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Protein

Signal transduction histidine-protein kinase ArlS

Gene

arlS

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system, Virulence
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction histidine-protein kinase ArlS (EC:2.7.13.3)
Gene namesi
Name:arlS
Ordered Locus Names:SAV1414
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000746901 – 451Signal transduction histidine-protein kinase ArlSAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7A2R7.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1414.

Structurei

3D structure databases

ProteinModelPortaliQ7A2R7.
SMRiQ7A2R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 231HAMPPROSITE-ProRule annotationAdd BLAST54
Domaini239 – 451Histidine kinasePROSITE-ProRule annotationAdd BLAST213

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105GR3. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000223177.
KOiK18940.
OMAiMTIMIND.
PhylomeDBiQ7A2R7.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7A2R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKRKLRNNW IIVTTMITFV TIFLFCLIII FFLKDTLHNS ELDDAERSSS
60 70 80 90 100
DINNLFHSKP VKDISALDLN ASLGNFQEII IYDEHNNKLF ETSNDNTVRV
110 120 130 140 150
EPGYEHRYFD RVIKKRYKGI EYLIIKEPIT TQDFKGYSLL IHSLENYDNI
160 170 180 190 200
VKSLYIIALA FGVIATIITA TISYVFSTQI TKPLVSLSNK MIEIRRDGFQ
210 220 230 240 250
NKLQLNTNYE EIDNLANTFN EMMSQIEESF NQQRQFVEDA SHELRTPLQI
260 270 280 290 300
IQGHLNLIQR WGKKDPAVLE ESLNISIEEM NRIIKLVEEL LELTKGDVND
310 320 330 340 350
ISSEAQTVHI NDEIRSRIHS LKQLHPDYQF DTDLTSKNLE IKMKPHQFEQ
360 370 380 390 400
LFLIFIDNAI KYDVKNKKIK VKTRLKNKQK IIEITDHGIG IPEEDQDFIF
410 420 430 440 450
DRFYRVDKSR SRSQGGNGLG LSIAQKIIQL NGGSIKIKSE INKGTTFKII

F
Length:451
Mass (Da):52,400
Last modified:July 5, 2004 - v1
Checksum:i6308576067A22438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57576.1.
RefSeqiWP_000166801.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57576; BAB57576; SAV1414.
KEGGisav:SAV1414.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiARLS_STAAM
AccessioniPrimary (citable) accession number: Q7A2R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome