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Q7A0B9 (PTPB_STAAW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight protein-tyrosine-phosphatase PtpB

EC=3.1.3.48
Alternative name(s):
Phosphotyrosine phosphatase B
Short name=PTPase B
Gene names
Name:ptpB
Ordered Locus Names:MW2039
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dephosphorylates the phosphotyrosine-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 139139Low molecular weight protein-tyrosine-phosphatase PtpB
PRO_0000300676

Sites

Active site71Nucleophile By similarity
Active site131 By similarity
Active site1111Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7A0B9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 63EB2C0E2A53EA5B

FASTA13915,788
        10         20         30         40         50         60 
MKILFVCTGN TCRSPLAESI AKEVMPNHQF ESRGIFAVNN QGVSNYVEDL VEEHHLAETT 

        70         80         90        100        110        120 
LSQQFTEADL KADIILTMSY SHKELIEAHF GLQNHVFTLH EYVKEAGEVI DPYGGTKEMY 

       130 
VHTYEELVSL ILKLKDIIC 

« Hide

References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MW2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000033 Genomic DNA. Translation: BAB95904.1.
RefSeqNP_646856.1. NC_003923.1.

3D structure databases

ProteinModelPortalQ7A0B9.
SMRQ7A0B9. Positions 1-134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196620.MW2039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB95904; BAB95904; BAB95904.
GeneID1004155.
KEGGsam:MW2039.
PATRIC19570792. VBIStaAur44266_2114.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273091.
KOK01104.
OMAPMAMALL.
OrthoDBEOG6MH5JB.
ProtClustDBCLSK885771.

Enzyme and pathway databases

BioCycSAUR196620:GJ9Z-2108-MONOMER.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
[Graphical view]
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTPB_STAAW
AccessionPrimary (citable) accession number: Q7A0B9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families