Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q791T5

- MTCH1_MOUSE

UniProt

Q791T5 - MTCH1_MOUSE

Protein

Mitochondrial carrier homolog 1

Gene

Mtch1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Potential mitochondrial transporter. May play a role in apoptosis By similarity.By similarity

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    2. positive regulation of apoptotic process Source: UniProtKB
    3. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial carrier homolog 1
    Alternative name(s):
    Mitochondrial carrier-like protein 1
    Gene namesi
    Name:Mtch1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1929261. Mtch1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Mitochondrial carrier homolog 1PRO_0000232386Add
    BLAST

    Proteomic databases

    MaxQBiQ791T5.
    PaxDbiQ791T5.
    PRIDEiQ791T5.

    PTM databases

    PhosphoSiteiQ791T5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ791T5.
    BgeeiQ791T5.
    CleanExiMM_MTCH1.
    GenevestigatoriQ791T5.

    Interactioni

    Subunit structurei

    Interacts with PSEN1.By similarity

    Protein-protein interaction databases

    IntActiQ791T5. 1 interaction.
    STRINGi10090.ENSMUSP00000093077.

    Structurei

    3D structure databases

    ProteinModelPortaliQ791T5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei248 – 26821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati81 – 17696Solcar 1Add
    BLAST
    Repeati192 – 28089Solcar 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311439.
    GeneTreeiENSGT00390000000020.
    HOVERGENiHBG058632.
    InParanoidiQ791T5.
    KOiK17885.
    OMAiFTYARHI.
    OrthoDBiEOG7966H6.
    PhylomeDBiQ791T5.
    TreeFamiTF313721.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q791T5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGASDPEVAP WAPGGAAGMA GAGAGAGARG GAPAGVEARA RDPPPAHRAH    50
    PRHPRPAAQP SARRMDGGPG APGSGDNAPT TEALFVALGA GVTALSHPLL 100
    YVKLLIQVGH EPMPPTLGTN VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR 150
    GLSPRLMSNA LSTVTRGSMK KVFPPDEMEQ VSNKDDMKTS LKKVVKETSY 200
    EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI GKIFKEEGLL 250
    GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG 300
    SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLRAGLPPYS 350
    PVFKSWIHCW KYLSVQGQLF RGSSLLFRRV SSGSCFALE 389
    Length:389
    Mass (Da):41,565
    Last modified:July 5, 2004 - v1
    Checksum:iCCD3B23B6DF3CB02
    GO
    Isoform 2 (identifier: Q791T5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         286-302: Missing.

    Show »
    Length:372
    Mass (Da):39,941
    Checksum:i8A432D696F328640
    GO

    Sequence cautioni

    The sequence AAH23135.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH26436.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH27274.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE32313.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101P → A in BAE32313. (PubMed:16141072)Curated
    Sequence conflicti46 – 461A → G in BAE32313. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei286 – 30217Missing in isoform 2. 3 PublicationsVSP_017883Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040292 Genomic DNA. Translation: BAA92860.1.
    AB040292 Genomic DNA. Translation: BAA92861.1.
    AF176007 mRNA. Translation: AAD52645.2.
    AF192558 mRNA. Translation: AAF12792.2.
    AY301264 Genomic DNA. Translation: AAP45196.1.
    AY301264 Genomic DNA. Translation: AAP45202.1.
    AK154010 mRNA. Translation: BAE32313.1. Different initiation.
    BC023135 mRNA. Translation: AAH23135.1. Different initiation.
    BC026436 mRNA. Translation: AAH26436.1. Different initiation.
    BC027274 mRNA. Translation: AAH27274.1. Different initiation.
    CCDSiCCDS28596.1. [Q791T5-1]
    RefSeqiNP_063933.1. NM_019880.3. [Q791T5-1]
    XP_006524731.1. XM_006524668.1. [Q791T5-1]
    XP_006524732.1. XM_006524669.1. [Q791T5-2]
    XP_006524733.1. XM_006524670.1. [Q791T5-2]
    UniGeneiMm.285322.
    Mm.486273.

    Genome annotation databases

    EnsembliENSMUST00000095427; ENSMUSP00000093077; ENSMUSG00000024012. [Q791T5-1]
    ENSMUST00000118366; ENSMUSP00000113021; ENSMUSG00000024012. [Q791T5-2]
    GeneIDi56462.
    KEGGimmu:56462.
    UCSCiuc008bst.1. mouse. [Q791T5-1]
    uc008bsu.1. mouse. [Q791T5-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040292 Genomic DNA. Translation: BAA92860.1 .
    AB040292 Genomic DNA. Translation: BAA92861.1 .
    AF176007 mRNA. Translation: AAD52645.2 .
    AF192558 mRNA. Translation: AAF12792.2 .
    AY301264 Genomic DNA. Translation: AAP45196.1 .
    AY301264 Genomic DNA. Translation: AAP45202.1 .
    AK154010 mRNA. Translation: BAE32313.1 . Different initiation.
    BC023135 mRNA. Translation: AAH23135.1 . Different initiation.
    BC026436 mRNA. Translation: AAH26436.1 . Different initiation.
    BC027274 mRNA. Translation: AAH27274.1 . Different initiation.
    CCDSi CCDS28596.1. [Q791T5-1 ]
    RefSeqi NP_063933.1. NM_019880.3. [Q791T5-1 ]
    XP_006524731.1. XM_006524668.1. [Q791T5-1 ]
    XP_006524732.1. XM_006524669.1. [Q791T5-2 ]
    XP_006524733.1. XM_006524670.1. [Q791T5-2 ]
    UniGenei Mm.285322.
    Mm.486273.

    3D structure databases

    ProteinModelPortali Q791T5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q791T5. 1 interaction.
    STRINGi 10090.ENSMUSP00000093077.

    PTM databases

    PhosphoSitei Q791T5.

    Proteomic databases

    MaxQBi Q791T5.
    PaxDbi Q791T5.
    PRIDEi Q791T5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095427 ; ENSMUSP00000093077 ; ENSMUSG00000024012 . [Q791T5-1 ]
    ENSMUST00000118366 ; ENSMUSP00000113021 ; ENSMUSG00000024012 . [Q791T5-2 ]
    GeneIDi 56462.
    KEGGi mmu:56462.
    UCSCi uc008bst.1. mouse. [Q791T5-1 ]
    uc008bsu.1. mouse. [Q791T5-2 ]

    Organism-specific databases

    CTDi 23787.
    MGIi MGI:1929261. Mtch1.

    Phylogenomic databases

    eggNOGi NOG311439.
    GeneTreei ENSGT00390000000020.
    HOVERGENi HBG058632.
    InParanoidi Q791T5.
    KOi K17885.
    OMAi FTYARHI.
    OrthoDBi EOG7966H6.
    PhylomeDBi Q791T5.
    TreeFami TF313721.

    Miscellaneous databases

    NextBioi 312714.
    PROi Q791T5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q791T5.
    Bgeei Q791T5.
    CleanExi MM_MTCH1.
    Genevestigatori Q791T5.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionarily conserved mitochondrial carrier gene family in mouse, human, and zebrafish."
      Jang J.S., Hahn Y., Park C., Chung J.H.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
    2. "Genomic sequence analysis in the mouse T-complex region."
      Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-389 (ISOFORM 2).
      Strain: NOD.
      Tissue: Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-389 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-389 (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Kidney and Mammary gland.

    Entry informationi

    Entry nameiMTCH1_MOUSE
    AccessioniPrimary (citable) accession number: Q791T5
    Secondary accession number(s): Q3U4W7
    , Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3