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Protein

PPE family protein PPE41

Gene

PPE41

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The PE25/PPE41 dimer induces both a strong humoral and cellular immune response (PubMed:18974870). The dimer induces necrosis, but not apoptosis, in mouse macrophage cells (PubMed:25379378). It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses (PubMed:26318856).3 Publications

GO - Biological processi

Keywordsi

Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
PPE family protein PPE41Curated
Gene namesi
Name:PPE41Imported
Ordered Locus Names:Rv2430cImported
ORF Names:LH57_13290Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2430c

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • extracellular region Source: MTBBASE

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi124A → L: Does not disrupt the interaction with EspG5. 1 Publication1
Mutagenesisi125L → E or R: Does not affect formation of the PE25/PPE41 dimer, but abolishes EspG5 binding to PE25/PPE41. 1 Publication1
Mutagenesisi127Q → I: Does not disrupt the interaction with EspG5. 1 Publication1
Mutagenesisi129 – 130TA → DR: Does not affect formation of the PE25/PPE41 dimer, but abolishes EspG5 binding to PE25/PPE41. 1 Publication2
Mutagenesisi130A → I: Does not disrupt the interaction with EspG5. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004351111 – 194PPE family protein PPE41Add BLAST194

Proteomic databases

PaxDbiQ79FE1
PRIDEiQ79FE1

Interactioni

Subunit structurei

Forms a heterodimer with PE25. The dimer forms a 1:1:1 heterotrimeric complex with EspG5. PPE41 interacts directly with EspG5.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-42564N
IntActiQ79FE1, 2 interactors
MINTiQ79FE1
STRINGi83332.Rv2430c

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Helixi8 – 17Combined sources10
Helixi22 – 49Combined sources28
Turni50 – 55Combined sources6
Helixi59 – 67Combined sources9
Helixi69 – 102Combined sources34
Helixi106 – 121Combined sources16
Helixi129 – 162Combined sources34

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G38X-ray2.20B/D1-194[»]
4KXRX-ray2.60B1-194[»]
4W4KX-ray1.95B/D1-174[»]
4W4LX-ray2.45B1-174[»]
ProteinModelPortaliQ79FE1
SMRiQ79FE1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ79FE1

Family & Domainsi

Sequence similaritiesi

Belongs to the mycobacterial PPE family.Curated

Phylogenomic databases

eggNOGiENOG4106EC3 Bacteria
ENOG410ZQNN LUCA
HOGENOMiHOG000220519
PhylomeDBiQ79FE1

Family and domain databases

Gene3Di1.20.1260.20, 1 hit
InterProiView protein in InterPro
IPR000030 PPE_family
IPR038332 PPE_sf
PfamiView protein in Pfam
PF00823 PPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q79FE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFEAYPPEV NSANIYAGPG PDSMLAAARA WRSLDVEMTA VQRSFNRTLL
60 70 80 90 100
SLMDAWAGPV VMQLMEAAKP FVRWLTDLCV QLSEVERQIH EIVRAYEWAH
110 120 130 140 150
HDMVPLAQIY NNRAERQILI DNNALGQFTA QIADLDQEYD DFWDEDGEVM
160 170 180 190
RDYRLRVSDA LSKLTPWKAP PPIAHSTVLV APVSPSTASS RTDT
Length:194
Mass (Da):21,943
Last modified:July 5, 2004 - v1
Checksum:i85F63AA653B04D75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP45222.1
CP009480 Genomic DNA Translation: AIR15197.1
RefSeqiWP_003412549.1, NZ_KK339370.1
YP_177881.1, NC_000962.3

Genome annotation databases

EnsemblBacteriaiAIR15197; AIR15197; LH57_13290
CCP45222; CCP45222; Rv2430c
GeneIDi885945
KEGGimtu:Rv2430c
mtv:RVBD_2430c
PATRICifig|83332.111.peg.2717

Similar proteinsi

Entry informationi

Entry nameiPPE41_MYCTU
AccessioniPrimary (citable) accession number: Q79FE1
Secondary accession number(s): F2GHN8, I6YDD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 9, 2015
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health