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Protein

Putative multidrug export ATP-binding/permease protein MW1806

Gene

MW1806

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi374 – 381ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1868-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multidrug export ATP-binding/permease protein MW1806 (EC:3.6.3.-)
Gene namesi
Ordered Locus Names:MW1806
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini37 – 59ExtracellularSequence analysisAdd BLAST23
Transmembranei60 – 80HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini81 – 138CytoplasmicSequence analysisAdd BLAST58
Transmembranei139 – 159HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini160 – 162ExtracellularSequence analysis3
Transmembranei163 – 183HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini184 – 244CytoplasmicSequence analysisAdd BLAST61
Transmembranei245 – 263HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini264 – 269ExtracellularSequence analysis6
Transmembranei270 – 287HelicalPROSITE-ProRule annotationAdd BLAST18
Topological domaini288 – 578CytoplasmicSequence analysisAdd BLAST291

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002715531 – 578Putative multidrug export ATP-binding/permease protein MW1806Add BLAST578

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7A0J1.
SMRiQ7A0J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 306ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini340 – 575ABC transporterPROSITE-ProRule annotationAdd BLAST236

Domaini

The ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiHERVQGM.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7A0J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKRYLQFVK PYKYRIFATI IVGIIKFGIP MLIPLLIKYA IDGVINNHAL
60 70 80 90 100
TTDEKVHHLT IAIGIALFIF VIVRPPIEFI RQYLAQWTSN KILYDIRKKL
110 120 130 140 150
YNHLQALSAR FYANNQVGQV ISRVINDVEQ TKDFILTGLM NIWLDCITII
160 170 180 190 200
IALSIMFFLD VKLTLAALFI FPFYILTVYV FFGRLRKLTR ERSQALAEVQ
210 220 230 240 250
GFLHERVQGI SVVKSFAIED NEAKNFDKKN TNFLTRALKH TRWNAYSFAA
260 270 280 290 300
INTVTDIGPI IVIGVGAYLA ISGSITVGTL AAFVGYLELL FGPLRRLVAS
310 320 330 340 350
FTTLTQSFAS MDRVFQLIDE DYDIKNGVGA QPIEIKQGRI DIDHVSFQYN
360 370 380 390 400
DNEAPILKDI NLSIEKGETV AFVGMSGGGK STLINLIPRF YDVTSGQILI
410 420 430 440 450
DGHNIKDFLT GSLRNQIGLV QQDNILFSDT VKENILLGRP TATDEEVVEA
460 470 480 490 500
AKMANAHDFI MNLPQGYDTE VGERGVKLSG GQKQRLSIAR IFLNNPPILI
510 520 530 540 550
LDEATSALDL ESESIIQEAL DVLSKDRTTL IVAHRLSTIT HADKIVVIEN
560 570
GHIVETGTHR ELIAKQGAYE HLYSIQNL
Length:578
Mass (Da):64,863
Last modified:July 5, 2004 - v1
Checksum:i0DA5945AE8F1799C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95671.1.
RefSeqiWP_000597238.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95671; BAB95671; BAB95671.
KEGGisam:MW1806.

Similar proteinsi

Entry informationi

Entry nameiY1806_STAAW
AccessioniPrimary (citable) accession number: Q7A0J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families