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Protein

Cysteine-rich PDZ-binding protein

Gene

Cript

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • PDZ domain binding Source: RGD
  • protein complex binding Source: RGD

GO - Biological processi

  • cytoplasmic microtubule organization Source: RGD
  • establishment of protein localization Source: RGD
  • protein localization to microtubule Source: UniProtKB
  • regulation of postsynaptic density protein 95 clustering Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich PDZ-binding protein
Alternative name(s):
Cysteine-rich interactor of PDZ three
Short name:
Cysteine-rich interactor of PDZ3
Gene namesi
Name:Cript
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621545. Cript.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • dendrite Source: RGD
  • dendritic shaft Source: RGD
  • dendritic spine Source: RGD
  • neuronal cell body Source: RGD
  • nucleolus Source: Ensembl
  • postsynaptic density Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi98 – 981Q → E: Abolishes interaction with DLG4. Strongly abolishes interaction with DLG4; when associated with D-100. 1 Publication
Mutagenesisi100 – 1001S → D: Abolishes interaction with DLG4. Strongly abolishes interaction with DLG4; when associated with E-98. 1 Publication
Mutagenesisi101 – 1011V → A: Abolishes interaction with DLG4. Does not redistribute DLG4 to microtubules. Associates with microtubules. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Cysteine-rich PDZ-binding proteinPRO_0000314565Add
BLAST

Proteomic databases

PaxDbiQ792Q4.
PRIDEiQ792Q4.

PTM databases

iPTMnetiQ792Q4.
PhosphoSiteiQ792Q4.

Expressioni

Tissue specificityi

Expressed in striatum, cortex, midbrain, Purkinje cells of the cerebellum, pyramidal neurons of the hippocampus and neuropil. Expressed in heart, brain, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000015215.
GenevisibleiQ792Q4. RN.

Interactioni

Subunit structurei

Interacts with DLG4 and TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates with microtubules.1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • PDZ domain binding Source: RGD
  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi248569. 1 interaction.
IntActiQ792Q4. 1 interaction.
STRINGi10116.ENSRNOP00000020534.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 1017Sufficient for interaction with DLG4
Regioni98 – 1014PDZ3-binding

Sequence similaritiesi

Belongs to the CRIPT family.Curated

Phylogenomic databases

eggNOGiKOG3476. Eukaryota.
ENOG4111RAI. LUCA.
GeneTreeiENSGT00390000002260.
HOGENOMiHOG000242625.
HOVERGENiHBG097641.
InParanoidiQ792Q4.
OMAiPNPWRTS.
OrthoDBiEOG091G0YCT.
PhylomeDBiQ792Q4.
TreeFamiTF300144.

Family and domain databases

InterProiIPR019367. PDZ-binding_CRIPT.
[Graphical view]
PfamiPF10235. Cript. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q792Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCEKCEKKL GRVITPDTWK DGARNTTESG GRKLNENKAL TSKKARFDPY
60 70 80 90 100
GKNKFSTCRI CKSSVHQPGS HYCQGCAYKK GICAMCGKKV LDTKNYKQTS

V
Length:101
Mass (Da):11,271
Last modified:July 5, 2004 - v1
Checksum:i161D694AC81BFDCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047384 mRNA. Translation: AAC40102.1.
RefSeqiNP_063972.1. NM_019907.1.
UniGeneiRn.30508.

Genome annotation databases

EnsembliENSRNOT00000020534; ENSRNOP00000020534; ENSRNOG00000015215.
GeneIDi56725.
KEGGirno:56725.
UCSCiRGD:621545. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047384 mRNA. Translation: AAC40102.1.
RefSeqiNP_063972.1. NM_019907.1.
UniGeneiRn.30508.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248569. 1 interaction.
IntActiQ792Q4. 1 interaction.
STRINGi10116.ENSRNOP00000020534.

PTM databases

iPTMnetiQ792Q4.
PhosphoSiteiQ792Q4.

Proteomic databases

PaxDbiQ792Q4.
PRIDEiQ792Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020534; ENSRNOP00000020534; ENSRNOG00000015215.
GeneIDi56725.
KEGGirno:56725.
UCSCiRGD:621545. rat.

Organism-specific databases

CTDi9419.
RGDi621545. Cript.

Phylogenomic databases

eggNOGiKOG3476. Eukaryota.
ENOG4111RAI. LUCA.
GeneTreeiENSGT00390000002260.
HOGENOMiHOG000242625.
HOVERGENiHBG097641.
InParanoidiQ792Q4.
OMAiPNPWRTS.
OrthoDBiEOG091G0YCT.
PhylomeDBiQ792Q4.
TreeFamiTF300144.

Miscellaneous databases

PROiQ792Q4.

Gene expression databases

BgeeiENSRNOG00000015215.
GenevisibleiQ792Q4. RN.

Family and domain databases

InterProiIPR019367. PDZ-binding_CRIPT.
[Graphical view]
PfamiPF10235. Cript. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIPT_RAT
AccessioniPrimary (citable) accession number: Q792Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.