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Protein

Nucleosome assembly protein 1-like 4

Gene

Nap1l4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 4
Gene namesi
Name:Nap1l4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1316687. Nap1l4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 375374Nucleosome assembly protein 1-like 4PRO_0000236213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei5 – 51PhosphoserineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei49 – 491PhosphoserineCombined sources
Modified residuei51 – 511PhosphothreonineCombined sources
Modified residuei53 – 531PhosphoserineCombined sources
Modified residuei54 – 541PhosphoserineCombined sources
Modified residuei58 – 581PhosphothreonineBy similarity
Modified residuei105 – 1051N6-acetyllysineBy similarity
Modified residuei125 – 1251PhosphoserineCombined sources
Modified residuei146 – 1461N6-acetyllysineCombined sources
Modified residuei304 – 3041PhosphoserineCombined sources

Post-translational modificationi

Polyglutamylated and polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Polyglutamylated by TTLL4.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ78ZA7.
MaxQBiQ78ZA7.
PaxDbiQ78ZA7.
PRIDEiQ78ZA7.

PTM databases

iPTMnetiQ78ZA7.

Expressioni

Gene expression databases

BgeeiQ78ZA7.
CleanExiMM_NAP1L4.
ExpressionAtlasiQ78ZA7. baseline and differential.
GenevisibleiQ78ZA7. MM.

Interactioni

Protein-protein interaction databases

BioGridi201692. 3 interactions.
IntActiQ78ZA7. 3 interactions.
MINTiMINT-2514278.
STRINGi10090.ENSMUSP00000072510.

Structurei

3D structure databases

ProteinModelPortaliQ78ZA7.
SMRiQ78ZA7. Positions 53-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi265 – 2717Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi126 – 1316Poly-Glu
Compositional biasi301 – 31010Asp/Glu-rich (acidic)
Compositional biasi347 – 37024Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ78ZA7.
KOiK11282.
OMAiDDADVNP.
OrthoDBiEOG73Z2T8.
PhylomeDBiQ78ZA7.
TreeFamiTF314349.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78ZA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENSLSDGG PADSVEAAKN ASNTEKLTDQ VMQNPQVLAA LQERLDNVSH
60 70 80 90 100
TPSSYIETLP KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ
110 120 130 140 150
PLFDKRREFI TGDVEPTDAE SAWHSENEEE DKLAGDMKNK VVIAEKEAAT
160 170 180 190 200
VEELNPKGIP EFWFTIFRNV DMLSELVQEY DEPILKHLQD IKVKFSDPGQ
210 220 230 240 250
PMSFVLEFHF EPNDYFTNPV LTKTYKMKSE PDKADPFSFE GPEIVDCDGC
260 270 280 290 300
TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFSPLKASG
310 320 330 340 350
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE
360 370
EGEEEELEGD EEGEDEDDAD VNPKV
Length:375
Mass (Da):42,679
Last modified:July 5, 2004 - v1
Checksum:iA249E440F09072A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002198 mRNA. Translation: CAA05245.1.
AJ276505 Genomic DNA. Translation: CAC16399.1.
CCDSiCCDS40197.1.
RefSeqiNP_001272418.1. NM_001285489.1.
NP_001272419.1. NM_001285490.1.
NP_032698.1. NM_008672.3.
UniGeneiMm.294625.

Genome annotation databases

EnsembliENSMUST00000072727; ENSMUSP00000072510; ENSMUSG00000059119.
GeneIDi17955.
KEGGimmu:17955.
UCSCiuc009kpl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002198 mRNA. Translation: CAA05245.1.
AJ276505 Genomic DNA. Translation: CAC16399.1.
CCDSiCCDS40197.1.
RefSeqiNP_001272418.1. NM_001285489.1.
NP_001272419.1. NM_001285490.1.
NP_032698.1. NM_008672.3.
UniGeneiMm.294625.

3D structure databases

ProteinModelPortaliQ78ZA7.
SMRiQ78ZA7. Positions 53-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201692. 3 interactions.
IntActiQ78ZA7. 3 interactions.
MINTiMINT-2514278.
STRINGi10090.ENSMUSP00000072510.

PTM databases

iPTMnetiQ78ZA7.

Proteomic databases

EPDiQ78ZA7.
MaxQBiQ78ZA7.
PaxDbiQ78ZA7.
PRIDEiQ78ZA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072727; ENSMUSP00000072510; ENSMUSG00000059119.
GeneIDi17955.
KEGGimmu:17955.
UCSCiuc009kpl.2. mouse.

Organism-specific databases

CTDi4676.
MGIiMGI:1316687. Nap1l4.

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ78ZA7.
KOiK11282.
OMAiDDADVNP.
OrthoDBiEOG73Z2T8.
PhylomeDBiQ78ZA7.
TreeFamiTF314349.

Miscellaneous databases

PROiQ78ZA7.
SOURCEiSearch...

Gene expression databases

BgeeiQ78ZA7.
CleanExiMM_NAP1L4.
ExpressionAtlasiQ78ZA7. baseline and differential.
GenevisibleiQ78ZA7. MM.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5."
    Paulsen M., Davies K.R., Bowden L.M., Villar A.J., Franck O., Fuermann M., Dean W.L., Moore T.F., Rodrigues N., Davies K.E., Hu R.-J., Feinberg A.P., Maher E.R., Reik W., Walter J.
    Hum. Mol. Genet. 7:1149-1159(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting."
    Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R., Lane N., Reik W., Walter J.
    Hum. Mol. Genet. 9:2691-2706(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "A targeted multienzyme mechanism for selective microtubule polyglutamylation."
    van Dijk J., Rogowski K., Miro J., Lacroix B., Edde B., Janke C.
    Mol. Cell 26:437-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYGLUTAMYLATION.
    Strain: C57BL/6J.
    Tissue: Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; THR-51; SER-53; SER-54; SER-125 AND SER-304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiNP1L4_MOUSE
AccessioniPrimary (citable) accession number: Q78ZA7
Secondary accession number(s): O88701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.