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Protein

Staphylococcal nuclease domain-containing protein 1

Gene

Snd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Plays a role in cell viability (By similarity). Functions as a transcriptional coactivator for STAT5.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Staphylococcal nuclease domain-containing protein 1
Alternative name(s):
100 kDa coactivator
p100 co-activator
Gene namesi
Name:Snd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1929266. Snd1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Melanosome By similarity

  • Note: In IL-4 stimulated cells colocalizes with STAT6 in the nucleus.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • dense body Source: MGI
  • extracellular exosome Source: MGI
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
  • RISC complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 910909Staphylococcal nuclease domain-containing protein 1PRO_0000183181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei103 – 1031PhosphothreonineBy similarity
Modified residuei193 – 1931N6-acetyllysineBy similarity
Modified residuei235 – 2351PhosphothreonineCombined sources
Modified residuei240 – 2401PhosphothreonineBy similarity
Modified residuei426 – 4261PhosphoserineCombined sources
Modified residuei641 – 6411N6-acetyllysineCombined sources
Modified residuei645 – 6451PhosphoserineBy similarity
Modified residuei779 – 7791PhosphothreonineBy similarity
Modified residuei785 – 7851PhosphoserineBy similarity
Modified residuei909 – 9091PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by PIM1 in vitro.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ78PY7.
MaxQBiQ78PY7.
PaxDbiQ78PY7.
PRIDEiQ78PY7.

PTM databases

iPTMnetiQ78PY7.
PhosphoSiteiQ78PY7.
SwissPalmiQ78PY7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001424.
ExpressionAtlasiQ78PY7. baseline and differential.
GenevisibleiQ78PY7. MM.

Interactioni

Subunit structurei

Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A (By similarity). Interacts with STAT5.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MtdhQ80WJ74EBI-529864,EBI-774530

Protein-protein interaction databases

BioGridi208002. 5 interactions.
DIPiDIP-32118N.
IntActiQ78PY7. 9 interactions.
MINTiMINT-1863307.
STRINGi10090.ENSMUSP00000001460.

Structurei

3D structure databases

ProteinModelPortaliQ78PY7.
SMRiQ78PY7. Positions 17-333, 340-897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 166149TNase-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini193 – 328136TNase-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini341 – 496156TNase-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini525 – 660136TNase-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini729 – 78759TudorPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi321 – 3255Nuclear localization signalSequence analysis
Motifi388 – 3925Nuclear localization signalSequence analysis

Sequence similaritiesi

Contains 4 TNase-like domains.PROSITE-ProRule annotation
Contains 1 Tudor domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2039. Eukaryota.
COG1525. LUCA.
GeneTreeiENSGT00510000047270.
HOGENOMiHOG000173592.
HOVERGENiHBG057234.
InParanoidiQ78PY7.
KOiK15979.
OMAiIQVPQDD.
OrthoDBiEOG091G027G.
PhylomeDBiQ78PY7.
TreeFamiTF300615.

Family and domain databases

Gene3Di2.40.50.90. 5 hits.
InterProiIPR016685. Silence_cplx_Nase-comp_TudorSN.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002071. Thermonucl_AS.
IPR002999. Tudor.
[Graphical view]
PfamiPF00565. SNase. 5 hits.
PF00567. TUDOR. 1 hit.
[Graphical view]
PIRSFiPIRSF017179. RISC-Tudor-SN. 1 hit.
SMARTiSM00318. SNc. 4 hits.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 6 hits.
PROSITEiPS01284. TNASE_2. 1 hit.
PS50830. TNASE_3. 4 hits.
PS50304. TUDOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78PY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSAQSSGS SGGPAVPTVQ RGIVKMVLSG CAIIVRGQPR GGPPPERQIN
60 70 80 90 100
LSNIRAGNLA RRAAATQPDG KDTPDEPWAF PAREFLRKKL IGKEVCFTIE
110 120 130 140 150
NKTPQGREYG MIYLGKDTNG ENIAESLVAE GLATRREGMR ANNPEQNRLS
160 170 180 190 200
ECEEQAKASK KGMWSEGNGS HTIRDLKYTI ENPRHFVDSH HQKPVNAIIE
210 220 230 240 250
HVRDGSVVRA LLLPGHHLVT VMLSGIKCPT FRRETDGSET PEPFAAEAKF
260 270 280 290 300
FTESRLLQRD VQIILESCHN QNLLGTILHP NGNITELLLK EGFARCVDWS
310 320 330 340 350
IAVYTRGAEK LRAAERFAKE RRLRIWRDYV PPTANLDQKD KQFVAKVMQV
360 370 380 390 400
LNADAIVVKL NSGDYKTIHL SSIRPPRLEG DNIQDKNKKL RPLYDIPYMF
410 420 430 440 450
EAREFLRKKL IGKKVNVTVD YIRPASPATE TVPAFSERTC ATVTIGGINI
460 470 480 490 500
AEALVSKGLA TVIRYRQDDD QRSSHYDELL AAEARAIKNG KGLHSKKEVP
510 520 530 540 550
IHRVADISGD TQKAKQFLPF LQRAGRSEAV VEYVFSGSRL KLYLPKETCL
560 570 580 590 600
ITFLLAGIEC PRGARNLPGL VQEGEPFSEE ATLFTKELVL QREVEVEVES
610 620 630 640 650
MDKAGNFIGW LHMDGANLSV LLVEQALSKV HFTAERSAYY KPLLSAEEAA
660 670 680 690 700
KQRKEKVWAH YEERPVEEVM PVLEEKERSA SYKPVFVTEI TDDLHFYVQD
710 720 730 740 750
VETGTQLEKL MENMRNDISS HPPVEGSYAP RRGEFCIAKF VDGEWYRARV
760 770 780 790 800
EKVESPAKVH VFYIDYGNRE ILPSTRLGTL PPAFSTRVLP AQATEYAFAF
810 820 830 840 850
IQVPQDEDAR TDAVDSVVRD IQNTQCLLNV EHLSASCPHV TLQFADSKGD
860 870 880 890 900
VGLGLVKEGL VMVEVRKEKQ FQKVITEYLN AQESAKSARL NLWRYGDFRA
910
DDADEFGYSR
Length:910
Mass (Da):102,088
Last modified:July 5, 2004 - v1
Checksum:i7A31459E9274D0B6
GO

