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Protein

Sporulenol synthase

Gene

sqhC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cyclization of tetraprenyl beta-curcumene into sporulenol.1 Publication

Catalytic activityi

Sporulenol = tetraprenyl-beta-curcumene + H2O.1 Publication

Pathwayi: hopanoid biosynthesis

This protein is involved in the pathway hopanoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hopanoid biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciBSUB:BSU19320-MONOMER.
UniPathwayiUPA00337.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulenol synthase (EC:4.2.1.137)
Alternative name(s):
Tetraprenyl-beta-curcumene cyclase
Gene namesi
Name:sqhC
Ordered Locus Names:BSU19320
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Sporulenol synthasePRO_0000360070Add
BLAST

Proteomic databases

PaxDbiQ796C3.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010666.

Structurei

3D structure databases

ProteinModelPortaliQ796C3.
SMRiQ796C3. Positions 35-120, 241-294, 316-358, 464-581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati395 – 43642PFTB 1Add
BLAST
Repeati465 – 50541PFTB 2Add
BLAST
Repeati513 – 55442PFTB 3Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 3 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105EWU. Bacteria.
COG1657. LUCA.
HOGENOMiHOG000220823.
InParanoidiQ796C3.
KOiK18115.
OMAiGWAFEFH.
PhylomeDBiQ796C3.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

Sequencei

Sequence statusi: Complete.

Q796C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLQEKVRR FQKKTITELR DRQNADGSWT FCFEGPIMTN SFFILLLTSL
60 70 80 90 100
DEGENEKELI SSLAAGIHAK QQPDGTFINY PDETRGNLTA TVQGYVGMLA
110 120 130 140 150
SGCFHRTEPH MKKAEQFIIS HGGLRHVHFM TKWMLAANGL YPWPALYLPL
160 170 180 190 200
SLMALPPTLP IHFYQFSSYA RIHFAPMAVT LNQRFVLINR NISSLHHLDP
210 220 230 240 250
HMTKNPFTWL RSDAFEERDL TSILLHWKRV FHAPFAFQQL GLQTAKTYML
260 270 280 290 300
DRIEKDGTLY SYASATIYMV YSLLSLGVSR YSPIIRRAIT GIKSLVTKCN
310 320 330 340 350
GIPYLENSTS TVWDTALISY ALQKNGVTET DGSVTKAADF LLERQHTKIA
360 370 380 390 400
DWSVKNPNSV PGGWGFSNIN TNNPDCDDTT AVLKAIPRNH SPAAWERGVS
410 420 430 440 450
WLLSMQNNDG GFSAFEKNVN HPLIRLLPLE SAEDAAVDPS TADLTGRVLH
460 470 480 490 500
FLGEKVGFTE KHQHIQRAVK WLFEHQEQNG SWYGRWGVCY IYGTWAALTG
510 520 530 540 550
MHACGVDRKH PGIQKALRWL KSIQNDDGSW GESCKSAEIK TYVPLHRGTI
560 570 580 590 600
VQTAWALDAL LTYENSEHPS VVKGMQYLTD SSSHSADSLA YPAGIGLPKQ
610 620 630
FYIRYHSYPY VFSLLAVGKY LDSIEKETAN ET
Length:632
Mass (Da):71,224
Last modified:July 5, 2004 - v1
Checksum:iC79E4090386832F6
GO

Sequence cautioni

The sequence AAB84441 differs from that shown. Reason: Frameshift at position 506. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027868 Genomic DNA. Translation: AAB84441.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB13824.2.
PIRiA69718.
RefSeqiNP_389814.2. NC_000964.3.
WP_004399534.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB13824; CAB13824; BSU19320.
GeneIDi939443.
KEGGibsu:BSU19320.
PATRICi18975715. VBIBacSub10457_2048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027868 Genomic DNA. Translation: AAB84441.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB13824.2.
PIRiA69718.
RefSeqiNP_389814.2. NC_000964.3.
WP_004399534.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliQ796C3.
SMRiQ796C3. Positions 35-120, 241-294, 316-358, 464-581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010666.

Proteomic databases

PaxDbiQ796C3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13824; CAB13824; BSU19320.
GeneIDi939443.
KEGGibsu:BSU19320.
PATRICi18975715. VBIBacSub10457_2048.

Phylogenomic databases

eggNOGiENOG4105EWU. Bacteria.
COG1657. LUCA.
HOGENOMiHOG000220823.
InParanoidiQ796C3.
KOiK18115.
OMAiGWAFEFH.
PhylomeDBiQ796C3.

Enzyme and pathway databases

UniPathwayiUPA00337.
BioCyciBSUB:BSU19320-MONOMER.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSQHC_BACSU
AccessioniPrimary (citable) accession number: Q796C3
Secondary accession number(s): O34650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.