Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q7A382 (CLFB_STAAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Clumping factor B
Alternative name(s):
Fibrinogen receptor B
Fibrinogen-binding protein B
Gene names
Name:clfB
Ordered Locus Names:SA2423
OrganismStaphylococcus aureus (strain N315) [Complete proteome] [HAMAP]
Taxonomic identifier158879 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length877 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps By similarity.

Subcellular location

Secreted › cell wall; Peptidoglycan-anchor Potential.

Domain

The Asp/Ser-rich domain functions as a stalk to allow the ligand binding domain to be displayed in a functional form on the cell surface By similarity.

Post-translational modification

Proteolytically cleaved by aureolysin (aur). This cleavage leads to the inactivation of ClfB By similarity.

Sequence similarities

Belongs to the serine-aspartate repeat-containing protein (SDr) family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell wall
Secreted
   DomainSignal
   PTMPeptidoglycan-anchor
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4444 Potential
Chain45 – 841797Clumping factor B
PRO_0000042010
Propeptide842 – 87736Removed by sortase Potential
PRO_0000042011

Regions

Region45 – 542498Ligand binding A region By similarity
Motif272 – 2765MIDAS-like motif
Motif838 – 8425LPXTG sorting signal Potential
Compositional bias543 – 58442Pro-rich
Compositional bias581 – 803223Asp/Ser-rich

Sites

Site197 – 1982Cleavage; by aureolysin By similarity
Site199 – 2002Cleavage; by aureolysin By similarity

Amino acid modifications

Modified residue8411Pentaglycyl murein peptidoglycan amidated threonine Potential

Secondary structure

1 ................................................................. 877
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7A382 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F0EF0A57AFDB357F

FASTA87793,651
        10         20         30         40         50         60 
MKKRIDYLSN KQNKYSIRRF TVGTTSVIVG ATILFGIGNH QAQASEQSND TTQSSKNNAS 

        70         80         90        100        110        120 
ADSEKNNMIE TPQLNTTAND TSDISANTNS ANVDSTTKPM STQTSNTTTT EPASTNETPQ 

       130        140        150        160        170        180 
PTAIKNQATA AKMQDQTVPQ EANSQVDNKT TNDANSIATN SELKNSQTLD LPQSSPQTIS 

       190        200        210        220        230        240 
NAQGTSKPSV RTRAVRSLAV AEPVVNAADA KGTNVNDKVT ASNFKLEKTT FDPNQSGNTF 

       250        260        270        280        290        300 
MAANFTVTDK VKSGDYFTAK LPDSLTGNGD VDYSNSNNTM PIADIKSTNG DVVAKATYDI 

       310        320        330        340        350        360 
LTKTYTFVFT DYVNNKENIN GQFSLPLFTD RAKAPKSGTY DANINIADEM FNNKITYNYS 

       370        380        390        400        410        420 
SPIAGIDKPN GANISSQIIG VDTASGQNTY KQTVFVNPKQ RVLGNTWVYI KGYQDKIEES 

       430        440        450        460        470        480 
SGKVSATDTK LRIFEVNDTS KLSDSYYADP NDSNLKEVTD QFKNRIYYEH PNVASIKFGD 

       490        500        510        520        530        540 
ITKTYVVLVE GHYDNTGKNL KTQVIQENVD PVTNRDYSIF GWNNENVVRY GGGSADGDSA 

       550        560        570        580        590        600 
VNPKDPTPGP PVDPEPSPDP EPEPTPDPEP SPDPEPEPSP DPDPDSDSDS DSGSDSDSGS 

       610        620        630        640        650        660 
DSDSESDSDS DSDSDSDSDS DSESDSDSES DSDSDSDSDS DSDSDSESDS DSDSDSDSDS 

       670        680        690        700        710        720 
DSDSESDSDS ESDSESDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSESDSDSDS 

       730        740        750        760        770        780 
DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS 

       790        800        810        820        830        840 
DSDSDSDSDS DSDSDSDSDS DSDSRVTPPN NEQKAPSNPK GEVNHSNKVS KQHKTDALPE 

       850        860        870 
TGDKSENTNA TLFGAMMALL GSLLLFRKRK QDHKEKA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000018 Genomic DNA. Translation: BAB43728.1.
PIRF90070.
RefSeqNP_375749.1. NC_002745.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ASWX-ray2.60A212-531[»]
3AT0X-ray2.50A212-541[»]
3AU0X-ray2.45A203-541[»]
ProteinModelPortalQ7A382.
SMRQ7A382. Positions 212-528.
ModBaseSearch...

Protein-protein interaction databases

STRING158879.SA2423.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB43728; BAB43728; BAB43728.
GeneID1125352.
KEGGsau:SA2423.
PATRIC19577414. VBIStaAur116463_2625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG281894.
KOK14192.
OMAVASINFG.
ProtClustDBCLSK886119.

Enzyme and pathway databases

BioCycSAUR158879:GJCB-2586-MONOMER.

Family and domain databases

Gene3D2.60.40.1280. 1 hit.
2.60.40.1290. 1 hit.
InterProIPR011266. Adhesin_Fg-bd_dom_2.
IPR008966. Adhesion_dom.
IPR011252. Fibrogen-bd_dom1.
IPR005877. Gpos_YSIRK.
IPR019948. Gram-positive_anchor.
IPR019931. LPXTG-motif_cell_wall_anchor.
[Graphical view]
PfamPF00746. Gram_pos_anchor. 1 hit.
PF10425. SdrG_C_C. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SUPFAMSSF49401. Adhes_bact. 2 hits.
TIGRFAMsTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ7A382.

Entry information

Entry nameCLFB_STAAN
AccessionPrimary (citable) accession number: Q7A382
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents