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Protein

Oligosaccharyltransferase complex subunit OSTC

Gene

Ostc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Oligosaccharyltransferase complex subunit OSTC
Gene namesi
Name:Ostc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913607. Ostc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 83ExtracellularSequence analysisAdd BLAST30
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 117CytoplasmicSequence analysisAdd BLAST13
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 149ExtracellularSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206031 – 149Oligosaccharyltransferase complex subunit OSTCAdd BLAST149

Proteomic databases

EPDiQ78XF5.
MaxQBiQ78XF5.
PaxDbiQ78XF5.
PeptideAtlasiQ78XF5.
PRIDEiQ78XF5.

PTM databases

iPTMnetiQ78XF5.
PhosphoSitePlusiQ78XF5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041084.
CleanExiMM_2310008M10RIK.
GenevisibleiQ78XF5. MM.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity).By similarity

Protein-protein interaction databases

BioGridi211409. 1 interactor.
IntActiQ78XF5. 3 interactors.
MINTiMINT-4124750.
STRINGi10090.ENSMUSP00000046480.

Structurei

3D structure databases

ProteinModelPortaliQ78XF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OSTC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3356. Eukaryota.
ENOG4111G0G. LUCA.
GeneTreeiENSGT00390000001376.
HOGENOMiHOG000006225.
HOVERGENiHBG056614.
InParanoidiQ78XF5.
OMAiWIFMRMK.
OrthoDBiEOG091G0RRT.
PhylomeDBiQ78XF5.
TreeFamiTF323315.

Family and domain databases

InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q78XF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLYRVPFL VLECPNLKLK KPPWVHMPSA MTVYALVVVS YFLITGGIIY
60 70 80 90 100
DVIVEPPSVG SMTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG
110 120 130 140
FIILDRSNAP NIPKLNRFLL LFIGFVCVLL SFFMARVFMR MKLPGYLMG
Length:149
Mass (Da):16,815
Last modified:July 5, 2004 - v1
Checksum:iE5929C5B9D9458B4
GO

Sequence cautioni

The sequence BAB28595 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009237 mRNA. Translation: BAB26158.1.
AK011085 mRNA. Translation: BAB27389.1.
AK013011 mRNA. Translation: BAB28595.2. Different initiation.
AK135332 mRNA. Translation: BAE22491.1.
BC021935 mRNA. Translation: AAH21935.1.
CCDSiCCDS38639.1.
RefSeqiNP_079785.1. NM_025509.3.
UniGeneiMm.300697.

Genome annotation databases

EnsembliENSMUST00000043937; ENSMUSP00000046480; ENSMUSG00000041084.
GeneIDi66357.
KEGGimmu:66357.
UCSCiuc008rjc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009237 mRNA. Translation: BAB26158.1.
AK011085 mRNA. Translation: BAB27389.1.
AK013011 mRNA. Translation: BAB28595.2. Different initiation.
AK135332 mRNA. Translation: BAE22491.1.
BC021935 mRNA. Translation: AAH21935.1.
CCDSiCCDS38639.1.
RefSeqiNP_079785.1. NM_025509.3.
UniGeneiMm.300697.

3D structure databases

ProteinModelPortaliQ78XF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211409. 1 interactor.
IntActiQ78XF5. 3 interactors.
MINTiMINT-4124750.
STRINGi10090.ENSMUSP00000046480.

PTM databases

iPTMnetiQ78XF5.
PhosphoSitePlusiQ78XF5.

Proteomic databases

EPDiQ78XF5.
MaxQBiQ78XF5.
PaxDbiQ78XF5.
PeptideAtlasiQ78XF5.
PRIDEiQ78XF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043937; ENSMUSP00000046480; ENSMUSG00000041084.
GeneIDi66357.
KEGGimmu:66357.
UCSCiuc008rjc.2. mouse.

Organism-specific databases

CTDi58505.
MGIiMGI:1913607. Ostc.

Phylogenomic databases

eggNOGiKOG3356. Eukaryota.
ENOG4111G0G. LUCA.
GeneTreeiENSGT00390000001376.
HOGENOMiHOG000006225.
HOVERGENiHBG056614.
InParanoidiQ78XF5.
OMAiWIFMRMK.
OrthoDBiEOG091G0RRT.
PhylomeDBiQ78XF5.
TreeFamiTF323315.

Miscellaneous databases

PROiQ78XF5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041084.
CleanExiMM_2310008M10RIK.
GenevisibleiQ78XF5. MM.

Family and domain databases

InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTC_MOUSE
AccessioniPrimary (citable) accession number: Q78XF5
Secondary accession number(s): Q9CPZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.