Reviewed,
UniProtKB/Swiss-Prot Q7A1Y8 (ISDI_STAAW)
Last modified
June 16, 2009.
Version 33.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Heme-degrading monooxygenase isdG EC=1.14.99.3 Alternative name(s): Iron-regulated surface determinant isdG Iron-responsive surface determinant isdG Heme oxygenase | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain MW2) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 196620 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 108 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron By similarity. |
| Catalytic activity | Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O. HAMAP MF_01272 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase isdG subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | antibiotic biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | heme binding Inferred from electronic annotation. Source: HAMAP heme oxygenase (decyclizing) activityInferred from electronic annotation. Source: EC monooxygenase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 108 | 108 | Heme-degrading monooxygenase isdG HAMAP MF_01272 | PRO_0000270090 | |||||
Sites | |||||||||
| Metal binding | 6 | 1 | Iron Potential | ||||||
| Metal binding | 76 | 1 | Iron (heme axial ligand) Potential | ||||||
| Site | 66 | 1 | Transition state stabilizer Potential | ||||||
Sequences
References
| [1] | "Genome and virulence determinants of high virulence community-acquired MRSA." Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K. Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| BA000033 Genomic DNA. Translation: BAB94005.1. | |
| RefSeq | NP_644955.1. |
3D structure databases | |
| SMR | Q7A1Y8. Positions 1-108. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1004894. |
| GenomeReviews | Gene locus MW0140 in contig BA000033_GR. |
| KEGG | sam:MW0140. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q7A1Y8. |
| OMA | Q7A1Y8. DAHSHQG. |
Enzyme and pathway databases | |
| BioCyc | SAUR196620:MW0140-MON. |
Family and domain databases | |
| HAMAP | MF_01272. [Tree] |
| InterPro | IPR007138. Antibiotic_mOase. [Graphical view] |
| Pfam | PF03992. ABM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ISDI_STAAW | ||||||||
| Accession | Primary (citable) accession number: Q7A1Y8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


