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Protein

DnaJ homolog subfamily C member 15

Gene

Dnajc15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9 (By similarity). Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP.By similarity1 Publication

GO - Biological processi

  • cellular response to starvation Source: MGI
  • negative regulation of mitochondrial electron transport, NADH to ubiquinone Source: MGI
  • negative regulation of protein complex assembly Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of lipid metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 15
Gene namesi
Name:Dnajc15
Synonyms:Dnajd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1913398. Dnajc15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei38 – 5417HelicalSequence analysisAdd
BLAST
Topological domaini55 – 14995Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mutant animals are viable. Both male and female are fertile and do not exhibit any obvious malformations or behavioral abnormalities. CD8+ T-cell mitochondria are hyperpolarized, compared to their wild-type counterparts. In fasted mutant animals, livers do not exhibit any signs of steatosis, but accumulate glycogen, possibly due to a sustained mitochondrial oxidation that leads to rapid metabolism of lipids, hence minimizing their accumulation in the liver and favoring glycogenesis. During fasting, loss of white fat is also more prominent than in wild type animals.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149DnaJ homolog subfamily C member 15PRO_0000247140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ78YY6.
MaxQBiQ78YY6.
PaxDbiQ78YY6.
PeptideAtlasiQ78YY6.
PRIDEiQ78YY6.

PTM databases

iPTMnetiQ78YY6.
PhosphoSiteiQ78YY6.

Expressioni

Tissue specificityi

Expressed at high levels in liver, heart, at moderate levels in kidney and, at very low levels, in lung (at protein level). High expression levels in testis. Highly expressed in CD8+ T-cells, but barely detectable in CD4+ T-cells (at protein level). Almost undetectable in B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000022013.
CleanExiMM_DNAJC15.
GenevisibleiQ78YY6. MM.

Interactioni

Subunit structurei

Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity (By similarity). Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022590.

Structurei

3D structure databases

ProteinModelPortaliQ78YY6.
SMRiQ78YY6. Positions 81-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 14956JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0723. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00390000017303.
HOGENOMiHOG000115841.
HOVERGENiHBG057483.
InParanoidiQ78YY6.
KOiK09535.
OMAiHRRVMIL.
OrthoDBiEOG091G116P.
PhylomeDBiQ78YY6.
TreeFamiTF320584.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q78YY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGGGVTSR EGLRYAEYLP PSAQRSDADI DHTAGRRLLA VGLGVAAVAF
60 70 80 90 100
AGRYAFQIWK PLEQVITATA RKISSPSFSS YYKGGFEQKM SKREASLILG
110 120 130 140
VSPSAGKAKI RTAHKRIMIL NHPDKGGSPY LASKINEAKD LLEASSKAN
Length:149
Mass (Da):15,953
Last modified:July 5, 2004 - v1
Checksum:i033EE8F425EC6DF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002598 mRNA. Translation: BAB22219.1.
BC027509 mRNA. Translation: AAH27509.1.
CCDSiCCDS27292.1.
RefSeqiNP_079660.1. NM_025384.3.
UniGeneiMm.248046.

Genome annotation databases

EnsembliENSMUST00000022590; ENSMUSP00000022590; ENSMUSG00000022013.
GeneIDi66148.
KEGGimmu:66148.
UCSCiuc007usc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002598 mRNA. Translation: BAB22219.1.
BC027509 mRNA. Translation: AAH27509.1.
CCDSiCCDS27292.1.
RefSeqiNP_079660.1. NM_025384.3.
UniGeneiMm.248046.

3D structure databases

ProteinModelPortaliQ78YY6.
SMRiQ78YY6. Positions 81-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022590.

PTM databases

iPTMnetiQ78YY6.
PhosphoSiteiQ78YY6.

Proteomic databases

EPDiQ78YY6.
MaxQBiQ78YY6.
PaxDbiQ78YY6.
PeptideAtlasiQ78YY6.
PRIDEiQ78YY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022590; ENSMUSP00000022590; ENSMUSG00000022013.
GeneIDi66148.
KEGGimmu:66148.
UCSCiuc007usc.1. mouse.

Organism-specific databases

CTDi29103.
MGIiMGI:1913398. Dnajc15.

Phylogenomic databases

eggNOGiKOG0723. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00390000017303.
HOGENOMiHOG000115841.
HOVERGENiHBG057483.
InParanoidiQ78YY6.
KOiK09535.
OMAiHRRVMIL.
OrthoDBiEOG091G116P.
PhylomeDBiQ78YY6.
TreeFamiTF320584.

Miscellaneous databases

PROiQ78YY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022013.
CleanExiMM_DNAJC15.
GenevisibleiQ78YY6. MM.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDJC15_MOUSE
AccessioniPrimary (citable) accession number: Q78YY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.