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Q7A382

- CLFB_STAAN

UniProt

Q7A382 - CLFB_STAAN

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Protein

Clumping factor B

Gene

clfB

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei197 – 1982Cleavage; by aureolysinBy similarity
Sitei199 – 2002Cleavage; by aureolysinBy similarity

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-2586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Clumping factor B
Alternative name(s):
Fibrinogen receptor B
Fibrinogen-binding protein B
Gene namesi
Name:clfB
Ordered Locus Names:SA2423
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

Subcellular locationi

Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Sequence AnalysisAdd
BLAST
Chaini45 – 841797Clumping factor BPRO_0000042010Add
BLAST
Propeptidei842 – 87736Removed by sortasePROSITE-ProRule annotationPRO_0000042011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei841 – 8411Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Post-translational modificationi

Proteolytically cleaved by aureolysin (aur). This cleavage leads to the inactivation of ClfB By similarity.By similarity

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

STRINGi158879.SA2423.

Structurei

Secondary structure

1
877
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi216 – 2183
Beta strandi219 – 2279
Beta strandi229 – 2313
Helixi233 – 2353
Beta strandi239 – 2479
Beta strandi256 – 2605
Beta strandi265 – 2684
Turni274 – 2785
Beta strandi279 – 2868
Beta strandi292 – 2998
Turni300 – 3034
Beta strandi304 – 3096
Helixi311 – 3133
Beta strandi320 – 32910
Turni331 – 3333
Beta strandi336 – 3416
Beta strandi344 – 3485
Beta strandi354 – 3574
Beta strandi374 – 3818
Beta strandi384 – 3874
Beta strandi389 – 3979
Beta strandi403 – 41513
Helixi417 – 4193
Turni426 – 4283
Beta strandi430 – 4378
Helixi439 – 4413
Beta strandi455 – 4573
Helixi460 – 4623
Beta strandi465 – 4673
Beta strandi473 – 4819
Beta strandi485 – 4939
Beta strandi500 – 50910
Turni511 – 5133
Beta strandi518 – 5269

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ASWX-ray2.60A212-531[»]
3AT0X-ray2.50A212-541[»]
3AU0X-ray2.45A203-541[»]
ProteinModelPortaliQ7A382.
SMRiQ7A382. Positions 212-528.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7A382.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni45 – 542498Ligand binding A regionBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi272 – 2765MIDAS-like motif
Motifi838 – 8425LPXTG sorting signalPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi543 – 58442Pro-richAdd
BLAST
Compositional biasi581 – 803223Asp/Ser-richAdd
BLAST

Domaini

The Asp/Ser-rich domain functions as a stalk to allow the ligand binding domain to be displayed in a functional form on the cell surface.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG281894.
KOiK14192.
OMAiEREIMST.
OrthoDBiEOG6RNQ8T.

Family and domain databases

Gene3Di2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProiIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7A382-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKRIDYLSN KQNKYSIRRF TVGTTSVIVG ATILFGIGNH QAQASEQSND
60 70 80 90 100
TTQSSKNNAS ADSEKNNMIE TPQLNTTAND TSDISANTNS ANVDSTTKPM
110 120 130 140 150
STQTSNTTTT EPASTNETPQ PTAIKNQATA AKMQDQTVPQ EANSQVDNKT
160 170 180 190 200
TNDANSIATN SELKNSQTLD LPQSSPQTIS NAQGTSKPSV RTRAVRSLAV
210 220 230 240 250
AEPVVNAADA KGTNVNDKVT ASNFKLEKTT FDPNQSGNTF MAANFTVTDK
260 270 280 290 300
VKSGDYFTAK LPDSLTGNGD VDYSNSNNTM PIADIKSTNG DVVAKATYDI
310 320 330 340 350
LTKTYTFVFT DYVNNKENIN GQFSLPLFTD RAKAPKSGTY DANINIADEM
360 370 380 390 400
FNNKITYNYS SPIAGIDKPN GANISSQIIG VDTASGQNTY KQTVFVNPKQ
410 420 430 440 450
RVLGNTWVYI KGYQDKIEES SGKVSATDTK LRIFEVNDTS KLSDSYYADP
460 470 480 490 500
NDSNLKEVTD QFKNRIYYEH PNVASIKFGD ITKTYVVLVE GHYDNTGKNL
510 520 530 540 550
KTQVIQENVD PVTNRDYSIF GWNNENVVRY GGGSADGDSA VNPKDPTPGP
560 570 580 590 600
PVDPEPSPDP EPEPTPDPEP SPDPEPEPSP DPDPDSDSDS DSGSDSDSGS
610 620 630 640 650
DSDSESDSDS DSDSDSDSDS DSESDSDSES DSDSDSDSDS DSDSDSESDS
660 670 680 690 700
DSDSDSDSDS DSDSESDSDS ESDSESDSDS DSDSDSDSDS DSDSDSDSDS
710 720 730 740 750
DSDSDSDSDS DSESDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS
760 770 780 790 800
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS
810 820 830 840 850
DSDSRVTPPN NEQKAPSNPK GEVNHSNKVS KQHKTDALPE TGDKSENTNA
860 870
TLFGAMMALL GSLLLFRKRK QDHKEKA
Length:877
Mass (Da):93,651
Last modified:July 5, 2004 - v1
Checksum:iF0EF0A57AFDB357F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43728.1.
PIRiF90070.
RefSeqiNP_375749.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43728; BAB43728; BAB43728.
GeneIDi1125352.
KEGGisau:SA2423.
PATRICi19577414. VBIStaAur116463_2625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000018 Genomic DNA. Translation: BAB43728.1 .
PIRi F90070.
RefSeqi NP_375749.1. NC_002745.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ASW X-ray 2.60 A 212-531 [» ]
3AT0 X-ray 2.50 A 212-541 [» ]
3AU0 X-ray 2.45 A 203-541 [» ]
ProteinModelPortali Q7A382.
SMRi Q7A382. Positions 212-528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA2423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB43728 ; BAB43728 ; BAB43728 .
GeneIDi 1125352.
KEGGi sau:SA2423.
PATRICi 19577414. VBIStaAur116463_2625.

Phylogenomic databases

eggNOGi NOG281894.
KOi K14192.
OMAi EREIMST.
OrthoDBi EOG6RNQ8T.

Enzyme and pathway databases

BioCyci SAUR158879:GJCB-2586-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q7A382.
PROi Q7A382.

Family and domain databases

Gene3Di 2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProi IPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view ]
SUPFAMi SSF49401. SSF49401. 2 hits.
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiCLFB_STAAN
AccessioniPrimary (citable) accession number: Q7A382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3