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Protein

Putative formate dehydrogenase YrhE

Gene

yrhE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi50Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi53Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi65Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi97Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi101Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi104Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi111Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi153Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi156Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi159Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi163Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi196Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi199Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi202Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi206Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi270Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi273Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi277Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi305Iron-sulfur 5 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciBSUB:BSU27220-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase YrhE (EC:1.17.1.9)
Gene namesi
Name:yrhE
Ordered Locus Names:BSU27220
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003606891 – 980Putative formate dehydrogenase YrhEAdd BLAST980

Proteomic databases

PaxDbiQ795Y4

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014876

Structurei

3D structure databases

ProteinModelPortaliQ795Y4
SMRiQ795Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 812Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST77
Domaini81 – 1214Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST41
Domaini144 – 1714Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini187 – 2164Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
Domaini263 – 3194Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 980Formate dehydrogenaseBy similarityAdd BLAST723

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108JB9 Bacteria
COG3383 LUCA
HOGENOMiHOG000031440
InParanoidiQ795Y4
KOiK00123
OMAiNLAWCHP
PhylomeDBiQ795Y4

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR009010 Asp_de-COase-like_dom_sf
IPR006478 Formate_DH_asu
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01591 Fdh-alpha, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit

Sequencei

Sequence statusi: Complete.

Q795Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDVKSISVR VDGTEIQARA GATILDILNE NGIEYPQICH VPEVDPIQTC
60 70 80 90 100
DTCIVEANGK LVRSCATVAE NGMSIDLSGN RVKEAQTEAM DRLLENHLLY
110 120 130 140 150
CTVCDNNNGN CTLHNTAEMM GIEHQKYPYT PKEDPSCAVD MSHPFYRYDP
160 170 180 190 200
NQCIACGQCV EVCQNLQVNE TLSIDWERER PRVIWDEGVP INESSCVSCG
210 220 230 240 250
QCVTVCPCNA LMEKSMLGQA GFMTGIKEDV MEPMIDLVKN VEPGYGSIFA
260 270 280 290 300
ISEVEAAMRE TRTKKTKTVC TFCGVGCSFE VWTKGRDILK IQPVSDAPVN
310 320 330 340 350
AISTCVKGKF GWDFVNSKER ITKPLIRKNG AFVESSWEEA LDLVASRLGS
360 370 380 390 400
IKEQYGKGSV GFISSSKITN EENYVIQKLA RQVFETNNVD NCSRYCQSPA
410 420 430 440 450
TDGLFRTVGM GGDAGTIKDI AKAGLVIIVG ANPAEGHPVL ATRVKRAHKL
460 470 480 490 500
HGQKLIVADL RKNEMAERSD LFISPKQGTD QVWLMAVTKY MIDQGWHDQA
510 520 530 540 550
FIDENVNYFE DYKETLKTYT LDYAERITGL SKENIIQIAE MIRDADGTCV
560 570 580 590 600
LWGMGVTQNT GGSDTSAAIS NLLLATGNYR RPGAGAYPLR GHNNVQGACD
610 620 630 640 650
MGTLPGWLPG YQHITDDKAR AKFEEAYGVE IDGKPGLDNI QMLHAIEEGK
660 670 680 690 700
MKAMYLVGED MALVDSNANH VHDILSSLDF FVVQDIFLSR TAQYADVVLP
710 720 730 740 750
ATPSLEKDGT FTNTERRVQR LYQALPTLGD AKPDWWIIQE VANRLGANWN
760 770 780 790 800
YSHPSDIFSE MASLSPLFAK ASYEVLEGWN SFLWGSFTGE STPLLYEDGF
810 820 830 840 850
NFPDKKARFA LSDWTEPAAF PEEYDLHINN GRMLEHFHEG NMTNKSKGIQ
860 870 880 890 900
AKVPNVFVEI SPELAQERGV CDGSLVRLVS PFGAVKLNAL ITDRVRKNEL
910 920 930 940 950
YLPMNSTDKE SAINFLTGPA ADKRTNTPAY KQTKVRMEVL GGCETAPLPK
960 970 980
TNPRNKKRHP QNGVEAERKW NRPGYVHLTD
Length:980
Mass (Da):108,775
Last modified:July 5, 2004 - v1
Checksum:i0DA2B17A506806ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB14664.1
RefSeqiNP_390600.1, NC_000964.3
WP_010886582.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14664; CAB14664; BSU27220
GeneIDi937569
KEGGibsu:BSU27220
PATRICifig|224308.43.peg.2839

Similar proteinsi

Entry informationi

Entry nameiFDHL_BACSU
AccessioniPrimary (citable) accession number: Q795Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome