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Q79VD7

- COX1_CORGL

UniProt

Q79VD7 - COX1_CORGL

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Protein

Cytochrome c oxidase subunit 1

Gene
ctaD, Cgl2523, cg2780
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron (heme A axial ligand) Inferred
Metal bindingi265 – 2651Copper B Inferred
Metal bindingi269 – 2691Copper B Inferred
Metal bindingi314 – 3141Copper B Inferred
Metal bindingi315 – 3151Copper B Inferred
Metal bindingi398 – 3981Iron (heme A3 axial ligand) Inferred
Metal bindingi400 – 4001Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:Cgl2523, cg2780
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei122 – 14221Helical; Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Reviewed predictionAdd
BLAST
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Transmembranei259 – 27921Helical; Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Reviewed predictionAdd
BLAST
Transmembranei316 – 33621Helical; Reviewed predictionAdd
BLAST
Transmembranei360 – 38021Helical; Reviewed predictionAdd
BLAST
Transmembranei399 – 41921Helical; Reviewed predictionAdd
BLAST
Transmembranei434 – 45421Helical; Reviewed predictionAdd
BLAST
Transmembranei477 – 49721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Cytochrome c oxidase subunit 1PRO_0000183440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase. The 4 subunit cytochrome c oxidase forms a supercomplex with the menaquinol-cytochrome c reductase complex (cytochrome bc1).1 Publication

Protein-protein interaction databases

STRINGi196627.cg2780.

Structurei

3D structure databases

ProteinModelPortaliQ79VD7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OMAiISETVCA.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q79VD7-1 [UniParc]FASTAAdd to Basket

« Hide

MTAVAPRVDG HVAPQRPEPT GHARKGSKAW LMMTTTDHKQ LGIMYIIMSF    50
SFFFLGGLMA LLIRAELFTP GLQFLSNEQF NQLFTMHGTV MLLLYGTPIV 100
WGFANYVLPL QIGAPDVAFP RLNAFGFWIT TVGGVAMLTG FLTPGGAADF 150
GWTMYSPLSD AIHSPGLGSD MWIVGVGATG IGSVASAINM LTTILCLRAP 200
GMTMFRMPIF TWNIFVVSVL ALLIFPLLLA AALGVLYDRK LGGHLYDPAN 250
GGSLLWQHLF WFFGHPEVYV LALPFFGIVS EIIPVFSRKP MFGYVGLIFA 300
TLSIGALSMA VWAHHMFVTG AVLLPFFSFM TFLISVPTGV KFFNWVGTMW 350
KGHITWETPM IWSVGFMATF LFGGLTGIML ASPPLDFHLA DSYFLIAHFH 400
YTLFGTVVFA SCAGVYFWFP KMTGRMMDER LGKIHFWLTF VGFHGTFLIQ 450
HWVGNMGMPR RYADYLDSDG FTIYNQISTV FSFLLGLSVI PFIWNVFKSW 500
RYGELVTVDD PWGYGNSLEW ATSCPPPRHN FASLPRIRSE RPAFELHYPH 550
MIERMRAEAH TGHHDDINAP ELGTAPALAS DSSR 584
Length:584
Mass (Da):65,102
Last modified:July 5, 2004 - v1
Checksum:i10492DE9D173C4E6
GO

Mass spectrometryi

Molecular mass is 64955.8±164.1 Da from positions 1 - 584. Determined by MALDI. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti554 – 5541R → S in BAB64406. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ306417 Genomic DNA. Translation: CAC33824.1.
AB052748 Genomic DNA. Translation: BAB64406.1.
BA000036 Genomic DNA. Translation: BAB99916.1.
BX927155 Genomic DNA. Translation: CAF21186.1.
RefSeqiNP_601724.2. NC_003450.3.
WP_011015188.1. NC_006958.1.
YP_226765.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99916; BAB99916; BAB99916.
CAF21186; CAF21186; cg2780.
GeneIDi1020472.
KEGGicgb:cg2780.
cgl:NCgl2437.
PATRICi21497064. VBICorGlu203724_2457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ306417 Genomic DNA. Translation: CAC33824.1 .
AB052748 Genomic DNA. Translation: BAB64406.1 .
BA000036 Genomic DNA. Translation: BAB99916.1 .
BX927155 Genomic DNA. Translation: CAF21186.1 .
RefSeqi NP_601724.2. NC_003450.3.
WP_011015188.1. NC_006958.1.
YP_226765.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q79VD7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg2780.

Protein family/group databases

TCDBi 3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99916 ; BAB99916 ; BAB99916 .
CAF21186 ; CAF21186 ; cg2780 .
GeneIDi 1020472.
KEGGi cgb:cg2780.
cgl:NCgl2437.
PATRICi 21497064. VBICorGlu203724_2457.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OMAi ISETVCA.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the cytochrome bc1-aa3 branch of the Corynebacterium glutamicum respiratory chain containing an unusual diheme cytochrome c1."
    Niebisch A., Bott M.
    Arch. Microbiol. 175:282-294(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "Cytochrome c oxidase contains an extra charged amino acid cluster in a new type of respiratory chain in the amino acid-producing Gram-positive bacterium Corynebacterium glutamicum."
    Sakamoto J., Shibata T., Mine T., Miyahara R., Torigoe T., Noguchi S., Matsushita K., Sone N.
    Microbiology 147:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, HEME CHARACTERIZATION, MASS SPECTROMETRY.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  5. "Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1."
    Niebisch A., Bott M.
    J. Biol. Chem. 278:4339-4346(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DETECTION IN A SUPERCOMPLEX WITH MENAQUINOL-CYTOCHROME C REDUCTASE (CYTOCHROME BC1).
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiCOX1_CORGL
AccessioniPrimary (citable) accession number: Q79VD7
Secondary accession number(s): Q93HZ5, Q9AEL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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