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Q791T5 (MTCH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial carrier homolog 1
Alternative name(s):
Mitochondrial carrier-like protein 1
Gene names
Name:Mtch1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential mitochondrial transporter. May play a role in apoptosis By similarity.

Subunit structure

Interacts with PSEN1 By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 2 Solcar repeats.

Sequence caution

The sequence AAH23135.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH26436.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH27274.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE32313.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q791T5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q791T5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     286-302: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Mitochondrial carrier homolog 1
PRO_0000232386

Regions

Transmembrane248 – 26821Helical; Potential
Transmembrane315 – 33521Helical; Potential
Repeat81 – 17696Solcar 1
Repeat192 – 28089Solcar 2

Natural variations

Alternative sequence286 – 30217Missing in isoform 2.
VSP_017883

Experimental info

Sequence conflict101P → A in BAE32313. Ref.3
Sequence conflict461A → G in BAE32313. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CCD3B23B6DF3CB02

FASTA38941,565
        10         20         30         40         50         60 
MGASDPEVAP WAPGGAAGMA GAGAGAGARG GAPAGVEARA RDPPPAHRAH PRHPRPAAQP 

        70         80         90        100        110        120 
SARRMDGGPG APGSGDNAPT TEALFVALGA GVTALSHPLL YVKLLIQVGH EPMPPTLGTN 

       130        140        150        160        170        180 
VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR GLSPRLMSNA LSTVTRGSMK KVFPPDEMEQ 

       190        200        210        220        230        240 
VSNKDDMKTS LKKVVKETSY EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI 

       250        260        270        280        290        300 
GKIFKEEGLL GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG 

       310        320        330        340        350        360 
SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLRAGLPPYS PVFKSWIHCW 

       370        380 
KYLSVQGQLF RGSSLLFRRV SSGSCFALE 

« Hide

Isoform 2 [UniParc].

Checksum: 8A432D696F328640
Show »

FASTA37239,941

References

« Hide 'large scale' references
[1]"Evolutionarily conserved mitochondrial carrier gene family in mouse, human, and zebrafish."
Jang J.S., Hahn Y., Park C., Chung J.H.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
[2]"Genomic sequence analysis in the mouse T-complex region."
Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-389 (ISOFORM 2).
Strain: NOD.
Tissue: Thymus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-389 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-389 (ISOFORM 2).
Strain: FVB/N.
Tissue: Kidney and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040292 Genomic DNA. Translation: BAA92860.1.
AB040292 Genomic DNA. Translation: BAA92861.1.
AF176007 mRNA. Translation: AAD52645.2.
AF192558 mRNA. Translation: AAF12792.2.
AY301264 Genomic DNA. Translation: AAP45196.1.
AY301264 Genomic DNA. Translation: AAP45202.1.
AK154010 mRNA. Translation: BAE32313.1. Different initiation.
BC023135 mRNA. Translation: AAH23135.1. Different initiation.
BC026436 mRNA. Translation: AAH26436.1. Different initiation.
BC027274 mRNA. Translation: AAH27274.1. Different initiation.
RefSeqNP_063933.1. NM_019880.3.
XP_006524731.1. XM_006524668.1.
XP_006524732.1. XM_006524669.1.
XP_006524733.1. XM_006524670.1.
UniGeneMm.285322.
Mm.486273.

3D structure databases

ProteinModelPortalQ791T5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ791T5. 1 interaction.
STRING10090.ENSMUSP00000093077.

PTM databases

PhosphoSiteQ791T5.

Proteomic databases

PaxDbQ791T5.
PRIDEQ791T5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095427; ENSMUSP00000093077; ENSMUSG00000024012. [Q791T5-1]
ENSMUST00000118366; ENSMUSP00000113021; ENSMUSG00000024012. [Q791T5-2]
GeneID56462.
KEGGmmu:56462.
UCSCuc008bst.1. mouse. [Q791T5-1]
uc008bsu.1. mouse. [Q791T5-2]

Organism-specific databases

CTD23787.
MGIMGI:1929261. Mtch1.

Phylogenomic databases

eggNOGNOG311439.
GeneTreeENSGT00390000000020.
HOVERGENHBG058632.
InParanoidQ791T5.
KOK17885.
OMAFTYARHI.
OrthoDBEOG7966H6.
TreeFamTF313721.

Gene expression databases

ArrayExpressQ791T5.
BgeeQ791T5.
CleanExMM_MTCH1.
GenevestigatorQ791T5.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio312714.
PROQ791T5.
SOURCESearch...

Entry information

Entry nameMTCH1_MOUSE
AccessionPrimary (citable) accession number: Q791T5
Secondary accession number(s): Q3U4W7 expand/collapse secondary AC list , Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot