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Protein
Submitted name:

Alpha-4 integrin

Gene

Itga4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-4 integrinImported
Submitted name:
Integrin alpha 4Imported
Submitted name:
Integrin alpha-4Imported
Submitted name:
Integrin alpha-4 subunitImported
Gene namesi
Name:Itga4Imported
ORF Names:mCG_20065Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96603. Itga4.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei976 – 100025HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333UniRule annotationAdd
BLAST
Chaini34 – 1032999UniRule annotationPRO_5006993734Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099718.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini463 – 856394Integrin_alpha2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation
Contains FG-GAP repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPB2. Eukaryota.
ENOG410XTAR. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG004538.
KOiK06483.
OMAiEKQINCE.
OrthoDBiEOG7MSMN4.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 6 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q792F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEARCRPR SRGIALREAV MLLLYFGVPT GHSYNLDPEN ALLYQGPSGT
60 70 80 90 100
LFGYSVVLHS HGSKRWLIVG APTASWLSNA SVVNPGAIYR CGIRKNPNQT
110 120 130 140 150
CEQLQLGSPS GEPCGKTCLE ERDNQWLGVT LSRQPGENGS IVTCGHRWKN
160 170 180 190 200
IFYMKSDNKL PTGICYVMPS DLRTELSKRM APCYKDYTRK FGENFASCQA
210 220 230 240 250
GISSFYTQDL IVMGAPGSSY WTGTVFVYNI TTNQYKAFVD RQNQVKFGSY
260 270 280 290 300
LGYSVGAGHF RSPHTTEVVG GAPQHEQIGK AYIFSIDENE LNIVYEMKGK
310 320 330 340 350
KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGMGAV
360 370 380 390 400
MVEMERVLVG SDKYAARFGE SIANLGDIDN DGFEDIAIGA PQEDDLRGAV
410 420 430 440 450
YIYNGRVDGI SSTYSQRIEG QQISKSLRMF GQSISGQIDA DNNGYVDVAV
460 470 480 490 500
GAFQSDSAVL LRTRPVVIVE ASLSHPESVN RTKFDCTENG LPSVCMHLTL
510 520 530 540 550
CFSYKGKEVP GYIVLFYNVS LDVHRKAESP SRFYFFSNGT SDVITGSIRV
560 570 580 590 600
SSSGEKCRTH QAFMRKDVRD ILTPIHVEAT YHLGHHVITK RNTEEFPPLQ
610 620 630 640 650
PILQQKKEKD VIRKMINFAR FCAYENCSAD LQVSAKVGFL KPYENKTYLA
660 670 680 690 700
VGSMKTIMLN VSLFNAGDDA YETTLNVQLP TGLYFIKILD LEEKQINCEV
710 720 730 740 750
TESSGIVKLA CSLGYIYVDR LSRIDISFLL DVSSLSRAHE DLSISVHASC
760 770 780 790 800
ENEGELDQVR DNRVTLTIPL RYEVMLTVHG LVNPTSFVYG SSEENEPETC
810 820 830 840 850
MAEKLNLTFH VINTGISMAP NVSVKIMVPN SFLPQDDKLF NVLDVQTTTG
860 870 880 890 900
QCHFKHYGRE CTFAQQKGIA GTLTDIVKFL SKTDKRLLYC MKADQHCLDF
910 920 930 940 950
LCNFGKMESG KEASVHIQLE GRPSILEMDE TSSLKFEIKA TAFPEPHPKV
960 970 980 990 1000
IELNKDENVA HVFLEGLHHQ RPKRHFTIII ITISLLLGLI VLLLISCVMW
1010 1020 1030
KAGFFKRQYK SILQEENRRD SWSYVNSKSN DD
Length:1,032
Mass (Da):115,086
Last modified:July 5, 2004 - v1
Checksum:i6E99ED8B589EF060
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844590 Genomic DNA. No translation available.
U34800
, U34627, U34628, U34629, U34630, U34631, U34632, U34633, U34634, U34635, U34763, U34764, U34765, U34766, U34767, U34768, U34769, U34770, U34797, U34798, U34799 Genomic DNA. Translation: AAB09630.1.
AF109136 mRNA. Translation: AAC95388.1.
CH466519 Genomic DNA. Translation: EDL27240.1.
RefSeqiNP_034706.3. NM_010576.3.
UniGeneiMm.31903.

Genome annotation databases

EnsembliENSMUST00000099972; ENSMUSP00000099718; ENSMUSG00000027009.
GeneIDi16401.
KEGGimmu:16401.
UCSCiuc008kgr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844590 Genomic DNA. No translation available.
U34800
, U34627, U34628, U34629, U34630, U34631, U34632, U34633, U34634, U34635, U34763, U34764, U34765, U34766, U34767, U34768, U34769, U34770, U34797, U34798, U34799 Genomic DNA. Translation: AAB09630.1.
AF109136 mRNA. Translation: AAC95388.1.
CH466519 Genomic DNA. Translation: EDL27240.1.
RefSeqiNP_034706.3. NM_010576.3.
UniGeneiMm.31903.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099972; ENSMUSP00000099718; ENSMUSG00000027009.
GeneIDi16401.
KEGGimmu:16401.
UCSCiuc008kgr.1. mouse.

Organism-specific databases

CTDi3676.
MGIiMGI:96603. Itga4.

Phylogenomic databases

eggNOGiENOG410IPB2. Eukaryota.
ENOG410XTAR. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG004538.
KOiK06483.
OMAiEKQINCE.
OrthoDBiEOG7MSMN4.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSiItga4. mouse.
NextBioi289557.
SOURCEiSearch...

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 6 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the promoter region of the murine alpha-4 integrin subunit."
    De Meirsman C., Schollen E., Jaspers M., Ongena K., Matthijs G., Marynen P., Cassiman J.J.
    DNA Cell Biol. 13:743-754(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  2. "The genomic structure of the murine alpha 4 integrin gene."
    De Meirsman C., Jaspers M., Schollen E., Cassiman J.J.
    DNA Cell Biol. 15:595-603(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  3. Hasegawa M., Foote S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: LiverImported.
  4. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ792F9_MOUSE
AccessioniPrimary (citable) accession number: Q792F9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.