Giedroc D.P.
    J. Mol. Biol. 425:1143-1157(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 3-106 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ7A4C3_STAAN
AccessioniPrimary (citable) accession number: Q7A4C3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.