3-hydroxy-3-methylglutaryl CoA synthase - Staphylococcus aureus (strain MW2)

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Q79ZY6 (Q79ZY6_STAAW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 50. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
3-hydroxy-3-methylglutaryl CoA synthase EMBL BAB96332.1

Gene names

Name:	mvaS EMBL BAB96332.1
Ordered Locus Names:	MW2467

Organism

Staphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 1XPK PDB 1XPL PDB 1XPM Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	hydroxymethylglutaryl-CoA synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q79ZY6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: DB97F07344F353FA
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388

43,206

        10         20         30         40         50         60 
MTIGIDKINF YVPKYYVDMA KLAEARQVDP NKFLIGIGQT EMAVSPVNQD IVSMGANAAK 

        70         80         90        100        110        120 
DIITDEDKKK IGMVIVATES AVDAAKAAAV QIHNLLGIQP FARCFEMKEA CYAATPAIQL 

       130        140        150        160        170        180 
AKDYLATRPN EKVLVIATDT ARYGLNSGGE PTQGAGAVAM VIAHNPSILA LNEDAVAYTE 

       190        200        210        220        230        240 
DVYDFWRPTG HKYPLVDGAL SKDAYIRSFQ QSWNEYAKRQ GKSLADFASL CFHVPFTKMG 

       250        260        270        280        290        300 
KKALESIIDN ADETTQERLR SGYEDAVDYN RYVGNIYTGS LYLSLISLLE NRDLQAGETI 

       310        320        330        340        350        360 
GLFSYGSGSV GEFYSATLVE GYKDHLDQAA HKALLNNRTE VSVDAYETFF KRFDDVEFDE 

       370        380 
EQDAVHEDRH IFYLSNIENN VREYHRPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome and virulence determinants of high virulence community-acquired MRSA." Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K. Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"." Theisen M.J., Misra I., Saadat D., Campobasso N., Miziorko H.M., Harrison D.H. Proc. Natl. Acad. Sci. U.S.A. 101:16442-16447(2004) [PubMed: 15498869] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 3-388.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000033 Genomic DNA. Translation: BAB96332.1.

RefSeq

NP_647284.1. NC_003923.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XPK	X-ray	2.00	A/B/C/D	1-388	[»]
1XPL	X-ray	2.00	A/B/C/D	3-388	[»]
1XPM	X-ray	1.60	A/B/C/D	3-388	[»]

ProteinModelPortal

SMR

Q79ZY6. Positions 2-388.

ModBase

Protein-protein interaction databases

STRING

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

EBSTAT00000027228; EBSTAP00000026267; EBSTAG00000027227.

GeneID

GenomeReviews

Gene locus MW2467 in contig BA000033_GR.

KEGG

PATRIC

19571676. VBIStaAur44266_2549.

Organism-specific databases

CMR

Phylogenomic databases

eggNOG

GeneTree

EBGT00050000025370.

HOGENOM

OMA

ProtClustDB

Enzyme and pathway databases

BioCyc

SAUR196620:MW2467-MONOMER.

Family and domain databases

InterPro

IPR013746. HMG_CoA_synt_C.
IPR013528. HMG_CoA_synth_N.
IPR011554. HMG_CoA_synthase_prok.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]

Gene3D

G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.

KO

Pfam

PF08540. HMG_CoA_synt_C. 2 hits.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]

SUPFAM

SSF53901. Thiolase-like. 2 hits.

TIGRFAMs

TIGR01835. HMG-CoA-S_prok. 1 hit.

ProtoNet

Entry information

Entry name

Q79ZY6_STAAW

Accession

Primary (citable) accession number: Q79ZY6

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info