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Protein

Beta-lactamase

Gene

blaIMP-1

Organism
Pseudomonas aeruginosa
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

Cofactori

Zn2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Zinc 1; via tele nitrogenCombined sources1
Metal bindingi95Zinc 2; via tele nitrogenCombined sources1
Metal bindingi97Zinc 2; via pros nitrogenCombined sources1
Metal bindingi99Zinc 3Combined sources1
Metal bindingi157Zinc 2; via tele nitrogenCombined sources1
Metal bindingi176Zinc 3Combined sources1
Metal bindingi215Zinc 3; via tele nitrogenCombined sources1
Metal bindingi217Zinc 1Combined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processAntibiotic resistanceUniRule annotation
LigandMetal-bindingUniRule annotationCombined sources, ZincUniRule annotationCombined sources

Enzyme and pathway databases

BRENDAi3.5.2.6 5087

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
Gene namesi
Name:blaIMP-1Imported
Synonyms:bla IMPImported, bla-impImported, blaESPImported, impImported
Encoded oniPlasmid pMS350Imported
OrganismiPseudomonas aeruginosaImported
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1293244
DrugBankiDB02154 2,3-Bis-Benzo[1,3]Dioxol-5-Ylmethyl-Succinic Acid
DB02450 2-Benzo[1,3]Dioxol-5-Ylmethyl-3-Benzyl-Succinic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501458762919 – 246Beta-lactamaseSequence analysisAdd BLAST228

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DDKX-ray3.10A20-239[»]
1JJEX-ray1.80A/B19-240[»]
1JJTX-ray1.80A/B19-246[»]
3WXCX-ray2.10A/B19-240[»]
4F6HX-ray1.74A19-246[»]
4F6ZX-ray2.00A19-246[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 215Lactamase_BInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001018 Beta-lactamase_class-B_CS
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
PROSITEiView protein in PROSITE
PS00743 BETA_LACTAMASE_B_1, 1 hit
PS00744 BETA_LACTAMASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q79MP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSVFFIF LFCSIATAAE SLPDLKIEKL DEGVYVHTSF EEVNGWGVVP
60 70 80 90 100
KHGLVVLVNA EAYLIDTPFT AKDTEKLVTW FVERGYKIKG SISSHFHSDS
110 120 130 140 150
TGGIEWLNSR SIPTYASELT NELLKKDGKV QATNSFSGVN YWLVKNKIEV
160 170 180 190 200
FYPGPGHTPD NVVVWLPERK ILFGGCFIKP YGLGNLGDAN IEAWPKSAKL
210 220 230 240
LKSKYGKAKL VVPSHSEVGD ASLLKLTLEQ AVKGLNESKK PSKPSN
Length:246
Mass (Da):27,120
Last modified:July 5, 2004 - v1
Checksum:i9B2599E8F1B22D36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei246Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168635 Genomic DNA Translation: AAN87168.1
AY625686 Genomic DNA Translation: AAT48073.1
AY625687 Genomic DNA Translation: AAT48074.1
AY625688 Genomic DNA Translation: AAT48075.1
AY625689 Genomic DNA Translation: AAT48076.1
DQ842025 Genomic DNA Translation: ABG67754.1
GU831546 Genomic DNA Translation: ADF36530.1
GU831547 Genomic DNA Translation: ADF36531.1
GU831548 Genomic DNA Translation: ADF36532.1
GU831549 Genomic DNA Translation: ADF36533.1
GU831550 Genomic DNA Translation: ADF36534.1
GU831551 Genomic DNA Translation: ADF36535.1
GU831552 Genomic DNA Translation: ADF36536.1
GU831553 Genomic DNA Translation: ADF36537.1
D78375 Genomic DNA Translation: BAA23768.1
AB104852 Genomic DNA Translation: BAD14385.1
AB462903 Genomic DNA Translation: BAH66387.1
AB472901 Genomic DNA Translation: BAN78520.1
AB901035 Genomic DNA Translation: BAO48002.1
AB901036 Genomic DNA Translation: BAO48007.1
AB901038 Genomic DNA Translation: BAO48013.1
AB901043 Genomic DNA Translation: BAO48031.1
AB901045 Genomic DNA Translation: BAO48035.1
AB983593 Genomic DNA Translation: BAP46406.1
AJ223604 Genomic DNA Translation: CAA11471.1
X98393 Genomic DNA Translation: CAA67040.1
RefSeqiWP_003159548.1, NZ_NXHR01000094.1

Genome annotation databases

PATRICifig|287.2578.peg.5183

Similar proteinsi

Entry informationi

Entry nameiQ79MP6_PSEAI
AccessioniPrimary (citable) accession number: Q79MP6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported

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