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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:MW0419
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023162626 – 334N-acetylmuramoyl-L-alanine amidase sle1Add BLAST309

Structurei

3D structure databases

ProteinModelPortaliQ7A1T4.
SMRiQ7A1T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 70LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini91 – 134LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini158 – 201LysM 3PROSITE-ProRule annotationAdd BLAST44
Domaini210 – 334Peptidase C51PROSITE-ProRule annotationAdd BLAST125

Sequence similaritiesi

Contains 3 LysM domains.PROSITE-ProRule annotation
Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000279823.
OMAiNTPVFNH.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
PS51782. LYSM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7A1T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK
60 70 80 90 100
LKSLNNLTSN LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS
110 120 130 140 150
LSLIASKYGT TYQNIMRLNG LNNFFIYPGQ KLKVSGTASS SNAASNSSRP
160 170 180 190 200
STNSGGGSYY TVQAGDSLSL IASKYGTTYQ KIMSLNGLNN FFIYPGQKLK
210 220 230 240 250
VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF NRRAEIGKGI
260 270 280 290 300
STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND
310 320 330
GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH
Length:334
Mass (Da):35,836
Last modified:July 5, 2004 - v1
Checksum:i4C1E30AD9DE61D36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94284.1.
RefSeqiWP_001170264.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94284; BAB94284; BAB94284.
GeneIDi28379223.
KEGGisam:MW0419.
PATRICi19567330. VBIStaAur44266_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94284.1.
RefSeqiWP_001170264.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ7A1T4.
SMRiQ7A1T4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB94284; BAB94284; BAB94284.
GeneIDi28379223.
KEGGisam:MW0419.
PATRICi19567330. VBIStaAur44266_0447.

Phylogenomic databases

HOGENOMiHOG000279823.
OMAiNTPVFNH.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
PS51782. LYSM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLE1_STAAW
AccessioniPrimary (citable) accession number: Q7A1T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.