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Q79MP6 (Q79MP6_PSEAI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Beta-lactamase IMP-1 EMBL ABG67754.1

Bla-imp protein EMBL CAA11471.1

Extended-spectrum B-lactamase EMBL BAA23768.1

IMP-1 class B beta-lactamase EMBL BAO48007.1

IMP-1 class B metallo-beta-lactamase EMBL BAO48002.1

IMP-1 metallo-beta-lactmase EMBL BAD14385.1

Metallo beta lactamase EMBL BAH66387.1

Metallo-beta-lactamase EMBL AAT48073.1

Metallo-beta-lactamase IMP-1 EMBL AAN87168.1
Gene names
Name:blaIMP-1 EMBL AAN87168.1
Synonyms:bla IMP EMBL BAD14385.1, bla-imp EMBL CAA11471.1, blaESP EMBL BAA23768.1, imp EMBL CAA67040.1
Encoded onPlasmid pMS350 Ref.1 Ref.2 EMBL BAA23768.1
OrganismPseudomonas aeruginosa EMBL AAN87168.1
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region97 – 993Sulfate 2 binding PDB 4F6H
Region178 – 1792Phosphate 2 binding PDB 4F6H
Region214 – 2152Citrate binding PDB 4F6Z
Region215 – 2162Phosphate 2 binding PDB 4F6H

Sites

Metal binding521Zinc 1; via tele nitrogen PDB 1JJT PDB 1JJE
Metal binding951Zinc 2; via tele nitrogen PDB 4F6Z PDB 1DDK PDB 1JJT PDB 4F6H PDB 1JJE
Metal binding971Zinc 2; via pros nitrogen PDB 4F6Z PDB 1DDK PDB 1JJT PDB 4F6H PDB 1JJE
Metal binding991Zinc 3 PDB 1DDK PDB 1JJT PDB 1JJE
Metal binding1571Zinc 2; via tele nitrogen PDB 4F6Z PDB 1DDK PDB 1JJT PDB 4F6H PDB 1JJE
Metal binding1761Zinc 3 PDB 1DDK PDB 1JJT PDB 1JJE
Metal binding2151Zinc 3; via tele nitrogen PDB 1DDK PDB 1JJT PDB 1JJE
Metal binding2171Zinc 1 PDB 1JJT PDB 1JJE
Binding site261Acetate PDB 1JJT PDB 1JJE
Binding site461Sulfate 1 PDB 4F6H
Binding site521Acetate PDB 1JJT PDB 1JJE
Binding site991Citrate PDB 4F6Z
Binding site1421Phosphate 1 PDB 4F6H
Binding site1491Phosphate 1 PDB 4F6H
Binding site1571Sulfate 2 PDB 4F6H
Binding site1791Citrate PDB 4F6Z
Binding site1791Sulfate 2 PDB 4F6H
Binding site2151Sulfate 2 PDB 4F6H
Binding site2171Acetate PDB 1JJT PDB 1JJE

Experimental info

Non-terminal residue2461 EMBL CAA67040.1

Sequences

Sequence LengthMass (Da)Tools
Q79MP6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9B2599E8F1B22D36

FASTA24627,120
        10         20         30         40         50         60 
MSKLSVFFIF LFCSIATAAE SLPDLKIEKL DEGVYVHTSF EEVNGWGVVP KHGLVVLVNA 

        70         80         90        100        110        120 
EAYLIDTPFT AKDTEKLVTW FVERGYKIKG SISSHFHSDS TGGIEWLNSR SIPTYASELT 

       130        140        150        160        170        180 
NELLKKDGKV QATNSFSGVN YWLVKNKIEV FYPGPGHTPD NVVVWLPERK ILFGGCFIKP 

       190        200        210        220        230        240 
YGLGNLGDAN IEAWPKSAKL LKSKYGKAKL VVPSHSEVGD ASLLKLTLEQ AVKGLNESKK 