Sequence cautioni

The sequence BAA84944 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081V → A in BAA84944 (Ref. 1) Curated
Sequence conflicti908 – 9103Missing in BAA84944 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021491 mRNA. Translation: BAA84944.1. Different initiation.
AK088028 mRNA. Translation: BAC40105.1.
AK161591 mRNA. Translation: BAE36479.1.
BC007126 mRNA. Translation: AAH07126.3.
CCDSiCCDS19953.1.
RefSeqiNP_062750.2. NM_019776.2.
UniGeneiMm.439987.

Genome annotation databases

EnsembliENSMUST00000001460; ENSMUSP00000001460; ENSMUSG00000001424.
GeneIDi56463.
KEGGimmu:56463.
UCSCiuc009bct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021491 mRNA. Translation: BAA84944.1. Different initiation.
AK088028 mRNA. Translation: BAC40105.1.
AK161591 mRNA. Translation: BAE36479.1.
BC007126 mRNA. Translation: AAH07126.3.
CCDSiCCDS19953.1.
RefSeqiNP_062750.2. NM_019776.2.
UniGeneiMm.439987.

3D structure databases

ProteinModelPortaliQ78PY7.
SMRiQ78PY7. Positions 17-333, 340-897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208002. 5 interactions.
DIPiDIP-32118N.
IntActiQ78PY7. 9 interactions.
MINTiMINT-1863307.
STRINGi10090.ENSMUSP00000001460.

PTM databases

iPTMnetiQ78PY7.
PhosphoSiteiQ78PY7.
SwissPalmiQ78PY7.

Proteomic databases

EPDiQ78PY7.
MaxQBiQ78PY7.
PaxDbiQ78PY7.
PRIDEiQ78PY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001460; ENSMUSP00000001460; ENSMUSG00000001424.
GeneIDi56463.
KEGGimmu:56463.
UCSCiuc009bct.1. mouse.

Organism-specific databases

CTDi27044.
MGIiMGI:1929266. Snd1.

Phylogenomic databases

eggNOGiKOG2039. Eukaryota.
COG1525. LUCA.
GeneTreeiENSGT00510000047270.
HOGENOMiHOG000173592.
HOVERGENiHBG057234.
InParanoidiQ78PY7.
KOiK15979.
OMAiIQVPQDD.
OrthoDBiEOG091G027G.
PhylomeDBiQ78PY7.
TreeFamiTF300615.

Miscellaneous databases

ChiTaRSiSnd1. mouse.
PROiQ78PY7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001424.
ExpressionAtlasiQ78PY7. baseline and differential.
GenevisibleiQ78PY7. MM.

Family and domain databases

Gene3Di2.40.50.90. 5 hits.
InterProiIPR016685. Silence_cplx_Nase-comp_TudorSN.
IPR016071. Staphylococal_nuclease_OB-fold.
IPR002071. Thermonucl_AS.
IPR002999. Tudor.
[Graphical view]
PfamiPF00565. SNase. 5 hits.
PF00567. TUDOR. 1 hit.
[Graphical view]
PIRSFiPIRSF017179. RISC-Tudor-SN. 1 hit.
SMARTiSM00318. SNc. 4 hits.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 6 hits.
PROSITEiPS01284. TNASE_2. 1 hit.
PS50830. TNASE_3. 4 hits.
PS50304. TUDOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSND1_MOUSE
AccessioniPrimary (citable) accession number: Q78PY7
Secondary accession number(s): Q3TT46, Q922L5, Q9R0S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.