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Protein

Dynein light chain 2, cytoplasmic

Gene

Dynll2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

Caution

As DLC8 is commonly used to refer to both DLC1 and DLC2 proteins, it is preferable to adopt the following nomenclature (see PubMed:11602781) where DLC8a and DLC8b corresponds respectively to DLC1 and DLC2.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-139910 Activation of BMF and translocation to mitochondria
R-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-1632852 Macroautophagy
R-RNO-2132295 MHC class II antigen presentation
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-RNO-5620924 Intraflagellar transport
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-RNO-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
Dynein light chain LC8-type 2
Gene namesi
Name:Dynll2
Synonyms:Dlc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619860 Dynll2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951341 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

PaxDbiQ78P75
PRIDEiQ78P75

PTM databases

iPTMnetiQ78P75
PhosphoSitePlusiQ78P75
SwissPalmiQ78P75

Expressioni

Gene expression databases

BgeeiENSRNOG00000008921
GenevisibleiQ78P75 RN

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF and GPHN. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41Interaction with myosin V motor complexBy similarity1

GO - Molecular functioni

  • dynein intermediate chain binding Source: GO_Central
  • dynein light intermediate chain binding Source: GO_Central
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi250846, 2 interactors
IntActiQ78P75, 1 interactor
MINTiQ78P75
STRINGi10116.ENSRNOP00000012279

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi16 – 31Combined sources16
Helixi36 – 50Combined sources15
Beta strandi57 – 61Combined sources5
Beta strandi64 – 66Combined sources3
Turni67 – 69Combined sources3
Beta strandi71 – 78Combined sources8
Beta strandi81 – 87Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWJNMR-A1-89[»]
1PWKNMR-A1-89[»]
ProteinModelPortaliQ78P75
SMRiQ78P75
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ78P75

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430 Eukaryota
ENOG4111NK2 LUCA
GeneTreeiENSGT00390000000378
HOVERGENiHBG002133
InParanoidiQ78P75
KOiK10418
OMAiKGPTWHC
OrthoDBiEOG091G15JY
PhylomeDBiQ78P75
TreeFamiTF300264

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR019763 Dynein_light_1/2_CS
IPR001372 Dynein_light_chain_typ-1/2
PANTHERiPTHR11886 PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221 Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375 Dynein_light, 1 hit
SUPFAMiSSF54648 SSF54648, 1 hit
PROSITEiView protein in PROSITE
PS01239 DYNEIN_LIGHT_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q78P75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:July 5, 2004 - v1
Checksum:i45364D32C0077F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034383 mRNA Translation: AAK57536.1
BC061874 mRNA Translation: AAH61874.1
RefSeqiNP_542428.1, NM_080697.2
XP_006247139.1, XM_006247077.3
UniGeneiRn.36362

Genome annotation databases

EnsembliENSRNOT00000012279; ENSRNOP00000012279; ENSRNOG00000008921
GeneIDi140734
KEGGirno:140734

Similar proteinsi

Entry informationi

Entry nameiDYL2_RAT
AccessioniPrimary (citable) accession number: Q78P75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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