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Protein

Homeodomain-only protein

Gene

Hopx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi3 – 62Homeobox; atypicalPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeodomain-only protein
Alternative name(s):
Global ischemia-induced gene 15B protein
Short name:
GIIg15b
Odd homeobox protein 1
Gene namesi
Name:Hopx
Synonyms:Giig15b, Hod, Hop, Ob1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi621841. Hopx.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491321 – 73Homeodomain-only proteinAdd BLAST73

Proteomic databases

PaxDbiQ78ZR5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000024689.
GenevisibleiQ78ZR5. RN.

Interactioni

Subunit structurei

Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such as HDAC2. Interacts with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044357.

Structurei

3D structure databases

ProteinModelPortaliQ78ZR5.
SMRiQ78ZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00390000017143.
HOGENOMiHOG000112932.
HOVERGENiHBG051921.
InParanoidiQ78ZR5.
OMAiKVSKHPD.
OrthoDBiEOG091G1BXE.
PhylomeDBiQ78ZR5.
TreeFamiTF330730.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q78ZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQTASGPT EDQVEILEYN FNKVNKHPDP TTLCLIAAEA GLTEEQTQKW
60 70
FKQRLAEWRR SEGLPSECRS VTD
Length:73
Mass (Da):8,282
Last modified:July 5, 2004 - v1
Checksum:i9D9B6D7F7A11C592
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6A → G in AAL85327 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492685 mRNA. Translation: AAM46837.1.
AF474162 mRNA. Translation: AAL85327.1.
BC070950 mRNA. Translation: AAH70950.1.
RefSeqiNP_598305.2. NM_133621.2.
UniGeneiRn.2989.

Genome annotation databases

EnsembliENSRNOT00000049774; ENSRNOP00000044357; ENSRNOG00000024689.
GeneIDi171160.
KEGGirno:171160.
UCSCiRGD:621841. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHOP_RAT
AccessioniPrimary (citable) accession number: Q78ZR5
Secondary accession number(s): Q8R4G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome