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Q7A057

- FDHL_STAAW

UniProt

Q7A057 - FDHL_STAAW

Protein

Putative formate dehydrogenase MW2229

Gene

MW2229

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 4 4Fe-4S clusters.By similarity
    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity
    Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. electron carrier activity Source: InterPro
    4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    5. molybdenum ion binding Source: InterPro

    GO - Biological processi

    1. formate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

    Enzyme and pathway databases

    BioCyciSAUR196620:GJ9Z-2306-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative formate dehydrogenase MW2229 (EC:1.2.1.2)
    Gene namesi
    Ordered Locus Names:MW2229
    OrganismiStaphylococcus aureus (strain MW2)
    Taxonomic identifieri196620 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000418: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 984984Putative formate dehydrogenase MW2229PRO_0000304133Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196620.MW2229.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7A057.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 79772Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 165284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 211314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini257 – 313574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni252 – 984733Formate dehydrogenaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG3383.
    HOGENOMiHOG000031440.
    KOiK00123.
    OMAiVAATWIK.
    OrthoDBiEOG6CVV7G.

    Family and domain databases

    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view]
    PfamiPF12838. Fer4_7. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036643. FDH_alpha. 1 hit.
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7A057-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT    50
    CTVEIDGKIE RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT 100
    VCDYNNGDCE IHNTMDAWGL QHQTYEYKEK PYEKDYGPFY RYDPNQCILC 150
    GRCVEACQDI EVNETIRIDW DREHPRVIWD NDVPINESSC VSCGQCATVC 200
    PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGYG PLFAISDSEA 250
    EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 300
    KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTSIKEKYG 350
    PDALSFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR 400
    TVGHGGDSGS IEDLEKAAMS VLIGTNTAEA HPVIASRMKR AQKLFGQKIH 450
    VFDIRKHEMA ERADRFYQPK PGTDLAWLSA VTKYIIDHDL HDKAFIDEWV 500
    DDFDEYYKSL ETFTMAFAEE ATGIPESELI KFAEECAKAE SVVICWAMGI 550
    TQQDIGSDSS TAISNLLLVT GNYRRPGTGA YPLRGHNNVQ GCSDMGSMPD 600
    KITGYQSIEA DDIRAKFEKE YGVKLNPKAG KDNHEMVEGI HDGEVHSLYL 650
    YGEDTGIVDS NINFVQAAFE KLDFMVVQDE FLTFTATYAD VVLPASPSLE 700
    KDGTFTNTER RIQRLYQALE PLGDSKPDWK IFQAIANRLG FDWNYKHPSE 750
    IMDEVARLTP LYAGVSYDRL EGFNSLQWPV QPDGTDEPIL YLEGFNFDNG 800
    KAKLFPLSFD NYFKQDEIYD IHVNNGRLLE HFHEGNMTYQ TPMIKYKVPR 850
    AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 900
    NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIT KRGKSPLNPN 950
    NFRVNKKRHP QYSVQVQKKW ERSDYVFPGN QVDK 984
    Length:984
    Mass (Da):111,295
    Last modified:July 5, 2004 - v1
    Checksum:i79140674B6A0C1D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB96094.1.
    RefSeqiNP_647046.1. NC_003923.1.

    Genome annotation databases

    EnsemblBacteriaiBAB96094; BAB96094; BAB96094.
    GeneIDi1004347.
    KEGGisam:MW2229.
    PATRICi19571186. VBIStaAur44266_2303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB96094.1 .
    RefSeqi NP_647046.1. NC_003923.1.

    3D structure databases

    ProteinModelPortali Q7A057.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196620.MW2229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB96094 ; BAB96094 ; BAB96094 .
    GeneIDi 1004347.
    KEGGi sam:MW2229.
    PATRICi 19571186. VBIStaAur44266_2303.

    Phylogenomic databases

    eggNOGi COG3383.
    HOGENOMi HOG000031440.
    KOi K00123.
    OMAi VAATWIK.
    OrthoDBi EOG6CVV7G.

    Enzyme and pathway databases

    BioCyci SAUR196620:GJ9Z-2306-MONOMER.

    Family and domain databases

    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view ]
    Pfami PF12838. Fer4_7. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036643. FDH_alpha. 1 hit.
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MW2.

    Entry informationi

    Entry nameiFDHL_STAAW
    AccessioniPrimary (citable) accession number: Q7A057
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3