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Protein

Bcl-2-related ovarian killer protein

Gene

Bok

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces apoptosis in a manner dependent on BAX and BAK.By similarity

GO - Molecular functioni

  • BH domain binding Source: RGD
  • protein dimerization activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  • apoptotic process Source: UniProtKB
  • brain development Source: RGD
  • cell proliferation Source: Ensembl
  • intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
  • male gonad development Source: RGD
  • neuron apoptotic process Source: Ensembl
  • oligodendrocyte differentiation Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of execution phase of apoptosis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related ovarian killer protein
Gene namesi
Name:Bok
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi70984. Bok.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity
  • Golgi apparatus membrane By similarity; Single-pass membrane protein By similarity

  • Note: The transmembrane domain is necessary and sufficient for Golgi and ER targeting.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Bcl-2-related ovarian killer proteinPRO_0000143088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ792S6.
PRIDEiQ792S6.

PTM databases

PhosphoSiteiQ792S6.

Expressioni

Tissue specificityi

Expressed in ovary, testis and uterus.1 Publication

Gene expression databases

GenevisibleiQ792S6. RN.

Interactioni

GO - Molecular functioni

  • BH domain binding Source: RGD
  • protein dimerization activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024693.

Structurei

3D structure databases

ProteinModelPortaliQ792S6.
SMRiQ792S6. Positions 45-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 4413BH4Add
BLAST
Motifi67 – 8317BH3Add
BLAST
Motifi113 – 13220BH1Add
BLAST
Motifi165 – 17915BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048498.
HOGENOMiHOG000290675.
HOVERGENiHBG050709.
InParanoidiQ792S6.
KOiK02561.
OMAiCRDYIHS.
OrthoDBiEOG7FZ00G.
PhylomeDBiQ792S6.
TreeFamiTF315834.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF48. PTHR11256:SF48. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q792S6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW
60 70 80 90 100
SAPERASPAP GGRLAEVCTV LLRLGDELEQ IRPSVYRNVA RQLHIPLQSE
110 120 130 140 150
PVVTDAFLAV AGHIFSAGIT WGKVVSLYSV AAGLAVDCVR QAQPAMVHAL
160 170 180 190 200
VDCLGEFVRK TLATWLRRRG GWTDVLKCVV STDPGFRSHW LVATLCSFGR
210
FLKAAFFLLL PER
Length:213
Mass (Da):23,456
Last modified:July 5, 2004 - v1
Checksum:iF8755C45CB05D626
GO
Isoform 2 (identifier: Q792S6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-117: Missing.

Show »
Length:170
Mass (Da):18,729
Checksum:i15E54361F448CF16
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 11743Missing in isoform 2. 1 PublicationVSP_012447Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027954 mRNA. Translation: AAB87418.1.
AF051093 mRNA. Translation: AAC61928.1.
BC078871 mRNA. Translation: AAH78871.1.
RefSeqiNP_059008.1. NM_017312.2. [Q792S6-1]
UniGeneiRn.44461.

Genome annotation databases

EnsembliENSRNOT00000024526; ENSRNOP00000024526; ENSRNOG00000018214. [Q792S6-2]
ENSRNOT00000024695; ENSRNOP00000024693; ENSRNOG00000018214. [Q792S6-1]
GeneIDi29884.
KEGGirno:29884.
UCSCiRGD:70984. rat. [Q792S6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027954 mRNA. Translation: AAB87418.1.
AF051093 mRNA. Translation: AAC61928.1.
BC078871 mRNA. Translation: AAH78871.1.
RefSeqiNP_059008.1. NM_017312.2. [Q792S6-1]
UniGeneiRn.44461.

3D structure databases

ProteinModelPortaliQ792S6.
SMRiQ792S6. Positions 45-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024693.

PTM databases

PhosphoSiteiQ792S6.

Proteomic databases

PaxDbiQ792S6.
PRIDEiQ792S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024526; ENSRNOP00000024526; ENSRNOG00000018214. [Q792S6-2]
ENSRNOT00000024695; ENSRNOP00000024693; ENSRNOG00000018214. [Q792S6-1]
GeneIDi29884.
KEGGirno:29884.
UCSCiRGD:70984. rat. [Q792S6-1]

Organism-specific databases

CTDi666.
RGDi70984. Bok.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
GeneTreeiENSGT00510000048498.
HOGENOMiHOG000290675.
HOVERGENiHBG050709.
InParanoidiQ792S6.
KOiK02561.
OMAiCRDYIHS.
OrthoDBiEOG7FZ00G.
PhylomeDBiQ792S6.
TreeFamiTF315834.

Miscellaneous databases

NextBioi610312.
PROiQ792S6.

Gene expression databases

GenevisibleiQ792S6. RN.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF48. PTHR11256:SF48. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members."
    Hsu S.Y., Kaipia A., McGee E., Lomeli M., Hsueh A.J.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:12401-12406(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Ovary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiBOK_RAT
AccessioniPrimary (citable) accession number: Q792S6
Secondary accession number(s): O88857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.