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Protein
Submitted name:

Valine--tRNA ligase

Gene

Vars

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Valine--tRNA ligaseImported
Submitted name:
Valyl-tRNA synthetase 2, isoform CRA_bImported
Submitted name:
Valyl-tRNA-synthetase G7a/Bat6Imported
Gene namesi
Name:VarsImported
Synonyms:G7aImported, Vars2Imported
ORF Names:mCG_15930Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:90675. Vars.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084572.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 219131GST C-terminalInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1235 – 126228Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation
Contains GST C-terminal domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
KOG0867. Eukaryota.
COG0525. LUCA.
HOVERGENiHBG017878.
KOiK01873.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
1.20.1050.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00043. GST_C. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF47616. SSF47616. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50405. GST_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q790I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILYVSPHP DAFPSLRALI AARYGEAGDG PGWGGPHPRI CLQPPPSSRT
60 70 80 90 100
PFPPPRLPAL EQGPGGLWVW GAPAVAQLLW PAGLGGPGGS RAAVLVQQWV
110 120 130 140 150
SYADTELIPA ACGATLPALG LRGPGQDPQA ALGALGKALN PLEDWLRLHT
160 170 180 190 200
YLAGDAPTLA DLAAVTALLL PFRYVLDPSA RRIWGNVTRW FNTCVRQPEF
210 220 230 240 250
RAVLGEVALY SGARSVTQQP GSEVIAPQKT PAQLKKEAKK REKLEKFQQK
260 270 280 290 300
QKTQQQPPHG EKKPKPEKKE KRDPGVITYD LPTPPGEKKD VSGAMPDSYS
310 320 330 340 350
PQYVEAAWYP WWERQGFFKP EYGRPSVSAP NPRGVFMMCI PPPNVTGSLH
360 370 380 390 400
LGHALTNAIQ DSLTRWHRMR GETTLWNPGC DHAGIATQVV VEKKLWKERG
410 420 430 440 450
LNRHQLGREA FLEEVWKWKA EKGDRIYHQL KKLGSSLDWD RACFTMDPKL
460 470 480 490 500
SATVTEAFVR LHEEGVIYRS TRLVNWSCTL NSAISDIEVD KKELTGRTLL
510 520 530 540 550
PVPGYKEKVE FGVLVSFAYK VQGSDSDEEV VVATTRIETM LGDVAVAVHP
560 570 580 590 600
KDPRYQHLKG KCVVHPFLSR SLPIVFDDFV DMEFGTGAVK ITPAHDQNDY
610 620 630 640 650
EVGQRHRLEA ISIMDSKGAL INVPPPFLGL PRFEARKAVL AALKERGLFR
660 670 680 690 700
GVKDNPMVVP LCNRSKDVVE PLLRPQWYVR CGEMAQAASA AVTRGDLRIL
710 720 730 740 750
PEAHQRTWHS WMDNIRDWCI SRQLWWGHRI PAYFITVHDP AVPPGEDPDG
760 770 780 790 800
RYWVSGRTEA EAREKAAREF GVSPDKISLQ QDEDVLDTWF SSGLFPFSIF
810 820 830 840 850
GWPNQSEDLS VFYPGTLLET GHDILFFWVA RMVMLGLKLT GKLPFREVYL
860 870 880 890 900
HAIVRDAHGR KMSKSLGNVI DPLDVIHGVS LQGLYDQLLN SNLDPSEVEK
910 920 930 940 950
AKEGQKADFP AGIPECGTDA LRFGLCAYTS QGRDINLDVN RILGYRHFCN
960 970 980 990 1000
KLWNATKFAL RGLGKGFVPS ATSKPEGHES LVDRWIRSRL TEAVRLSNEG
1010 1020 1030 1040 1050
FQAYDFPAIT TAQYSFWLYE LCDVYLECLK PVLNGVDQVA AECARQTLYT
1060 1070 1080 1090 1100
CLDVGLRLLS PFMPFVTEEL FQRLPRRTPK APASLCVTPY PEPSECSWKD
1110 1120 1130 1140 1150
PEAEAALELA LSITRAVRSL RADYNLTRTR PDCFLEVADE ATGALASAVS
1160 1170 1180 1190 1200
GYVQALASAG VVAVLALGAP APQGCAVAVA SDRCSIHLQL QGLVDPAREL
1210 1220 1230 1240 1250
GKLQAKRSEA QRQAQRLQER RAASSYSAKV PLEVQEADEA KLQQTEAELR
1260
KVDEAIALFQ KML
Length:1,263
Mass (Da):140,215
Last modified:May 10, 2005 - v1
Checksum:iB510E73284FCE26D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087117 Genomic DNA. No translation available.
AF397035 Genomic DNA. Translation: AAL14452.1.
AF397036 Genomic DNA. Translation: AAL14460.1.
CH466666 Genomic DNA. Translation: EDL26695.1.
CH466666 Genomic DNA. Translation: EDL26698.1.
RefSeqiNP_035820.3. NM_011690.3.
UniGeneiMm.28420.

Genome annotation databases

EnsembliENSMUST00000087315; ENSMUSP00000084572; ENSMUSG00000007029.
GeneIDi22321.
KEGGimmu:22321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087117 Genomic DNA. No translation available.
AF397035 Genomic DNA. Translation: AAL14452.1.
AF397036 Genomic DNA. Translation: AAL14460.1.
CH466666 Genomic DNA. Translation: EDL26695.1.
CH466666 Genomic DNA. Translation: EDL26698.1.
RefSeqiNP_035820.3. NM_011690.3.
UniGeneiMm.28420.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087315; ENSMUSP00000084572; ENSMUSG00000007029.
GeneIDi22321.
KEGGimmu:22321.

Organism-specific databases

CTDi7407.
MGIiMGI:90675. Vars.

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
KOG0867. Eukaryota.
COG0525. LUCA.
HOVERGENiHBG017878.
KOiK01873.

Miscellaneous databases

ChiTaRSiVars. mouse.
NextBioi302541.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
1.20.1050.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00043. GST_C. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF47616. SSF47616. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Coding sequences and levels of expression of Hsc70t are identical in mice with different Orch-1 alleles."
    Snoek M., Olavesen M.G., van Vugt H., Milner C.M., Teuscher C., Campbell R.D.
    Immunogenetics 40:159-162(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.AImported.
  2. "A novel gene, G7e, resembling a viral envelope gene, is located at the recombinational hot spot in the class III region of the mouse MHC."
    Snoek M., van Dinten L., van Vugt H.
    Genomics 38:5-12(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.AImported.
  3. "Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility."
    Snoek M., Teuscher C., van Vugt H.
    J. Immunol. 160:266-272(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.AImported.
  4. "The sequence and organization of the mouse valyl-tRNA synthetase gene G7a/Bat6 located in the MHC class III region."
    Snoek M., van Vugt H.
    Immunogenetics 49:468-470(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.AImported.
  5. "Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region."
    van Kooij M., de Groot K., van Vugt H., Aten J., Snoek M.
    Immunogenetics 53:656-661(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.AImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Ensembl
    Submitted (AUG-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ790I0_MOUSE
AccessioniPrimary (citable) accession number: Q790I0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.