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Q795Y4

- FDHL_BACSU

UniProt

Q795Y4 - FDHL_BACSU

Protein

Putative formate dehydrogenase YrhE

Gene

yrhE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 4 4Fe-4S clusters.By similarity
    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi50 – 501Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi53 – 531Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi65 – 651Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi97 – 971Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity
    Metal bindingi101 – 1011Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi104 – 1041Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi111 – 1111Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi156 – 1561Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi159 – 1591Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi163 – 1631Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi199 – 1991Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi202 – 2021Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi206 – 2061Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi270 – 2701Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi273 – 2731Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi277 – 2771Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi305 – 3051Iron-sulfur 5 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. electron carrier activity Source: InterPro
    4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    5. molybdenum ion binding Source: InterPro

    GO - Biological processi

    1. formate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU27220-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative formate dehydrogenase YrhE (EC:1.2.1.2)
    Gene namesi
    Name:yrhE
    Ordered Locus Names:BSU27220
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU27220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 980980Putative formate dehydrogenase YrhEPRO_0000360689Add
    BLAST

    Proteomic databases

    PaxDbiQ795Y4.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU27220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ795Y4.
    SMRiQ795Y4. Positions 5-218, 262-939.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 81772Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 171284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini187 – 216304Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini263 – 319574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni258 – 980723Formate dehydrogenaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG3383.
    HOGENOMiHOG000031440.
    KOiK00123.
    OMAiLDNRSTW.
    OrthoDBiEOG6CVV7G.
    PhylomeDBiQ795Y4.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR012675. Beta-grasp_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view]
    PfamiPF13237. Fer4_10. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036643. FDH_alpha. 1 hit.
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q795Y4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDVKSISVR VDGTEIQARA GATILDILNE NGIEYPQICH VPEVDPIQTC    50
    DTCIVEANGK LVRSCATVAE NGMSIDLSGN RVKEAQTEAM DRLLENHLLY 100
    CTVCDNNNGN CTLHNTAEMM GIEHQKYPYT PKEDPSCAVD MSHPFYRYDP 150
    NQCIACGQCV EVCQNLQVNE TLSIDWERER PRVIWDEGVP INESSCVSCG 200
    QCVTVCPCNA LMEKSMLGQA GFMTGIKEDV MEPMIDLVKN VEPGYGSIFA 250
    ISEVEAAMRE TRTKKTKTVC TFCGVGCSFE VWTKGRDILK IQPVSDAPVN 300
    AISTCVKGKF GWDFVNSKER ITKPLIRKNG AFVESSWEEA LDLVASRLGS 350
    IKEQYGKGSV GFISSSKITN EENYVIQKLA RQVFETNNVD NCSRYCQSPA 400
    TDGLFRTVGM GGDAGTIKDI AKAGLVIIVG ANPAEGHPVL ATRVKRAHKL 450
    HGQKLIVADL RKNEMAERSD LFISPKQGTD QVWLMAVTKY MIDQGWHDQA 500
    FIDENVNYFE DYKETLKTYT LDYAERITGL SKENIIQIAE MIRDADGTCV 550
    LWGMGVTQNT GGSDTSAAIS NLLLATGNYR RPGAGAYPLR GHNNVQGACD 600
    MGTLPGWLPG YQHITDDKAR AKFEEAYGVE IDGKPGLDNI QMLHAIEEGK 650
    MKAMYLVGED MALVDSNANH VHDILSSLDF FVVQDIFLSR TAQYADVVLP 700
    ATPSLEKDGT FTNTERRVQR LYQALPTLGD AKPDWWIIQE VANRLGANWN 750
    YSHPSDIFSE MASLSPLFAK ASYEVLEGWN SFLWGSFTGE STPLLYEDGF 800
    NFPDKKARFA LSDWTEPAAF PEEYDLHINN GRMLEHFHEG NMTNKSKGIQ 850
    AKVPNVFVEI SPELAQERGV CDGSLVRLVS PFGAVKLNAL ITDRVRKNEL 900
    YLPMNSTDKE SAINFLTGPA ADKRTNTPAY KQTKVRMEVL GGCETAPLPK 950
    TNPRNKKRHP QNGVEAERKW NRPGYVHLTD 980
    Length:980
    Mass (Da):108,775
    Last modified:July 5, 2004 - v1
    Checksum:i0DA2B17A506806ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB14664.1.
    RefSeqiNP_390600.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB14664; CAB14664; BSU27220.
    GeneIDi937569.
    KEGGibsu:BSU27220.
    PATRICi18977300. VBIBacSub10457_2839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL009126 Genomic DNA. Translation: CAB14664.1 .
    RefSeqi NP_390600.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali Q795Y4.
    SMRi Q795Y4. Positions 5-218, 262-939.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU27220.

    Proteomic databases

    PaxDbi Q795Y4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14664 ; CAB14664 ; BSU27220 .
    GeneIDi 937569.
    KEGGi bsu:BSU27220.
    PATRICi 18977300. VBIBacSub10457_2839.

    Organism-specific databases

    GenoListi BSU27220.

    Phylogenomic databases

    eggNOGi COG3383.
    HOGENOMi HOG000031440.
    KOi K00123.
    OMAi LDNRSTW.
    OrthoDBi EOG6CVV7G.
    PhylomeDBi Q795Y4.

    Enzyme and pathway databases

    BioCyci BSUB:BSU27220-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR012675. Beta-grasp_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view ]
    Pfami PF13237. Fer4_10. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036643. FDH_alpha. 1 hit.
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiFDHL_BACSU
    AccessioniPrimary (citable) accession number: Q795Y4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3