Q7A124 (FABD_STAAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malonyl CoA-acyl carrier protein transacylase
Short name=MCT
EC=2.3.1.39

Gene names

Name:	fabD
Ordered Locus Names:	MW1113

Organism

Staphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]

Taxonomic identifier

196620 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the fabD family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Malonyl CoA-acyl carrier protein transacylase		PRO_0000194225
Sites
	Active site	89	1	By similarity
	Active site	199	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7A124 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B2FAEF8A200804C3	FASTA	308	33,649
	10 20 30 40 50 60 MSKTAIIFPG QGAQKVGMAQ DLFNNNDQAT EILTSAAKTL DFDILETMFT DEEGKLGETE 70 80 90 100 110 120 NTQPALLTHS SALLAALKNL NPDFTMGHSL GEYSSLVAAD VLSFEDAVKI VRKRGQLMAQ 130 140 150 160 170 180 AFPTGVGSMA AVLGLDFDKV DEICKSLSSD DKIIEPANIN CPGQIVVSGH KALIDELVEK 190 200 210 220 230 240 GKSLGAKRVM PLAVSGPFHS SLMKVIEEDF SSYINQFEWR DAKFPVVQNV NAQGETDKEV 250 260 270 280 290 300 IKSNMVKQLY SPVQFINSTE WLIDQGVDHF IEIGPGKVLS GLIKKINRDV KLTSIQTLED VKGWNEND

References

[1]	"Genome and virulence determinants of high virulence community-acquired MRSA." Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K. Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MW2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000033 Genomic DNA. Translation: BAB94978.1.
RefSeq	NP_645930.1. NC_003923.1.
3D structure databases
ProteinModelPortal	Q7A124.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7A124.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000027525; EBSTAP00000026564; EBSTAG00000027524.
GeneID	1003225.
GenomeReviews	Gene locus MW1113 in contig BA000033_GR.
KEGG	sam:MW1113.
PATRIC	19568816. VBIStaAur44266_1168.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0331.
GeneTree	EBGT00050000023910.
HOGENOM	HBG687898.
OMA	NAMQAAV.
PhylomeDB	Q7A124.
ProtClustDB	CLSK885219.
Enzyme and pathway databases
BioCyc	SAUR196620:MW1113-MONOMER.
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR024925. Malonyl_CoA-ACP_transAc. IPR004410. Malonyl_CoA-ACP_transAc_FabD. IPR016036. Malonyl_transacylase_ACP-bd. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits.
KO	K00645.
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000446. Mct. 1 hit.
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.
TIGRFAMs	TIGR00128. FabD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABD_STAAW

Accession

Primary (citable) accession number: Q7A124

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program