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Q791V5

- MTCH2_MOUSE

UniProt

Q791V5 - MTCH2_MOUSE

Protein

Mitochondrial carrier homolog 2

Gene

Mtch2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The substrate transported is not yet known. Induces mitochondrial depolarization By similarity.By similarity

    GO - Biological processi

    1. hepatocyte apoptotic process Source: MGI
    2. protein localization to mitochondrion Source: MGI
    3. regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGI

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial carrier homolog 2
    Gene namesi
    Name:Mtch2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1929260. Mtch2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrial outer membrane Source: MGI
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 303302Mitochondrial carrier homolog 2PRO_0000090638Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ791V5.
    PaxDbiQ791V5.
    PRIDEiQ791V5.

    PTM databases

    PhosphoSiteiQ791V5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ791V5.
    BgeeiQ791V5.
    CleanExiMM_MTCH2.
    GenevestigatoriQ791V5.

    Interactioni

    Protein-protein interaction databases

    BioGridi207972. 2 interactions.
    IntActiQ791V5. 4 interactions.
    MINTiMINT-1842785.
    STRINGi10090.ENSMUSP00000107095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ791V5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2 – 9897Solcar 1Add
    BLAST
    Repeati118 – 20689Solcar 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311439.
    GeneTreeiENSGT00390000000020.
    HOGENOMiHOG000231394.
    HOVERGENiHBG058632.
    KOiK17885.
    OrthoDBiEOG7966H6.
    PhylomeDBiQ791V5.
    TreeFamiTF313721.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q791V5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ    50
    LPGLFCYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQYYQESEK 100
    PEELGSVTVQ KEYSSSFDRV IKETTREMIA RSAATLITHP FHVITLRSMV 150
    QFIGRESKYC GLCDSIVTIY REEGIVGFFA GLIPRLLGDI ISLWLCNSLA 200
    YLINTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG 250
    LAGGSPPYSP IYTSWIDCWC MLQKAGNMSR GNSLFFRKVP CGKTYCYDLR 300
    MLI 303
    Length:303
    Mass (Da):33,499
    Last modified:July 5, 2004 - v1
    Checksum:i248F8A1E4CF29975
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2061Y → C in BAB27839. (PubMed:16141072)Curated
    Sequence conflicti207 – 2071A → T in BAB25848. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176009 mRNA. Translation: AAD52647.1.
    AK003100 mRNA. Translation: BAB22565.1.
    AK008487 mRNA. Translation: BAB25694.1.
    AK008712 mRNA. Translation: BAB25848.1.
    AK011785 mRNA. Translation: BAB27839.1.
    AK011874 mRNA. Translation: BAB27892.1.
    AK075890 mRNA. Translation: BAC36033.1.
    AK161441 mRNA. Translation: BAE36399.1.
    AK164169 mRNA. Translation: BAE37660.1.
    BC002152 mRNA. Translation: AAH02152.1.
    BC038899 mRNA. Translation: AAH38899.1.
    BC038916 mRNA. Translation: AAH38916.1.
    CCDSiCCDS16416.1.
    RefSeqiNP_062732.1. NM_019758.2.
    UniGeneiMm.28023.

    Genome annotation databases

    EnsembliENSMUST00000136872; ENSMUSP00000121851; ENSMUSG00000027282.
    GeneIDi56428.
    KEGGimmu:56428.
    UCSCiuc008ktn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176009 mRNA. Translation: AAD52647.1 .
    AK003100 mRNA. Translation: BAB22565.1 .
    AK008487 mRNA. Translation: BAB25694.1 .
    AK008712 mRNA. Translation: BAB25848.1 .
    AK011785 mRNA. Translation: BAB27839.1 .
    AK011874 mRNA. Translation: BAB27892.1 .
    AK075890 mRNA. Translation: BAC36033.1 .
    AK161441 mRNA. Translation: BAE36399.1 .
    AK164169 mRNA. Translation: BAE37660.1 .
    BC002152 mRNA. Translation: AAH02152.1 .
    BC038899 mRNA. Translation: AAH38899.1 .
    BC038916 mRNA. Translation: AAH38916.1 .
    CCDSi CCDS16416.1.
    RefSeqi NP_062732.1. NM_019758.2.
    UniGenei Mm.28023.

    3D structure databases

    ProteinModelPortali Q791V5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207972. 2 interactions.
    IntActi Q791V5. 4 interactions.
    MINTi MINT-1842785.
    STRINGi 10090.ENSMUSP00000107095.

    PTM databases

    PhosphoSitei Q791V5.

    Proteomic databases

    MaxQBi Q791V5.
    PaxDbi Q791V5.
    PRIDEi Q791V5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000136872 ; ENSMUSP00000121851 ; ENSMUSG00000027282 .
    GeneIDi 56428.
    KEGGi mmu:56428.
    UCSCi uc008ktn.1. mouse.

    Organism-specific databases

    CTDi 23788.
    MGIi MGI:1929260. Mtch2.

    Phylogenomic databases

    eggNOGi NOG311439.
    GeneTreei ENSGT00390000000020.
    HOGENOMi HOG000231394.
    HOVERGENi HBG058632.
    KOi K17885.
    OrthoDBi EOG7966H6.
    PhylomeDBi Q791V5.
    TreeFami TF313721.

    Miscellaneous databases

    NextBioi 312594.
    PROi Q791V5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q791V5.
    Bgeei Q791V5.
    CleanExi MM_MTCH2.
    Genevestigatori Q791V5.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of an evolutionary conserved mitochondrial carrier family from various organisms."
      Jang J.S., Hahn Y., Park C., Chung J.H.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart, Hippocampus, Small intestine, Stomach, Testis and Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 69-77; 91-119 AND 172-185, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiMTCH2_MOUSE
    AccessioniPrimary (citable) accession number: Q791V5
    Secondary accession number(s): Q3TPS5
    , Q99LZ6, Q9D060, Q9D7Y2, Q9QZP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3