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Protein

Glucanase

Gene

celA1

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681UniRule annotation
Binding sitei168 – 1681GlucoseCombined sources
Active sitei206 – 2061Proton donorUniRule annotation
Binding sitei206 – 2061GlucoseCombined sources
Binding sitei277 – 2771GlucoseCombined sources
Binding sitei319 – 3191GlucoseCombined sources
Active sitei353 – 3531NucleophileUniRule annotation

GO - Molecular functioni

  • cellulase activity Source: MTBBASE

GO - Biological processi

  • cellulose catabolic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradationUniRule annotation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucanaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:celA1Imported
Ordered Locus Names:Rv0062Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi169 ↔ 213Combined sources
Disulfide bondi320 ↔ 356Combined sources

Proteomic databases

PaxDbiQ79G13.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0062.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UOZX-ray1.10A88-380[»]
1UP0X-ray1.75A88-380[»]
1UP2X-ray1.90A88-380[»]
1UP3X-ray1.60A88-380[»]
ProteinModelPortaliQ79G13.
SMRiQ79G13. Positions 88-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase family 6.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4108W9Q. Bacteria.
COG5297. LUCA.
HOGENOMiHOG000019501.
KOiK01179.
OMAiMAYAGKA.
PhylomeDBiQ79G13.

Family and domain databases

Gene3Di3.20.20.40. 1 hit.
InterProiIPR016288. Beta_cellobiohydrolase.
[Graphical view]
PfamiPF01341. Glyco_hydro_6. 1 hit.
[Graphical view]
PIRSFiPIRSF001100. Beta_cellobiohydrolase. 1 hit.
PRINTSiPR00733. GLHYDRLASE6.
SUPFAMiSSF51989. SSF51989. 1 hit.

Sequencei

Sequence statusi: Complete.

Q79G13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRTGQRWR GTLPGRRPWT RPAPATCRRH LAFVELRHYF ARVMSSAIGS
60 70 80 90 100
VARWIVPLLG VAAVASIGVI ADPVRVVRAP ALILVDAANP LAGKPFYVDP
110 120 130 140 150
ASAAMVAARN ANPPNAELTS VANTPQSYWL DQAFPPATVG GTVARYTGAA
160 170 180 190 200
QAAGAMPVLT LYGIPHRDCG SYASGGFATG TDYRGWIDAV ASGLGSSPAT
210 220 230 240 250
IIVEPDALAM ADCLSPDQRQ ERFDLVRYAV DTLTRDPAAA VYVDAGHSRW
260 270 280 290 300
LSAEAMAARL NDVGVGRARG FSLNVSNFYT TDEEIGYGEA ISGLTNGSHY
310 320 330 340 350
VIDTSRNGAG PAPDAPLNWC NPSGRALGAP PTTATAGAHA DAYLWIKRPG
360 370 380
ESDGTCGRGE PQAGRFVSQY AIDLAHNAGQ
Length:380
Mass (Da):39,974
Last modified:July 5, 2004 - v1
Checksum:iAAA8F1BD10C4CB68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42784.1.
RefSeqiWP_003400562.1. NC_000962.3.
YP_177689.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP42784; CCP42784; Rv0062.
GeneIDi887007.
KEGGimtu:Rv0062.
mtv:RVBD_0062.
PATRICi18148631. VBIMycTub87468_0069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42784.1.
RefSeqiWP_003400562.1. NC_000962.3.
YP_177689.1. NC_000962.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UOZX-ray1.10A88-380[»]
1UP0X-ray1.75A88-380[»]
1UP2X-ray1.90A88-380[»]
1UP3X-ray1.60A88-380[»]
ProteinModelPortaliQ79G13.
SMRiQ79G13. Positions 88-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0062.

Proteomic databases

PaxDbiQ79G13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42784; CCP42784; Rv0062.
GeneIDi887007.
KEGGimtu:Rv0062.
mtv:RVBD_0062.
PATRICi18148631. VBIMycTub87468_0069.

Phylogenomic databases

eggNOGiENOG4108W9Q. Bacteria.
COG5297. LUCA.
HOGENOMiHOG000019501.
KOiK01179.
OMAiMAYAGKA.
PhylomeDBiQ79G13.

Family and domain databases

Gene3Di3.20.20.40. 1 hit.
InterProiIPR016288. Beta_cellobiohydrolase.
[Graphical view]
PfamiPF01341. Glyco_hydro_6. 1 hit.
[Graphical view]
PIRSFiPIRSF001100. Beta_cellobiohydrolase. 1 hit.
PRINTSiPR00733. GLHYDRLASE6.
SUPFAMiSSF51989. SSF51989. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 88-380 IN COMPLEX WITH GLUCOSE, DISULFIDE BONDS.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ79G13_MYCTU
AccessioniPrimary (citable) accession number: Q79G13
Secondary accession number(s): F2GPR5, I6Y6T1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.