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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 2

Gene

Camk2n2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca2+/calmodulin on CAMK2 (By similarity).By similarity

GO - Molecular functioni

  • calcium-dependent protein kinase inhibitor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Alternative name(s):
CaM-KII inhibitory protein
Short name:
CaM-KIIN
Gene namesi
Name:Camk2n2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1920297. Camk2n2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7979Calcium/calmodulin-dependent protein kinase II inhibitor 2PRO_0000327267Add
BLAST

Proteomic databases

MaxQBiQ78WH7.
PaxDbiQ78WH7.
PRIDEiQ78WH7.

PTM databases

iPTMnetiQ78WH7.
PhosphoSiteiQ78WH7.

Expressioni

Gene expression databases

BgeeiQ78WH7.
ExpressionAtlasiQ78WH7. baseline and differential.
GenevisibleiQ78WH7. MM.

Interactioni

Subunit structurei

Interacts with CAMK2A and CAMK2B in the presence of Ca2+/calmodulin or after autophosphorylation.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057368.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 6927Inhibitory domainBy similarityAdd
BLAST

Domaini

The inhibitory domain blocks CAMK2 binding to GRIN2B.By similarity

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0NK. Eukaryota.
ENOG411202V. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ78WH7.
OMAiLQDTNTF.
OrthoDBiEOG7TF7CN.
TreeFamiTF333175.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q78WH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILPYGED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ
60 70
IGRAKRVVIE DDRIDDVLKG MGEKPPSGV
Length:79
Mass (Da):8,628
Last modified:July 5, 2004 - v1
Checksum:iB34820F5D6417CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013788 mRNA. Translation: BAB28995.1.
CCDSiCCDS49795.1.
RefSeqiNP_082696.1. NM_028420.2.
UniGeneiMm.425977.

Genome annotation databases

EnsembliENSMUST00000052939; ENSMUSP00000057368; ENSMUSG00000051146.
GeneIDi73047.
KEGGimmu:73047.
UCSCiuc007yqk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013788 mRNA. Translation: BAB28995.1.
CCDSiCCDS49795.1.
RefSeqiNP_082696.1. NM_028420.2.
UniGeneiMm.425977.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057368.

PTM databases

iPTMnetiQ78WH7.
PhosphoSiteiQ78WH7.

Proteomic databases

MaxQBiQ78WH7.
PaxDbiQ78WH7.
PRIDEiQ78WH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052939; ENSMUSP00000057368; ENSMUSG00000051146.
GeneIDi73047.
KEGGimmu:73047.
UCSCiuc007yqk.2. mouse.

Organism-specific databases

CTDi94032.
MGIiMGI:1920297. Camk2n2.

Phylogenomic databases

eggNOGiENOG410J0NK. Eukaryota.
ENOG411202V. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ78WH7.
OMAiLQDTNTF.
OrthoDBiEOG7TF7CN.
TreeFamiTF333175.

Miscellaneous databases

PROiQ78WH7.
SOURCEiSearch...

Gene expression databases

BgeeiQ78WH7.
ExpressionAtlasiQ78WH7. baseline and differential.
GenevisibleiQ78WH7. MM.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCK2N2_MOUSE
AccessioniPrimary (citable) accession number: Q78WH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.