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Protein

Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase

Gene

icaB

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase (EC:3.5.1.-)
Short name:
PNAG N-deacetylase
Short name:
Poly-beta-1,6-GlcNAc N-deacetylase
Alternative name(s):
Biofilm polysaccharide intercellular adhesin deacetylase
Short name:
Biofilm PIA deacetylase
Intercellular adhesion protein B
Gene namesi
Name:icaB
Ordered Locus Names:SA2461
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

  • cell wall
  • Note: Attached to the cell surface.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002483629 – 290Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylaseAdd BLAST262

Structurei

3D structure databases

ProteinModelPortaliQ7A349.
SMRiQ7A349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 290NodB homologyPROSITE-ProRule annotationAdd BLAST177

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000280325.
KOiK21478.
OMAiHTNDLHY.

Family and domain databases

InterProiView protein in InterPro
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
IPR023872. PNAG_deacetylase.
PfamiView protein in Pfam
PF01522. Polysacc_deac_1. 1 hit.
SUPFAMiSSF88713. SSF88713. 1 hit.
TIGRFAMsiTIGR03933. PIA_icaB. 1 hit.
PROSITEiView protein in PROSITE
PS51677. NODB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7A349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYRKLIILV LSILIILPVS TLDGHHIANA DDDSPKKLKY KENSALALNY
60 70 80 90 100
HRVRKANFLN NFIYFFSSSK EIKNYSVSQS QFESQIKWLK SHDAKFLTLK
110 120 130 140 150
EFLYYKKKGK FPKRSVWINF DDMDETIYEN AYPILKKYKI PATGFIITGH
160 170 180 190 200
VGEENFHNLD MISKKELKEM YKTGLWEFET HTHDLHNLSK NNKSKLMKAS
210 220 230 240 250
EATIIKDLNK SEKYLTKNFK KSQKTIAYPY GLMNDDKLPV IKKAGLKYGF
260 270 280 290
SLEEKAVTPN SNDYYIPRIL ISDDAFEHLI KRWDGFHEKD
Length:290
Mass (Da):34,071
Last modified:July 5, 2004 - v1
Checksum:i70F7F2B8454F2E2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB43766.1.
PIRiD90075.
RefSeqiWP_000877369.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB43766; BAB43766; BAB43766.
KEGGisau:SA2461.

Similar proteinsi

Entry informationi

Entry nameiICAB_STAAN
AccessioniPrimary (citable) accession number: Q7A349
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families