Q791T5 (MTCH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial carrier homolog 1

Alternative name(s):
Mitochondrial carrier-like protein 1

Gene names

Name:

Mtch1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential mitochondrial transporter. May play a role in apoptosis By similarity.
Subunit structure	Interacts with PSEN1 By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 2 Solcar repeats.
Sequence caution	The sequence AAH23135.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH26436.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH27274.1 differs from that shown. Reason: Erroneous initiation. The sequence BAE32313.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q791T5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q791T5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     286-302: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Mitochondrial carrier homolog 1		PRO_0000232386
Regions
	Transmembrane	248 – 268	21	Helical; Potential
	Transmembrane	315 – 335	21	Helical; Potential
	Repeat	81 – 176	96	Solcar 1
	Repeat	192 – 280	89	Solcar 2
Amino acid modifications
	Modified residue	381	1	Phosphoserine Ref.5 Ref.6
Natural variations
	Alternative sequence	286 – 302	17	Missing in isoform 2.		VSP_017883
Experimental info
	Sequence conflict	10	1	P → A in BAE32313. Ref.3
	Sequence conflict	46	1	A → G in BAE32313. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: CCD3B23B6DF3CB02	FASTA	389	41,565
	10 20 30 40 50 60 MGASDPEVAP WAPGGAAGMA GAGAGAGARG GAPAGVEARA RDPPPAHRAH PRHPRPAAQP 70 80 90 100 110 120 SARRMDGGPG APGSGDNAPT TEALFVALGA GVTALSHPLL YVKLLIQVGH EPMPPTLGTN 130 140 150 160 170 180 VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR GLSPRLMSNA LSTVTRGSMK KVFPPDEMEQ 190 200 210 220 230 240 VSNKDDMKTS LKKVVKETSY EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI 250 260 270 280 290 300 GKIFKEEGLL GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG 310 320 330 340 350 360 SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLRAGLPPYS PVFKSWIHCW 370 380 KYLSVQGQLF RGSSLLFRRV SSGSCFALE
	Isoform 2 [UniParc]. Checksum: 8A432D696F328640	FASTA	372	39,941
	10 20 30 40 50 60 MGASDPEVAP WAPGGAAGMA GAGAGAGARG GAPAGVEARA RDPPPAHRAH PRHPRPAAQP 70 80 90 100 110 120 SARRMDGGPG APGSGDNAPT TEALFVALGA GVTALSHPLL YVKLLIQVGH EPMPPTLGTN 130 140 150 160 170 180 VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR GLSPRLMSNA LSTVTRGSMK KVFPPDEMEQ 190 200 210 220 230 240 VSNKDDMKTS LKKVVKETSY EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI 250 260 270 280 290 300 GKIFKEEGLL GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSFSQAL AIRSYTKFVM 310 320 330 340 350 360 GIAVSMLTYP FLLVGDLMAV NNCGLRAGLP PYSPVFKSWI HCWKYLSVQG QLFRGSSLLF 370 RRVSSGSCFA LE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionarily conserved mitochondrial carrier gene family in mouse, human, and zebrafish." Jang J.S., Hahn Y., Park C., Chung J.H. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
[2]	"Genomic sequence analysis in the mouse T-complex region." Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-389 (ISOFORM 2). Strain: NOD. Tissue: Thymus.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-389 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-389 (ISOFORM 2). Strain: FVB/N. Tissue: Kidney and Mammary gland.
[5]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, MASS SPECTROMETRY. Tissue: Brain cortex.
[6]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040292 Genomic DNA. Translation: BAA92860.1. AB040292 Genomic DNA. Translation: BAA92861.1. AF176007 mRNA. Translation: AAD52645.2. AF192558 mRNA. Translation: AAF12792.2. AY301264 Genomic DNA. Translation: AAP45196.1. AY301264 Genomic DNA. Translation: AAP45202.1. AK154010 mRNA. Translation: BAE32313.1. Different initiation. BC023135 mRNA. Translation: AAH23135.1. Different initiation. BC026436 mRNA. Translation: AAH26436.1. Different initiation. BC027274 mRNA. Translation: AAH27274.1. Different initiation.
IPI	IPI00137173. IPI00742287.
RefSeq	NP_063933.1. NM_019880.3.
UniGene	Mm.285322. Mm.486273.
3D structure databases
ProteinModelPortal	Q791T5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q791T5. 1 interaction.
STRING	10090.ENSMUSP00000093077.
PTM databases
PhosphoSite	Q791T5.
Proteomic databases
PaxDb	Q791T5.
PRIDE	Q791T5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000095427; ENSMUSP00000093077; ENSMUSG00000024012. ENSMUST00000118366; ENSMUSP00000113021; ENSMUSG00000024012.
GeneID	56462.
KEGG	mmu:56462.
UCSC	uc008bst.1. mouse. uc008bsu.1. mouse.
Organism-specific databases
CTD	23787.
MGI	MGI:1929261. Mtch1.
Phylogenomic databases
eggNOG	NOG311439.
GeneTree	ENSGT00390000000020.
HOVERGEN	HBG058632.
InParanoid	Q791T5.
OMA	KVGHEPM.
OrthoDB	EOG44BB2J.
Gene expression databases
ArrayExpress	Q791T5.
Bgee	Q791T5.
CleanEx	MM_MTCH1.
Genevestigator	Q791T5.
GermOnline	ENSMUSG00000024012. Mus musculus.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 1 hit. [Graphical view]
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	312714.
SOURCE	Search...

Entry information

Entry name

MTCH1_MOUSE

Accession

Primary (citable) accession number: Q791T5
Secondary accession number(s): Q3U4W7 , Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program