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Protein

Dynein light chain 2, cytoplasmic

Gene

Dynll2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

GO - Molecular functioni

  • cytoskeletal protein binding Source: RGD
  • motor activity Source: UniProtKB-KW

GO - Biological processi

  • microtubule-based process Source: InterPro
  • synaptic target recognition Source: RGD
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-139910. Activation of BMF and translocation to mitochondria.
R-RNO-1632852. Macroautophagy.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-5620924. Intraflagellar transport.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
Dynein light chain LC8-type 2
Gene namesi
Name:Dynll2
Synonyms:Dlc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619860. Dynll2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: Ensembl
  • cytoplasm Source: RGD
  • dynein complex Source: UniProtKB-KW
  • membrane Source: Ensembl
  • microtubule Source: UniProtKB-KW
  • myosin complex Source: Ensembl
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951341 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

PaxDbiQ78P75.
PRIDEiQ78P75.

PTM databases

iPTMnetiQ78P75.
PhosphoSitePlusiQ78P75.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008921.
GenevisibleiQ78P75. RN.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF and GPHN. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41Interaction with myosin V motor complexBy similarity1

GO - Molecular functioni

  • cytoskeletal protein binding Source: RGD

Protein-protein interaction databases

BioGridi250846. 1 interactor.
IntActiQ78P75. 1 interactor.
MINTiMINT-4577592.
STRINGi10116.ENSRNOP00000012279.

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi16 – 31Combined sources16
Helixi36 – 50Combined sources15
Beta strandi57 – 61Combined sources5
Beta strandi64 – 66Combined sources3
Turni67 – 69Combined sources3
Beta strandi71 – 78Combined sources8
Beta strandi81 – 87Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWJNMR-A1-89[»]
1PWKNMR-A1-89[»]
ProteinModelPortaliQ78P75.
SMRiQ78P75.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ78P75.

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ78P75.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG091G15JY.
PhylomeDBiQ78P75.
TreeFamiTF300264.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q78P75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:July 5, 2004 - v1
Checksum:i45364D32C0077F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034383 mRNA. Translation: AAK57536.1.
BC061874 mRNA. Translation: AAH61874.1.
RefSeqiNP_542428.1. NM_080697.2.
XP_006247139.1. XM_006247077.3.
UniGeneiRn.36362.

Genome annotation databases

EnsembliENSRNOT00000012279; ENSRNOP00000012279; ENSRNOG00000008921.
GeneIDi140734.
KEGGirno:140734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034383 mRNA. Translation: AAK57536.1.
BC061874 mRNA. Translation: AAH61874.1.
RefSeqiNP_542428.1. NM_080697.2.
XP_006247139.1. XM_006247077.3.
UniGeneiRn.36362.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWJNMR-A1-89[»]
1PWKNMR-A1-89[»]
ProteinModelPortaliQ78P75.
SMRiQ78P75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250846. 1 interactor.
IntActiQ78P75. 1 interactor.
MINTiMINT-4577592.
STRINGi10116.ENSRNOP00000012279.

PTM databases

iPTMnetiQ78P75.
PhosphoSitePlusiQ78P75.

Proteomic databases

PaxDbiQ78P75.
PRIDEiQ78P75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012279; ENSRNOP00000012279; ENSRNOG00000008921.
GeneIDi140734.
KEGGirno:140734.

Organism-specific databases

CTDi140735.
RGDi619860. Dynll2.

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ78P75.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG091G15JY.
PhylomeDBiQ78P75.
TreeFamiTF300264.

Enzyme and pathway databases

ReactomeiR-RNO-139910. Activation of BMF and translocation to mitochondria.
R-RNO-1632852. Macroautophagy.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-5620924. Intraflagellar transport.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

EvolutionaryTraceiQ78P75.
PROiQ78P75.

Gene expression databases

BgeeiENSRNOG00000008921.
GenevisibleiQ78P75. RN.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYL2_RAT
AccessioniPrimary (citable) accession number: Q78P75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

As DLC8 is commonly used to refer to both DLC1 and DLC2 proteins, it is preferable to adopt the following nomenclature (see PubMed:11602781) where DLC8a and DLC8b corresponds respectively to DLC1 and DLC2.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.