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Q79FJ2 (Q79FJ2_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd1 EMBL CAE55437.1
Ordered Locus Names:Rv1844c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding17 – 226NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding40 – 423NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding82 – 843NADP By similarity PIRSR PIRSR000109-3
Region138 – 1403Substrate binding By similarity PIRSR PIRSR000109-2
Region195 – 1962Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1921Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1991Proton donor By similarity PIRSR PIRSR000109-1
Binding site1121NADP By similarity PIRSR PIRSR000109-3
Binding site1121Substrate By similarity PIRSR PIRSR000109-2
Binding site2001Substrate By similarity PIRSR PIRSR000109-2
Binding site2701Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2971Substrate By similarity PIRSR PIRSR000109-2
Binding site4551Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4611Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q79FJ2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B56FFC44B54E38B2

FASTA48551,547
        10         20         30         40         50         60 
MSSSESPAGI AQIGVTGLAV MGSNIARNFA RHGYTVAVHN RSVAKTDALL KEHSSDGKFV 

        70         80         90        100        110        120 
RSETIPEFLA ALEKPRRVLI MVKAGEATDA DAVINELADA MEPGDIIIDG GNALYTDTMR 

       130        140        150        160        170        180 
REKAMRERGL HFVGAGISGG EEGALNGPSI MPGGPAESYQ SLGPLLEEIS AHVDGVPCCT 

       190        200        210        220        230        240 
HIGPDGSGHF VKMVHNGIEY SDMQLIGEAY QLMRDGLGLT APAIADVFTE WNNGDLDSYL 

       250        260        270        280        290        300 
VEITAEVLRQ TDAKTGKPLV DVIVDRAEQK GTGRWTVKSA LDLGVPVTGI AEAVFARALS 

       310        320        330        340        350        360 
GSVGQRSAAS GLASGKLGEQ PADPATFTED VRQALYASKI VAYAQGFNQI QAGSAEFGWD 

       370        380        390        400        410        420 
ITPGDLATIW RGGCIIRAKF LNHIKEAFDA SPNLASLIVA PYFRGAVESA IDSWRRVVST 

       430        440        450        460        470        480 
AAQLGIPTPG FSSALSYYDA LRTARLPAAL TQAQRDFFGA HTYGRIDEPG KFHTLWSSDR 


TEVPV

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842578 Genomic DNA. Translation: CAE55437.1.
PIRD70664.
RefSeqYP_177848.1. NC_000962.2.

3D structure databases

ProteinModelPortalQ79FJ2.
SMRQ79FJ2. Positions 11-480.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001880; EBMYCP00000001880; EBMYCG00000001878.
GeneID885755.
GenomeReviewsGene locus Rv1844c in contig AL123456_GR.
KEGGmtu:Rv1844c.
PATRIC18152652. VBIMycTub87468_2056.

Organism-specific databases

TubercuListRv1844c.

Phylogenomic databases

GeneTreeEBGT00050000015862.
HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBQ79FJ2.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ79FJ2_MYCTU
AccessionPrimary (citable) accession number: Q79FJ2
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info