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Protein

PPE family protein PPE41

Gene

PPE41

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The PE25/PPE41 dimer induces both a strong humoral and cellular immune response (PubMed:18974870). The dimer induces necrosis, but not apoptosis, in mouse macrophage cells (PubMed:25379378). It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses (PubMed:26318856).3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciMTBRV:RV2430C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PPE family protein PPE41Curated
Gene namesi
Name:PPE41Imported
Ordered Locus Names:Rv2430cImported
ORF Names:LH57_13290Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2430c.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • extracellular region Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi124 – 1241A → L: Does not disrupt the interaction with EspG5. 1 Publication
Mutagenesisi125 – 1251L → E or R: Does not affect formation of the PE25/PPE41 dimer, but abolishes EspG5 binding to PE25/PPE41. 1 Publication
Mutagenesisi127 – 1271Q → I: Does not disrupt the interaction with EspG5. 1 Publication
Mutagenesisi129 – 1302TA → DR: Does not affect formation of the PE25/PPE41 dimer, but abolishes EspG5 binding to PE25/PPE41. 1 Publication
Mutagenesisi130 – 1301A → I: Does not disrupt the interaction with EspG5. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194PPE family protein PPE41PRO_0000435111Add
BLAST

Interactioni

Subunit structurei

Forms a heterodimer with PE25. The dimer forms a 1:1:1 heterotrimeric complex with EspG5. PPE41 interacts directly with EspG5.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MT2506Q7D7562EBI-8063017,EBI-8063031From a different organism.

Protein-protein interaction databases

DIPiDIP-42564N.
IntActiQ79FE1. 1 interaction.
MINTiMINT-1781252.
STRINGi83332.Rv2430c.

Structurei

Secondary structure

1
194
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Helixi8 – 1710Combined sources
Helixi22 – 4928Combined sources
Turni50 – 556Combined sources
Helixi59 – 679Combined sources
Helixi69 – 10234Combined sources
Helixi106 – 12116Combined sources
Helixi129 – 16234Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G38X-ray2.20B/D1-194[»]
4KXRX-ray2.60B1-194[»]
4W4KX-ray1.95B/D1-174[»]
4W4LX-ray2.45B1-174[»]
ProteinModelPortaliQ79FE1.
SMRiQ79FE1. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mycobacterial PPE family.Curated

Phylogenomic databases

HOGENOMiHOG000220519.
PhylomeDBiQ79FE1.

Family and domain databases

InterProiIPR000030. PPE_family.
[Graphical view]
PfamiPF00823. PPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q79FE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFEAYPPEV NSANIYAGPG PDSMLAAARA WRSLDVEMTA VQRSFNRTLL
60 70 80 90 100
SLMDAWAGPV VMQLMEAAKP FVRWLTDLCV QLSEVERQIH EIVRAYEWAH
110 120 130 140 150
HDMVPLAQIY NNRAERQILI DNNALGQFTA QIADLDQEYD DFWDEDGEVM
160 170 180 190
RDYRLRVSDA LSKLTPWKAP PPIAHSTVLV APVSPSTASS RTDT
Length:194
Mass (Da):21,943
Last modified:July 5, 2004 - v1
Checksum:i85F63AA653B04D75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45222.1.
CP009480 Genomic DNA. Translation: AIR15197.1.
RefSeqiWP_003412549.1. NZ_KK339370.1.
YP_177881.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiAIR15197; AIR15197; LH57_13290.
CCP45222; CCP45222; Rv2430c.
GeneIDi885945.
KEGGimtu:Rv2430c.
mtv:RVBD_2430c.
PATRICi18153997. VBIMycTub87468_2722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45222.1.
CP009480 Genomic DNA. Translation: AIR15197.1.
RefSeqiWP_003412549.1. NZ_KK339370.1.
YP_177881.1. NC_000962.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G38X-ray2.20B/D1-194[»]
4KXRX-ray2.60B1-194[»]
4W4KX-ray1.95B/D1-174[»]
4W4LX-ray2.45B1-174[»]
ProteinModelPortaliQ79FE1.
SMRiQ79FE1. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-42564N.
IntActiQ79FE1. 1 interaction.
MINTiMINT-1781252.
STRINGi83332.Rv2430c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR15197; AIR15197; LH57_13290.
CCP45222; CCP45222; Rv2430c.
GeneIDi885945.
KEGGimtu:Rv2430c.
mtv:RVBD_2430c.
PATRICi18153997. VBIMycTub87468_2722.

Organism-specific databases

TubercuListiRv2430c.

Phylogenomic databases

HOGENOMiHOG000220519.
PhylomeDBiQ79FE1.

Enzyme and pathway databases

BioCyciMTBRV:RV2430C-MONOMER.

Family and domain databases

InterProiIPR000030. PPE_family.
[Graphical view]
PfamiPF00823. PPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPE41_MYCTU
AccessioniPrimary (citable) accession number: Q79FE1
Secondary accession number(s): F2GHN8, I6YDD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 9, 2015
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.