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Protein

Glucanase

Gene

celA1

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168UniRule annotation1
Binding sitei168GlucoseCombined sources1
Active sitei206Proton donorUniRule annotation1
Binding sitei206GlucoseCombined sources1
Binding sitei277GlucoseCombined sources1
Binding sitei319GlucoseCombined sources1
Active sitei353NucleophileUniRule annotation1

GO - Molecular functioni

  • cellulase activity Source: MTBBASE

GO - Biological processi

  • cellulose catabolic process Source: MTBBASE

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradationUniRule annotation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucanaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:celA1Imported
Ordered Locus Names:Rv0062Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular region Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB03584. 4-Thio-beta-D-glucopyranose.
DB04545. Afegostat.
DB02379. Beta-D-Glucose.
DB02467. L-methionine (S)-S-oxide.
DB01642. O1-Methyl-Glucose.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi169 ↔ 213Combined sources
Disulfide bondi320 ↔ 356Combined sources

Proteomic databases

PaxDbiQ79G13.
PRIDEiQ79G13.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0062.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UOZX-ray1.10A88-380[»]
1UP0X-ray1.75A88-380[»]
1UP2X-ray1.90A88-380[»]
1UP3X-ray1.60A88-380[»]
ProteinModelPortaliQ79G13.
SMRiQ79G13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase family 6.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4108W9Q. Bacteria.
COG5297. LUCA.
HOGENOMiHOG000019501.
KOiK01179.
OMAiFDAHFIV.
PhylomeDBiQ79G13.

Family and domain databases

Gene3Di3.20.20.40. 1 hit.
InterProiView protein in InterPro
IPR016288. Beta_cellobiohydrolase.
IPR036434. Beta_cellobiohydrolase_sf.
PANTHERiPTHR34876. PTHR34876. 1 hit.
PfamiView protein in Pfam
PF01341. Glyco_hydro_6. 1 hit.
PIRSFiPIRSF001100. Beta_cellobiohydrolase. 1 hit.
PRINTSiPR00733. GLHYDRLASE6.
SUPFAMiSSF51989. SSF51989. 1 hit.

Sequencei

Sequence statusi: Complete.

Q79G13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRTGQRWR GTLPGRRPWT RPAPATCRRH LAFVELRHYF ARVMSSAIGS
60 70 80 90 100
VARWIVPLLG VAAVASIGVI ADPVRVVRAP ALILVDAANP LAGKPFYVDP
110 120 130 140 150
ASAAMVAARN ANPPNAELTS VANTPQSYWL DQAFPPATVG GTVARYTGAA
160 170 180 190 200
QAAGAMPVLT LYGIPHRDCG SYASGGFATG TDYRGWIDAV ASGLGSSPAT
210 220 230 240 250
IIVEPDALAM ADCLSPDQRQ ERFDLVRYAV DTLTRDPAAA VYVDAGHSRW
260 270 280 290 300
LSAEAMAARL NDVGVGRARG FSLNVSNFYT TDEEIGYGEA ISGLTNGSHY
310 320 330 340 350
VIDTSRNGAG PAPDAPLNWC NPSGRALGAP PTTATAGAHA DAYLWIKRPG
360 370 380
ESDGTCGRGE PQAGRFVSQY AIDLAHNAGQ
Length:380
Mass (Da):39,974
Last modified:July 5, 2004 - v1
Checksum:iAAA8F1BD10C4CB68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42784.1.
RefSeqiWP_003400562.1. NZ_KK339370.1.
YP_177689.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP42784; CCP42784; Rv0062.
GeneIDi887007.
KEGGimtu:Rv0062.
mtv:RVBD_0062.
PATRICifig|83332.111.peg.70.

Similar proteinsi

Entry informationi

Entry nameiQ79G13_MYCTU
AccessioniPrimary (citable) accession number: Q79G13
Secondary accession number(s): F2GPR5, I6Y6T1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported