Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial carrier homolog 2

Gene

Mtch2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity).By similarity

GO - Biological processi

  • cellular response to radiation Source: MGI
  • establishment of protein localization to mitochondrial membrane involved in mitochondrial fission Source: MGI
  • hematopoietic stem cell homeostasis Source: MGI
  • hematopoietic stem cell migration Source: MGI
  • hepatocyte apoptotic process Source: MGI
  • lactate metabolic process Source: MGI
  • mitochondrial ATP synthesis coupled electron transport Source: MGI
  • negative regulation of glycolytic process Source: MGI
  • negative regulation of mitochondrial membrane potential Source: MGI
  • positive regulation of apoptotic process Source: GO_Central
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • protein localization to mitochondrion Source: MGI
  • regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 2
Gene namesi
Name:Mtch2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929260. Mtch2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrial outer membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906382 – 303Mitochondrial carrier homolog 2Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ791V5.
MaxQBiQ791V5.
PaxDbiQ791V5.
PRIDEiQ791V5.

PTM databases

iPTMnetiQ791V5.
PhosphoSitePlusiQ791V5.
SwissPalmiQ791V5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027282.
CleanExiMM_MTCH2.
ExpressionAtlasiQ791V5. baseline and differential.
GenevisibleiQ791V5. MM.

Interactioni

Protein-protein interaction databases

BioGridi207972. 2 interactors.
IntActiQ791V5. 4 interactors.
MINTiMINT-1842785.
STRINGi10090.ENSMUSP00000121851.

Structurei

3D structure databases

ProteinModelPortaliQ791V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 98Solcar 1Add BLAST97
Repeati118 – 206Solcar 2Add BLAST89

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2745. Eukaryota.
ENOG410XSXF. LUCA.
GeneTreeiENSGT00390000000020.
HOGENOMiHOG000231394.
HOVERGENiHBG058632.
InParanoidiQ791V5.
KOiK17885.
PhylomeDBiQ791V5.
TreeFamiTF313721.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q791V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ
60 70 80 90 100
LPGLFCYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQYYQESEK
110 120 130 140 150
PEELGSVTVQ KEYSSSFDRV IKETTREMIA RSAATLITHP FHVITLRSMV
160 170 180 190 200
QFIGRESKYC GLCDSIVTIY REEGIVGFFA GLIPRLLGDI ISLWLCNSLA
210 220 230 240 250
YLINTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG
260 270 280 290 300
LAGGSPPYSP IYTSWIDCWC MLQKAGNMSR GNSLFFRKVP CGKTYCYDLR

MLI
Length:303
Mass (Da):33,499
Last modified:July 5, 2004 - v1
Checksum:i248F8A1E4CF29975
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206Y → C in BAB27839 (PubMed:16141072).Curated1
Sequence conflicti207A → T in BAB25848 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176009 mRNA. Translation: AAD52647.1.
AK003100 mRNA. Translation: BAB22565.1.
AK008487 mRNA. Translation: BAB25694.1.
AK008712 mRNA. Translation: BAB25848.1.
AK011785 mRNA. Translation: BAB27839.1.
AK011874 mRNA. Translation: BAB27892.1.
AK075890 mRNA. Translation: BAC36033.1.
AK161441 mRNA. Translation: BAE36399.1.
AK164169 mRNA. Translation: BAE37660.1.
BC002152 mRNA. Translation: AAH02152.1.
BC038899 mRNA. Translation: AAH38899.1.
BC038916 mRNA. Translation: AAH38916.1.
CCDSiCCDS16416.1.
RefSeqiNP_001304170.1. NM_001317241.1.
NP_001304171.1. NM_001317242.1.
NP_001304172.1. NM_001317243.1.
NP_001304173.1. NM_001317244.1.
NP_062732.1. NM_019758.3.
UniGeneiMm.28023.

Genome annotation databases

EnsembliENSMUST00000136872; ENSMUSP00000121851; ENSMUSG00000027282.
GeneIDi56428.
KEGGimmu:56428.
UCSCiuc008ktn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176009 mRNA. Translation: AAD52647.1.
AK003100 mRNA. Translation: BAB22565.1.
AK008487 mRNA. Translation: BAB25694.1.
AK008712 mRNA. Translation: BAB25848.1.
AK011785 mRNA. Translation: BAB27839.1.
AK011874 mRNA. Translation: BAB27892.1.
AK075890 mRNA. Translation: BAC36033.1.
AK161441 mRNA. Translation: BAE36399.1.
AK164169 mRNA. Translation: BAE37660.1.
BC002152 mRNA. Translation: AAH02152.1.
BC038899 mRNA. Translation: AAH38899.1.
BC038916 mRNA. Translation: AAH38916.1.
CCDSiCCDS16416.1.
RefSeqiNP_001304170.1. NM_001317241.1.
NP_001304171.1. NM_001317242.1.
NP_001304172.1. NM_001317243.1.
NP_001304173.1. NM_001317244.1.
NP_062732.1. NM_019758.3.
UniGeneiMm.28023.

3D structure databases

ProteinModelPortaliQ791V5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207972. 2 interactors.
IntActiQ791V5. 4 interactors.
MINTiMINT-1842785.
STRINGi10090.ENSMUSP00000121851.

PTM databases

iPTMnetiQ791V5.
PhosphoSitePlusiQ791V5.
SwissPalmiQ791V5.

Proteomic databases

EPDiQ791V5.
MaxQBiQ791V5.
PaxDbiQ791V5.
PRIDEiQ791V5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000136872; ENSMUSP00000121851; ENSMUSG00000027282.
GeneIDi56428.
KEGGimmu:56428.
UCSCiuc008ktn.1. mouse.

Organism-specific databases

CTDi23788.
MGIiMGI:1929260. Mtch2.

Phylogenomic databases

eggNOGiKOG2745. Eukaryota.
ENOG410XSXF. LUCA.
GeneTreeiENSGT00390000000020.
HOGENOMiHOG000231394.
HOVERGENiHBG058632.
InParanoidiQ791V5.
KOiK17885.
PhylomeDBiQ791V5.
TreeFamiTF313721.

Miscellaneous databases

PROiQ791V5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027282.
CleanExiMM_MTCH2.
ExpressionAtlasiQ791V5. baseline and differential.
GenevisibleiQ791V5. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTCH2_MOUSE
AccessioniPrimary (citable) accession number: Q791V5
Secondary accession number(s): Q3TPS5
, Q99LZ6, Q9D060, Q9D7Y2, Q9QZP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.