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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Iron (heme A axial ligand)Curated1
Metal bindingi265Copper BCurated1
Metal bindingi269Copper BCurated1
Metal bindingi314Copper BCurated1
Metal bindingi315Copper BCurated1
Metal bindingi398Iron (heme A3 axial ligand)Curated1
Metal bindingi400Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciCORYNE:G18NG-12127-MONOMER.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:Cgl2523, cg2780
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834401 – 584Cytochrome c oxidase subunit 1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase. The 4 subunit cytochrome c oxidase forms a supercomplex with the menaquinol-cytochrome c reductase complex (cytochrome bc1).1 Publication

Protein-protein interaction databases

STRINGi196627.cg2780.

Structurei

3D structure databases

ProteinModelPortaliQ79VD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiFFWIFGH.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q79VD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVAPRVDG HVAPQRPEPT GHARKGSKAW LMMTTTDHKQ LGIMYIIMSF
60 70 80 90 100
SFFFLGGLMA LLIRAELFTP GLQFLSNEQF NQLFTMHGTV MLLLYGTPIV
110 120 130 140 150
WGFANYVLPL QIGAPDVAFP RLNAFGFWIT TVGGVAMLTG FLTPGGAADF
160 170 180 190 200
GWTMYSPLSD AIHSPGLGSD MWIVGVGATG IGSVASAINM LTTILCLRAP
210 220 230 240 250
GMTMFRMPIF TWNIFVVSVL ALLIFPLLLA AALGVLYDRK LGGHLYDPAN
260 270 280 290 300
GGSLLWQHLF WFFGHPEVYV LALPFFGIVS EIIPVFSRKP MFGYVGLIFA
310 320 330 340 350
TLSIGALSMA VWAHHMFVTG AVLLPFFSFM TFLISVPTGV KFFNWVGTMW
360 370 380 390 400
KGHITWETPM IWSVGFMATF LFGGLTGIML ASPPLDFHLA DSYFLIAHFH
410 420 430 440 450
YTLFGTVVFA SCAGVYFWFP KMTGRMMDER LGKIHFWLTF VGFHGTFLIQ
460 470 480 490 500
HWVGNMGMPR RYADYLDSDG FTIYNQISTV FSFLLGLSVI PFIWNVFKSW
510 520 530 540 550
RYGELVTVDD PWGYGNSLEW ATSCPPPRHN FASLPRIRSE RPAFELHYPH
560 570 580
MIERMRAEAH TGHHDDINAP ELGTAPALAS DSSR
Length:584
Mass (Da):65,102
Last modified:July 5, 2004 - v1
Checksum:i10492DE9D173C4E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti554R → S in BAB64406 (PubMed:11577165).Curated1

Mass spectrometryi

Molecular mass is 64955.8±164.1 Da from positions 1 - 584. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306417 Genomic DNA. Translation: CAC33824.1.
AB052748 Genomic DNA. Translation: BAB64406.1.
BA000036 Genomic DNA. Translation: BAB99916.1.
BX927155 Genomic DNA. Translation: CAF21186.1.
RefSeqiNP_601724.2. NC_003450.3.
WP_011015188.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99916; BAB99916; BAB99916.
CAF21186; CAF21186; cg2780.
GeneIDi1020472.
KEGGicgb:cg2780.
cgl:NCgl2437.
PATRICi21497064. VBICorGlu203724_2457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306417 Genomic DNA. Translation: CAC33824.1.
AB052748 Genomic DNA. Translation: BAB64406.1.
BA000036 Genomic DNA. Translation: BAB99916.1.
BX927155 Genomic DNA. Translation: CAF21186.1.
RefSeqiNP_601724.2. NC_003450.3.
WP_011015188.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ79VD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg2780.

Protein family/group databases

TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB99916; BAB99916; BAB99916.
CAF21186; CAF21186; cg2780.
GeneIDi1020472.
KEGGicgb:cg2780.
cgl:NCgl2437.
PATRICi21497064. VBICorGlu203724_2457.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiFFWIFGH.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciCORYNE:G18NG-12127-MONOMER.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_CORGL
AccessioniPrimary (citable) accession number: Q79VD7
Secondary accession number(s): Q93HZ5, Q9AEL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.