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Protein

Response regulator protein VraR

Gene

vraR

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu50, which leads to vancomycin resistance.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi165 – 184H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Antibiotic resistance, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Response regulator protein VraR
Gene namesi
Name:vraR
Ordered Locus Names:SAV1884
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000812701 – 209Response regulator protein VraRAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by VraS.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7A2Q1.
PRIDEiQ7A2Q1.

2D gel databases

World-2DPAGE0002:Q7A2Q1.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1884.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi12 – 24Combined sources13
Beta strandi28 – 36Combined sources9
Helixi37 – 47Combined sources11
Beta strandi50 – 57Combined sources8
Beta strandi59 – 62Combined sources4
Helixi63 – 71Combined sources9
Beta strandi77 – 84Combined sources8
Helixi88 – 96Combined sources9
Beta strandi101 – 104Combined sources4
Helixi109 – 120Combined sources12
Helixi128 – 130Combined sources3
Helixi131 – 143Combined sources13
Helixi144 – 147Combined sources4
Helixi150 – 160Combined sources11
Helixi165 – 172Combined sources8
Helixi176 – 189Combined sources14
Helixi195 – 204Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RNJNMR-A138-209[»]
4GVPX-ray2.03A/B/C/D2-209[»]
4IF4X-ray2.35A/B/C/D2-209[»]
ProteinModelPortaliQ7A2Q1.
SMRiQ7A2Q1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7A2Q1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST117
Domaini141 – 206HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
KOiK07694.
OMAiIRATFHG.
PhylomeDBiQ7A2Q1.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A2Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKVLFVDD HEMVRIGISS YLSTQSDIEV VGEGASGKEA IAKAHELKPD
60 70 80 90 100
LILMDLLMED MDGVEATTQI KKDLPQIKVL MLTSFIEDKE VYRALDAGVD
110 120 130 140 150
SYILKTTSAK DIADAVRKTS RGESVFEPEV LVKMRNRMKK RAELYEMLTE
160 170 180 190 200
REMEILLLIA KGYSNQEIAS ASHITIKTVK THVSNILSKL EVQDRTQAVI

YAFQHNLIQ
Length:209
Mass (Da):23,559
Last modified:July 5, 2004 - v1
Checksum:i52984CE9494925B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58046.1.
RefSeqiWP_000153535.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58046; BAB58046; SAV1884.
KEGGisav:SAV1884.
PATRICi19564614. VBIStaAur52173_1946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58046.1.
RefSeqiWP_000153535.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RNJNMR-A138-209[»]
4GVPX-ray2.03A/B/C/D2-209[»]
4IF4X-ray2.35A/B/C/D2-209[»]
ProteinModelPortaliQ7A2Q1.
SMRiQ7A2Q1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1884.

2D gel databases

World-2DPAGE0002:Q7A2Q1.

Proteomic databases

PaxDbiQ7A2Q1.
PRIDEiQ7A2Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58046; BAB58046; SAV1884.
KEGGisav:SAV1884.
PATRICi19564614. VBIStaAur52173_1946.

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
KOiK07694.
OMAiIRATFHG.
PhylomeDBiQ7A2Q1.

Miscellaneous databases

EvolutionaryTraceiQ7A2Q1.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVRAR_STAAM
AccessioniPrimary (citable) accession number: Q7A2Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.