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Q7A382

- CLFB_STAAN

UniProt

Q7A382 - CLFB_STAAN

Protein

Clumping factor B

Gene

clfB

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei197 – 1982Cleavage; by aureolysinBy similarity
    Sitei199 – 2002Cleavage; by aureolysinBy similarity

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-2586-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Clumping factor B
    Alternative name(s):
    Fibrinogen receptor B
    Fibrinogen-binding protein B
    Gene namesi
    Name:clfB
    Ordered Locus Names:SA2423
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    Subcellular locationi

    Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4444Sequence AnalysisAdd
    BLAST
    Chaini45 – 841797Clumping factor BPRO_0000042010Add
    BLAST
    Propeptidei842 – 87736Removed by sortasePROSITE-ProRule annotationPRO_0000042011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei841 – 8411Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

    Post-translational modificationi

    Proteolytically cleaved by aureolysin (aur). This cleavage leads to the inactivation of ClfB By similarity.By similarity

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    STRINGi158879.SA2423.

    Structurei

    Secondary structure

    1
    877
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi216 – 2183
    Beta strandi219 – 2279
    Beta strandi229 – 2313
    Helixi233 – 2353
    Beta strandi239 – 2479
    Beta strandi256 – 2605
    Beta strandi265 – 2684
    Turni274 – 2785
    Beta strandi279 – 2868
    Beta strandi292 – 2998
    Turni300 – 3034
    Beta strandi304 – 3096
    Helixi311 – 3133
    Beta strandi320 – 32910
    Turni331 – 3333
    Beta strandi336 – 3416
    Beta strandi344 – 3485
    Beta strandi354 – 3574
    Beta strandi374 – 3818
    Beta strandi384 – 3874
    Beta strandi389 – 3979
    Beta strandi403 – 41513
    Helixi417 – 4193
    Turni426 – 4283
    Beta strandi430 – 4378
    Helixi439 – 4413
    Beta strandi455 – 4573
    Helixi460 – 4623
    Beta strandi465 – 4673
    Beta strandi473 – 4819
    Beta strandi485 – 4939
    Beta strandi500 – 50910
    Turni511 – 5133
    Beta strandi518 – 5269

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ASWX-ray2.60A212-531[»]
    3AT0X-ray2.50A212-541[»]
    3AU0X-ray2.45A203-541[»]
    ProteinModelPortaliQ7A382.
    SMRiQ7A382. Positions 212-528.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7A382.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni45 – 542498Ligand binding A regionBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi272 – 2765MIDAS-like motif
    Motifi838 – 8425LPXTG sorting signalPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi543 – 58442Pro-richAdd
    BLAST
    Compositional biasi581 – 803223Asp/Ser-richAdd
    BLAST

    Domaini

    The Asp/Ser-rich domain functions as a stalk to allow the ligand binding domain to be displayed in a functional form on the cell surface.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG281894.
    KOiK14192.
    OMAiEREIMST.
    OrthoDBiEOG6RNQ8T.

    Family and domain databases

    Gene3Di2.60.40.1280. 1 hit.
    2.60.40.1290. 1 hit.
    InterProiIPR011266. Adhesin_Fg-bd_dom_2.
    IPR008966. Adhesion_dom.
    IPR011252. Fibrogen-bd_dom1.
    IPR019948. Gram-positive_anchor.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PfamiPF00746. Gram_pos_anchor. 1 hit.
    PF10425. SdrG_C_C. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view]
    SUPFAMiSSF49401. SSF49401. 2 hits.
    TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7A382-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKRIDYLSN KQNKYSIRRF TVGTTSVIVG ATILFGIGNH QAQASEQSND    50
    TTQSSKNNAS ADSEKNNMIE TPQLNTTAND TSDISANTNS ANVDSTTKPM 100
    STQTSNTTTT EPASTNETPQ PTAIKNQATA AKMQDQTVPQ EANSQVDNKT 150
    TNDANSIATN SELKNSQTLD LPQSSPQTIS NAQGTSKPSV RTRAVRSLAV 200
    AEPVVNAADA KGTNVNDKVT ASNFKLEKTT FDPNQSGNTF MAANFTVTDK 250
    VKSGDYFTAK LPDSLTGNGD VDYSNSNNTM PIADIKSTNG DVVAKATYDI 300
    LTKTYTFVFT DYVNNKENIN GQFSLPLFTD RAKAPKSGTY DANINIADEM 350
    FNNKITYNYS SPIAGIDKPN GANISSQIIG VDTASGQNTY KQTVFVNPKQ 400
    RVLGNTWVYI KGYQDKIEES SGKVSATDTK LRIFEVNDTS KLSDSYYADP 450
    NDSNLKEVTD QFKNRIYYEH PNVASIKFGD ITKTYVVLVE GHYDNTGKNL 500
    KTQVIQENVD PVTNRDYSIF GWNNENVVRY GGGSADGDSA VNPKDPTPGP 550
    PVDPEPSPDP EPEPTPDPEP SPDPEPEPSP DPDPDSDSDS DSGSDSDSGS 600
    DSDSESDSDS DSDSDSDSDS DSESDSDSES DSDSDSDSDS DSDSDSESDS 650
    DSDSDSDSDS DSDSESDSDS ESDSESDSDS DSDSDSDSDS DSDSDSDSDS 700
    DSDSDSDSDS DSESDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS 750
    DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS 800
    DSDSRVTPPN NEQKAPSNPK GEVNHSNKVS KQHKTDALPE TGDKSENTNA 850
    TLFGAMMALL GSLLLFRKRK QDHKEKA 877
    Length:877
    Mass (Da):93,651
    Last modified:July 5, 2004 - v1
    Checksum:iF0EF0A57AFDB357F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB43728.1.
    PIRiF90070.
    RefSeqiNP_375749.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB43728; BAB43728; BAB43728.
    GeneIDi1125352.
    KEGGisau:SA2423.
    PATRICi19577414. VBIStaAur116463_2625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB43728.1 .
    PIRi F90070.
    RefSeqi NP_375749.1. NC_002745.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ASW X-ray 2.60 A 212-531 [» ]
    3AT0 X-ray 2.50 A 212-541 [» ]
    3AU0 X-ray 2.45 A 203-541 [» ]
    ProteinModelPortali Q7A382.
    SMRi Q7A382. Positions 212-528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA2423.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB43728 ; BAB43728 ; BAB43728 .
    GeneIDi 1125352.
    KEGGi sau:SA2423.
    PATRICi 19577414. VBIStaAur116463_2625.

    Phylogenomic databases

    eggNOGi NOG281894.
    KOi K14192.
    OMAi EREIMST.
    OrthoDBi EOG6RNQ8T.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-2586-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q7A382.
    PROi Q7A382.

    Family and domain databases

    Gene3Di 2.60.40.1280. 1 hit.
    2.60.40.1290. 1 hit.
    InterProi IPR011266. Adhesin_Fg-bd_dom_2.
    IPR008966. Adhesion_dom.
    IPR011252. Fibrogen-bd_dom1.
    IPR019948. Gram-positive_anchor.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    Pfami PF00746. Gram_pos_anchor. 1 hit.
    PF10425. SdrG_C_C. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49401. SSF49401. 2 hits.
    TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.

    Entry informationi

    Entry nameiCLFB_STAAN
    AccessioniPrimary (citable) accession number: Q7A382
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3