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Q791T5

- MTCH1_MOUSE

UniProt

Q791T5 - MTCH1_MOUSE

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Protein

Mitochondrial carrier homolog 1

Gene
Mtch1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential mitochondrial transporter. May play a role in apoptosis By similarity.

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  2. positive regulation of apoptotic process Source: UniProtKB
  3. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 1
Alternative name(s):
Mitochondrial carrier-like protein 1
Gene namesi
Name:Mtch1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1929261. Mtch1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei248 – 26821Helical; Reviewed predictionAdd
BLAST
Transmembranei315 – 33521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Mitochondrial carrier homolog 1PRO_0000232386Add
BLAST

Proteomic databases

MaxQBiQ791T5.
PaxDbiQ791T5.
PRIDEiQ791T5.

PTM databases

PhosphoSiteiQ791T5.

Expressioni

Gene expression databases

ArrayExpressiQ791T5.
BgeeiQ791T5.
CleanExiMM_MTCH1.
GenevestigatoriQ791T5.

Interactioni

Subunit structurei

Interacts with PSEN1 By similarity.

Protein-protein interaction databases

IntActiQ791T5. 1 interaction.
STRINGi10090.ENSMUSP00000093077.

Structurei

3D structure databases

ProteinModelPortaliQ791T5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati81 – 17696Solcar 1Add
BLAST
Repeati192 – 28089Solcar 2Add
BLAST

Sequence similaritiesi

Contains 2 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311439.
GeneTreeiENSGT00390000000020.
HOVERGENiHBG058632.
InParanoidiQ791T5.
KOiK17885.
OMAiFTYARHI.
OrthoDBiEOG7966H6.
PhylomeDBiQ791T5.
TreeFamiTF313721.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q791T5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGASDPEVAP WAPGGAAGMA GAGAGAGARG GAPAGVEARA RDPPPAHRAH    50
PRHPRPAAQP SARRMDGGPG APGSGDNAPT TEALFVALGA GVTALSHPLL 100
YVKLLIQVGH EPMPPTLGTN VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR 150
GLSPRLMSNA LSTVTRGSMK KVFPPDEMEQ VSNKDDMKTS LKKVVKETSY 200
EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI GKIFKEEGLL 250
GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG 300
SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLRAGLPPYS 350
PVFKSWIHCW KYLSVQGQLF RGSSLLFRRV SSGSCFALE 389
Length:389
Mass (Da):41,565
Last modified:July 5, 2004 - v1
Checksum:iCCD3B23B6DF3CB02
GO
Isoform 2 (identifier: Q791T5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-302: Missing.

Show »
Length:372
Mass (Da):39,941
Checksum:i8A432D696F328640
GO

Sequence cautioni

The sequence AAH23135.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH26436.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH27274.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE32313.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei286 – 30217Missing in isoform 2. VSP_017883Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101P → A in BAE32313. 1 Publication
Sequence conflicti46 – 461A → G in BAE32313. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040292 Genomic DNA. Translation: BAA92860.1.
AB040292 Genomic DNA. Translation: BAA92861.1.
AF176007 mRNA. Translation: AAD52645.2.
AF192558 mRNA. Translation: AAF12792.2.
AY301264 Genomic DNA. Translation: AAP45196.1.
AY301264 Genomic DNA. Translation: AAP45202.1.
AK154010 mRNA. Translation: BAE32313.1. Different initiation.
BC023135 mRNA. Translation: AAH23135.1. Different initiation.
BC026436 mRNA. Translation: AAH26436.1. Different initiation.
BC027274 mRNA. Translation: AAH27274.1. Different initiation.
CCDSiCCDS28596.1. [Q791T5-1]
RefSeqiNP_063933.1. NM_019880.3. [Q791T5-1]
XP_006524731.1. XM_006524668.1. [Q791T5-1]
XP_006524732.1. XM_006524669.1. [Q791T5-2]
XP_006524733.1. XM_006524670.1. [Q791T5-2]
UniGeneiMm.285322.
Mm.486273.

Genome annotation databases

EnsembliENSMUST00000095427; ENSMUSP00000093077; ENSMUSG00000024012. [Q791T5-1]
ENSMUST00000118366; ENSMUSP00000113021; ENSMUSG00000024012. [Q791T5-2]
GeneIDi56462.
KEGGimmu:56462.
UCSCiuc008bst.1. mouse. [Q791T5-1]
uc008bsu.1. mouse. [Q791T5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040292 Genomic DNA. Translation: BAA92860.1 .
AB040292 Genomic DNA. Translation: BAA92861.1 .
AF176007 mRNA. Translation: AAD52645.2 .
AF192558 mRNA. Translation: AAF12792.2 .
AY301264 Genomic DNA. Translation: AAP45196.1 .
AY301264 Genomic DNA. Translation: AAP45202.1 .
AK154010 mRNA. Translation: BAE32313.1 . Different initiation.
BC023135 mRNA. Translation: AAH23135.1 . Different initiation.
BC026436 mRNA. Translation: AAH26436.1 . Different initiation.
BC027274 mRNA. Translation: AAH27274.1 . Different initiation.
CCDSi CCDS28596.1. [Q791T5-1 ]
RefSeqi NP_063933.1. NM_019880.3. [Q791T5-1 ]
XP_006524731.1. XM_006524668.1. [Q791T5-1 ]
XP_006524732.1. XM_006524669.1. [Q791T5-2 ]
XP_006524733.1. XM_006524670.1. [Q791T5-2 ]
UniGenei Mm.285322.
Mm.486273.

3D structure databases

ProteinModelPortali Q791T5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q791T5. 1 interaction.
STRINGi 10090.ENSMUSP00000093077.

PTM databases

PhosphoSitei Q791T5.

Proteomic databases

MaxQBi Q791T5.
PaxDbi Q791T5.
PRIDEi Q791T5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095427 ; ENSMUSP00000093077 ; ENSMUSG00000024012 . [Q791T5-1 ]
ENSMUST00000118366 ; ENSMUSP00000113021 ; ENSMUSG00000024012 . [Q791T5-2 ]
GeneIDi 56462.
KEGGi mmu:56462.
UCSCi uc008bst.1. mouse. [Q791T5-1 ]
uc008bsu.1. mouse. [Q791T5-2 ]

Organism-specific databases

CTDi 23787.
MGIi MGI:1929261. Mtch1.

Phylogenomic databases

eggNOGi NOG311439.
GeneTreei ENSGT00390000000020.
HOVERGENi HBG058632.
InParanoidi Q791T5.
KOi K17885.
OMAi FTYARHI.
OrthoDBi EOG7966H6.
PhylomeDBi Q791T5.
TreeFami TF313721.

Miscellaneous databases

NextBioi 312714.
PROi Q791T5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q791T5.
Bgeei Q791T5.
CleanExi MM_MTCH1.
Genevestigatori Q791T5.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 1 hit.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionarily conserved mitochondrial carrier gene family in mouse, human, and zebrafish."
    Jang J.S., Hahn Y., Park C., Chung J.H.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
  2. "Genomic sequence analysis in the mouse T-complex region."
    Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-389 (ISOFORM 2).
    Strain: NOD.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-389 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-389 (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Kidney and Mammary gland.

Entry informationi

Entry nameiMTCH1_MOUSE
AccessioniPrimary (citable) accession number: Q791T5
Secondary accession number(s): Q3U4W7
, Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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