SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7A057

- FDHL_STAAW

UniProt

Q7A057 - FDHL_STAAW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Putative formate dehydrogenase MW2229
Gene
MW2229
Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 4 4Fe-4S clusters By similarity.
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase MW2229 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:MW2229
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Putative formate dehydrogenase MW2229
PRO_0000304133Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196620.MW2229.

Structurei

3D structure databases

ProteinModelPortaliQ7A057.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 79772Fe-2S ferredoxin-type
Add
BLAST
Domaini138 – 165284Fe-4S ferredoxin-type 1
Add
BLAST
Domaini181 – 211314Fe-4S ferredoxin-type 2
Add
BLAST
Domaini257 – 313574Fe-4S Mo/W bis-MGD-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 984733Formate dehydrogenase
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiVAATWIK.
OrthoDBiEOG6CVV7G.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A057-1 [UniParc]FASTAAdd to Basket

« Hide

MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT    50
CTVEIDGKIE RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT 100
VCDYNNGDCE IHNTMDAWGL QHQTYEYKEK PYEKDYGPFY RYDPNQCILC 150
GRCVEACQDI EVNETIRIDW DREHPRVIWD NDVPINESSC VSCGQCATVC 200
PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGYG PLFAISDSEA 250
EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 300
KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTSIKEKYG 350
PDALSFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR 400
TVGHGGDSGS IEDLEKAAMS VLIGTNTAEA HPVIASRMKR AQKLFGQKIH 450
VFDIRKHEMA ERADRFYQPK PGTDLAWLSA VTKYIIDHDL HDKAFIDEWV 500
DDFDEYYKSL ETFTMAFAEE ATGIPESELI KFAEECAKAE SVVICWAMGI 550
TQQDIGSDSS TAISNLLLVT GNYRRPGTGA YPLRGHNNVQ GCSDMGSMPD 600
KITGYQSIEA DDIRAKFEKE YGVKLNPKAG KDNHEMVEGI HDGEVHSLYL 650
YGEDTGIVDS NINFVQAAFE KLDFMVVQDE FLTFTATYAD VVLPASPSLE 700
KDGTFTNTER RIQRLYQALE PLGDSKPDWK IFQAIANRLG FDWNYKHPSE 750
IMDEVARLTP LYAGVSYDRL EGFNSLQWPV QPDGTDEPIL YLEGFNFDNG 800
KAKLFPLSFD NYFKQDEIYD IHVNNGRLLE HFHEGNMTYQ TPMIKYKVPR 850
AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 900
NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIT KRGKSPLNPN 950
NFRVNKKRHP QYSVQVQKKW ERSDYVFPGN QVDK 984
Length:984
Mass (Da):111,295
Last modified:July 5, 2004 - v1
Checksum:i79140674B6A0C1D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB96094.1.
RefSeqiNP_647046.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB96094; BAB96094; BAB96094.
GeneIDi1004347.
KEGGisam:MW2229.
PATRICi19571186. VBIStaAur44266_2303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB96094.1 .
RefSeqi NP_647046.1. NC_003923.1.

3D structure databases

ProteinModelPortali Q7A057.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW2229.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB96094 ; BAB96094 ; BAB96094 .
GeneIDi 1004347.
KEGGi sam:MW2229.
PATRICi 19571186. VBIStaAur44266_2303.

Phylogenomic databases

eggNOGi COG3383.
HOGENOMi HOG000031440.
KOi K00123.
OMAi VAATWIK.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci SAUR196620:GJ9Z-2306-MONOMER.

Family and domain databases

InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036643. FDH_alpha. 1 hit.
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiFDHL_STAAW
AccessioniPrimary (citable) accession number: Q7A057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi