Reviewed, UniProtKB/Swiss-Prot Q793U7 (B3GL1_MUSSI)

Names and origin

Protein names

Recommended name:
    UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
    EC=2.4.1.79
Alternative name(s):
    Beta-3-GalNAc-T1
    Beta-1,3-galactosyltransferase 3
      Short name=Beta-1,3-GalTase 3
      Short name=Beta3Gal-T3
      Short name=b3Gal-T3
    Beta-3-Gx-T3
    Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
    UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
    Globoside synthase

Gene names

Name:	B3galnt1
Synonyms:	B3galt3, B3gt3

Organism

Mus spicilegus (Steppe mouse)

Taxonomic identifier

10103 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transfers N-acetylgalactosamine onto globotriaosylceramide By similarity.
Catalytic activity	UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Cofactor	Magnesium By similarity.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 31 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity Inferred from electronic annotation. Source: EC galactosyltransferase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1		PRO_0000219155
Regions
	Topological domain	1 – 20	20	Cytoplasmic Potential
	Transmembrane	21 – 43	23	Signal-anchor for type II membrane protein Potential
	Topological domain	44 – 331	288	Lumenal Potential
Amino acid modifications
	Modified residue	140	1	Phosphotyrosine By similarity
	Modified residue	152	1	Phosphotyrosine By similarity
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	154	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	326	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q793U7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 387E8B0C75FC282D	FASTA	331	39,371
	10 20 30 40 50 60 MAPAVLTALP NRMSLRSLKW SLLLLSLLSF LVIWYLSLPH YNVIERVNWM YFYEYEPIYR 70 80 90 100 110 120 QDFRFTLREH SNCSHQNPFL VILVTSRPSD VKARQAIRVT WGEKKSWWGY EVLTFFLLGQ 130 140 150 160 170 180 QAEREDKTLA LSLEDEHVLY GDIIRQDFLD TYNNLTLKTI MAFRWVMEFC PNAKYIMKTD 190 200 210 220 230 240 TDVFINTGNL VKYLLNLNHS EKFFTGYPLI DNYSYRGFFH KNHISYQEYP FKVFPPYCSG 250 260 270 280 290 300 LGYIMSGDLV PRVYEMMSHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLYRIHLDVC 310 320 330 QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y

References

[1]	"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies." Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ZBN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB039163 Genomic DNA. Translation: BAB68687.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q793U7.
Enzyme and pathway databases
BRENDA	2.4.1.79. 264955.
Family and domain databases
InterPro	IPR002659. Glyco_trans_31. [Graphical view]
PANTHER	PTHR11214. Glyco_trans_31. 1 hit.
Pfam	PF01762. Galactosyl_T. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B3GL1_MUSSI

Accession

Primary (citable) accession number: Q793U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2004
Last modified:	October 13, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)