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Q795Y4

- FDHL_BACSU

UniProt

Q795Y4 - FDHL_BACSU

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Protein

Putative formate dehydrogenase YrhE

Gene

yrhE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi50 – 501Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi53 – 531Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi65 – 651Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi97 – 971Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity
Metal bindingi101 – 1011Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi104 – 1041Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi111 – 1111Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi156 – 1561Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi159 – 1591Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi163 – 1631Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi199 – 1991Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi202 – 2021Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi206 – 2061Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi270 – 2701Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi273 – 2731Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi277 – 2771Iron-sulfur 5 (4Fe-4S)By similarity
Metal bindingi305 – 3051Iron-sulfur 5 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciBSUB:BSU27220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase YrhE (EC:1.2.1.2)
Gene namesi
Name:yrhE
Ordered Locus Names:BSU27220
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU27220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 980980Putative formate dehydrogenase YrhEPRO_0000360689Add
BLAST

Proteomic databases

PaxDbiQ795Y4.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU27220.

Structurei

3D structure databases

ProteinModelPortaliQ795Y4.
SMRiQ795Y4. Positions 5-218, 262-939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 81772Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini144 – 171284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini187 – 216304Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini263 – 319574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni258 – 980723Formate dehydrogenaseBy similarityAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
InParanoidiQ795Y4.
KOiK00123.
OMAiLDNRSTW.
OrthoDBiEOG6CVV7G.
PhylomeDBiQ795Y4.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR012675. Beta-grasp_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF13237. Fer4_10. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q795Y4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDVKSISVR VDGTEIQARA GATILDILNE NGIEYPQICH VPEVDPIQTC
60 70 80 90 100
DTCIVEANGK LVRSCATVAE NGMSIDLSGN RVKEAQTEAM DRLLENHLLY
110 120 130 140 150
CTVCDNNNGN CTLHNTAEMM GIEHQKYPYT PKEDPSCAVD MSHPFYRYDP
160 170 180 190 200
NQCIACGQCV EVCQNLQVNE TLSIDWERER PRVIWDEGVP INESSCVSCG
210 220 230 240 250
QCVTVCPCNA LMEKSMLGQA GFMTGIKEDV MEPMIDLVKN VEPGYGSIFA
260 270 280 290 300
ISEVEAAMRE TRTKKTKTVC TFCGVGCSFE VWTKGRDILK IQPVSDAPVN
310 320 330 340 350
AISTCVKGKF GWDFVNSKER ITKPLIRKNG AFVESSWEEA LDLVASRLGS
360 370 380 390 400
IKEQYGKGSV GFISSSKITN EENYVIQKLA RQVFETNNVD NCSRYCQSPA
410 420 430 440 450
TDGLFRTVGM GGDAGTIKDI AKAGLVIIVG ANPAEGHPVL ATRVKRAHKL
460 470 480 490 500
HGQKLIVADL RKNEMAERSD LFISPKQGTD QVWLMAVTKY MIDQGWHDQA
510 520 530 540 550
FIDENVNYFE DYKETLKTYT LDYAERITGL SKENIIQIAE MIRDADGTCV
560 570 580 590 600
LWGMGVTQNT GGSDTSAAIS NLLLATGNYR RPGAGAYPLR GHNNVQGACD
610 620 630 640 650
MGTLPGWLPG YQHITDDKAR AKFEEAYGVE IDGKPGLDNI QMLHAIEEGK
660 670 680 690 700
MKAMYLVGED MALVDSNANH VHDILSSLDF FVVQDIFLSR TAQYADVVLP
710 720 730 740 750
ATPSLEKDGT FTNTERRVQR LYQALPTLGD AKPDWWIIQE VANRLGANWN
760 770 780 790 800
YSHPSDIFSE MASLSPLFAK ASYEVLEGWN SFLWGSFTGE STPLLYEDGF
810 820 830 840 850
NFPDKKARFA LSDWTEPAAF PEEYDLHINN GRMLEHFHEG NMTNKSKGIQ
860 870 880 890 900
AKVPNVFVEI SPELAQERGV CDGSLVRLVS PFGAVKLNAL ITDRVRKNEL
910 920 930 940 950
YLPMNSTDKE SAINFLTGPA ADKRTNTPAY KQTKVRMEVL GGCETAPLPK
960 970 980
TNPRNKKRHP QNGVEAERKW NRPGYVHLTD
Length:980
Mass (Da):108,775
Last modified:July 5, 2004 - v1
Checksum:i0DA2B17A506806ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB14664.1.
RefSeqiNP_390600.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14664; CAB14664; BSU27220.
GeneIDi937569.
KEGGibsu:BSU27220.
PATRICi18977300. VBIBacSub10457_2839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA. Translation: CAB14664.1 .
RefSeqi NP_390600.1. NC_000964.3.

3D structure databases

ProteinModelPortali Q795Y4.
SMRi Q795Y4. Positions 5-218, 262-939.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU27220.

Proteomic databases

PaxDbi Q795Y4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14664 ; CAB14664 ; BSU27220 .
GeneIDi 937569.
KEGGi bsu:BSU27220.
PATRICi 18977300. VBIBacSub10457_2839.

Organism-specific databases

GenoListi BSU27220.

Phylogenomic databases

eggNOGi COG3383.
HOGENOMi HOG000031440.
InParanoidi Q795Y4.
KOi K00123.
OMAi LDNRSTW.
OrthoDBi EOG6CVV7G.
PhylomeDBi Q795Y4.

Enzyme and pathway databases

BioCyci BSUB:BSU27220-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR012675. Beta-grasp_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF13237. Fer4_10. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036643. FDH_alpha. 1 hit.
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiFDHL_BACSU
AccessioniPrimary (citable) accession number: Q795Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3