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Protein

Vacuolar ATPase assembly integral membrane protein Vma21

Gene

Vma21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar ATPase assembly integral membrane protein Vma21UniRule annotation
Gene namesi
Name:Vma21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1914298. Vma21.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicUniRule annotationAdd BLAST25
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Topological domaini47 – 65LumenalUniRule annotationAdd BLAST19
Transmembranei66 – 86HelicalUniRule annotationAdd BLAST21
Topological domaini87 – 101CytoplasmicUniRule annotationAdd BLAST15

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315001 – 101Vacuolar ATPase assembly integral membrane protein Vma21Add BLAST101

Proteomic databases

PaxDbiQ78T54.
PeptideAtlasiQ78T54.
PRIDEiQ78T54.
TopDownProteomicsiQ78T54-1. [Q78T54-1]
Q78T54-2. [Q78T54-2]

PTM databases

iPTMnetiQ78T54.
PhosphoSitePlusiQ78T54.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073131.
ExpressionAtlasiQ78T54. baseline and differential.
GenevisibleiQ78T54. MM.

Interactioni

Subunit structurei

Associates with the V0 complex of the vacuolar ATPase (V-ATPase).UniRule annotation

Protein-protein interaction databases

IntActiQ78T54. 1 interactor.
STRINGi10090.ENSMUSP00000110223.

Structurei

3D structure databases

SMRiQ78T54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMA21 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4783. Eukaryota.
ENOG411241C. LUCA.
GeneTreeiENSGT00390000017980.
HOGENOMiHOG000154822.
InParanoidiQ78T54.
TreeFamiTF314021.

Family and domain databases

HAMAPiMF_03058. VMA21. 1 hit.
InterProiView protein in InterPro
IPR019013. Vma21.
PANTHERiPTHR31792. PTHR31792. 1 hit.
PfamiView protein in Pfam
PF09446. VMA21. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q78T54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERLDKAALN ALQPPEFRNE NSLAATLKTL LFFTALMITV PIGLYFTTKA
60 70 80 90 100
YIFEGALGMS NRDSYFYAAI VAVVAVHVVL ALFVYVAWNE GSRQWREGKQ

D
Length:101
Mass (Da):11,365
Last modified:July 5, 2004 - v1
Checksum:i5BDB68CC836190E1
GO
Isoform 2 (identifier: Q78T54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-101: GALGMSNRDS...SRQWREGKQD → ALRTKASLIDTLQLSSGRKKISPFRALQL

Note: No experimental confirmation available.
Show »
Length:83
Mass (Da):9,333
Checksum:i75E14FA57F836133
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03746455 – 101GALGM…EGKQD → ALRTKASLIDTLQLSSGRKK ISPFRALQL in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ748652 mRNA. Translation: CAG38686.1.
AK049296 mRNA. Translation: BAC33664.1.
AK049488 mRNA. Translation: BAC33774.1.
AK164163 mRNA. Translation: BAE37657.1.
AK138582 mRNA. Translation: BAE23704.1.
BC028317 mRNA. Translation: AAH28317.1.
BC094639 mRNA. Translation: AAH94639.1.
CCDSiCCDS41000.1. [Q78T54-1]
RefSeqiNP_001074825.1. NM_001081356.3. [Q78T54-1]
NP_001277710.1. NM_001290781.1.
UniGeneiMm.371816.
Mm.41102.
Mm.487774.

Genome annotation databases

EnsembliENSMUST00000114576; ENSMUSP00000110223; ENSMUSG00000073131. [Q78T54-1]
GeneIDi67048.
KEGGimmu:67048.
UCSCiuc009tkf.3. mouse. [Q78T54-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVMA21_MOUSE
AccessioniPrimary (citable) accession number: Q78T54
Secondary accession number(s): Q3UUC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families