PSKPSN 

« Hide

References

[1]"Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance."
Osano E., Arakawa Y., Wacharotayankun R., Ohta M., Horii T., Ito H., Yoshimura F., Kato N.
Antimicrob. Agents Chemother. 38:71-78(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Insertion of a carbapenemase gene cassette into an integron of a Pseudomonas aeruginosa plasmid."
Iyobe S., Minami S., Yamada H.
J. Antimicrob. Chemother. 38:1114-1115(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]Laraki N., Rossolini G., Galleni M., Frere J.M.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]Galleni M.G.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[5]"Structure of In31, a blaIMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes."
Laraki N., Galleni M., Thamm I., Riccio M.L., Amicosante G., Frere J.M., Rossolini G.M.
Antimicrob. Agents Chemother. 43:890-901(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[6]"Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor."
Concha N.O., Janson C.A., Rowling P., Pearson S., Cheever C.A., Clarke B.P., Lewis C., Galleni M., Frere J.M., Payne D.J., Bateson J.H., Abdel-Meguid S.S.
Biochemistry 39:4288-4298(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 19-246 IN COMPLEX WITH SULFATE AND ZINC.
[7]"Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase."
Toney J.H., Hammond G.G., Fitzgerald P.M., Sharma N., Balkovec J.M., Rouen G.P., Olson S.H., Hammond M.L., Greenlee M.L., Gao Y.D.
J. Biol. Chem. 276:31913-31918(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 19-240 IN COMPLEX WITH ACETATE AND ZINC.
[8]"Clonal spread of IMP-1-producing Pseudomonas aeruginosa in two hospitals in Singapore."
Koh T.H., Wang G.C., Sng L.H.
J. Clin. Microbiol. 42:5378-5380(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DM14158/00 EMBL AAT48075.1, DU10114/00 EMBL AAT48073.1, DU32495/00 EMBL AAT48074.1, DU40799/00 EMBL AAN87168.1 and DU8622/00 EMBL AAT48076.1.
[9]"Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase."
Sekiguchi J., Asagi T., Miyoshi-Akiyama T., Fujino T., Kobayashi I., Morita K., Kikuchi Y., Kuratsuji T., Kirikae T.
Antimicrob. Agents Chemother. 49:3734-3742(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IMCJ2.S1 EMBL BAD14385.1.
[10]"Molecular epidemiology of clinical Pseudomonas aeruginosa isolates carrying IMP-1 metallo-beta-lactamase gene in a University Hospital in Turkey."
Ozgumus O.B., Caylan R., Tosun I., Sandalli C., Aydin K., Koksal I.
Microb. Drug Resist. 13:191-198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[11]Kitao-Ando T., Miyoshi-Akiyama T., Kirikae T.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IMCJ798 EMBL BAH66387.1.
[12]"AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates."
Kitao T., Miyoshi-Akiyama T., Kirikae T.
Antimicrob. Agents Chemother. 53:2327-2334(2009)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IMCJ798 EMBL BAH66387.1.
[13]Polotto M., Nogueira M.L., Nogueira M.C.L.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PHB 2 EMBL ADF36530.1, PHB 3 EMBL ADF36531.1, PHB 49 EMBL ADF36532.1, PHB 51 EMBL ADF36533.1, PHB 53 EMBL ADF36534.1, PHB 59 EMBL ADF36535.1, PHB 60 EMBL ADF36536.1 and PHB 62 EMBL ADF36537.1.
[14]"Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-?-lactamase active site."
Horton L.B., Shanker S., Mikulski R., Brown N.G., Phillips K.J., Lykissa E., Venkataram Prasad B.V., Palzkill T.
Antimicrob. Agents Chemother. 56:5667-5677(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 19-246 IN COMPLEX WITH CITRATE; PHOSPHATE; SULFATE AND ZINC.
[15]"Identification and Characterization of a Novel aac(6')-Iag Associated with the bla IMP-1-Integron in a Multidrug-Resistant Pseudomonas aeruginosa."
Kobayashi K., Hayashi I., Kouda S., Kato F., Fujiwara T., Kayama S., Hirakawa H., Itaha H., Ohge H., Gotoh N., Usui T., Matsubara A., Sugai M.
PLoS ONE 8:e70557-e70557(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NK0009 EMBL BAN78520.1.
[16]"Diversity of metallo-beta-lactamase genes and integron structures among clinical isolates of Pseudomonas aeruginosa in Japan."
Mano Y., Ishii Y., Yoshizumi Y., Saga T., Furuya N., Yamaguchi K., Tateda K.
Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: TUM3982 EMBL BAO48002.1, TUM3987 EMBL BAO48007.1, TUM3992 EMBL BAO48035.1, TUM4027 EMBL BAO48013.1 and TUM4032 EMBL BAO48031.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY168635 Genomic DNA. Translation: AAN87168.1.
AY625686 Genomic DNA. Translation: AAT48073.1.
AY625687 Genomic DNA. Translation: AAT48074.1.
AY625688 Genomic DNA. Translation: AAT48075.1.
AY625689 Genomic DNA. Translation: AAT48076.1.
DQ842025 Genomic DNA. Translation: ABG67754.1.
GU831546 Genomic DNA. Translation: ADF36530.1.
GU831547 Genomic DNA. Translation: ADF36531.1.
GU831548 Genomic DNA. Translation: ADF36532.1.
GU831549 Genomic DNA. Translation: ADF36533.1.
GU831550 Genomic DNA. Translation: ADF36534.1.
GU831551 Genomic DNA. Translation: ADF36535.1.
GU831552 Genomic DNA. Translation: ADF36536.1.
GU831553 Genomic DNA. Translation: ADF36537.1.
D78375 Genomic DNA. Translation: BAA23768.1.
AB104852 Genomic DNA. Translation: BAD14385.1.
AB462903 Genomic DNA. Translation: BAH66387.1.
AB472901 Genomic DNA. Translation: BAN78520.1.
AB901035 Genomic DNA. Translation: BAO48002.1.
AB901036 Genomic DNA. Translation: BAO48007.1.
AB901038 Genomic DNA. Translation: BAO48013.1.
AB901043 Genomic DNA. Translation: BAO48031.1.
AB901045 Genomic DNA. Translation: BAO48035.1.
AJ223604 Genomic DNA. Translation: CAA11471.1.
X98393 Genomic DNA. Translation: CAA67040.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DDKX-ray3.10A20-239[»]
1JJEX-ray1.80A/B19-240[»]
1JJTX-ray1.80A/B19-246[»]
4F6HX-ray1.74A19-246[»]
4F6ZX-ray2.00A19-246[»]
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1293244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.15.10. 1 hit.
InterProIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMSSF56281. SSF56281. 1 hit.
PROSITEPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ79MP6.

Entry information

Entry nameQ79MP6_PSEAI
AccessionPrimary (citable) accession number: Q79MP6
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)