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Protein

Dynein light chain 2, cytoplasmic

Gene

Dynll2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-139910. Activation of BMF and translocation to mitochondria.
R-RNO-141444. Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
R-RNO-1632852. Macroautophagy.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.
R-RNO-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-RNO-5620924. Intraflagellar transport.
R-RNO-5663220. RHO GTPases Activate Formins.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-RNO-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 2, cytoplasmic
Alternative name(s):
Dynein light chain LC8-type 2
Gene namesi
Name:Dynll2
Synonyms:Dlc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619860. Dynll2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951341 – 89Dynein light chain 2, cytoplasmicAdd BLAST89

Proteomic databases

PaxDbiQ78P75.
PRIDEiQ78P75.

PTM databases

iPTMnetiQ78P75.
PhosphoSitePlusiQ78P75.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008921.
GenevisibleiQ78P75. RN.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF and GPHN. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41Interaction with myosin V motor complexBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250846. 2 interactors.
IntActiQ78P75. 1 interactor.
MINTiMINT-4577592.
STRINGi10116.ENSRNOP00000012279.

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi16 – 31Combined sources16
Helixi36 – 50Combined sources15
Beta strandi57 – 61Combined sources5
Beta strandi64 – 66Combined sources3
Turni67 – 69Combined sources3
Beta strandi71 – 78Combined sources8
Beta strandi81 – 87Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWJNMR-A1-89[»]
1PWKNMR-A1-89[»]
ProteinModelPortaliQ78P75.
SMRiQ78P75.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ78P75.

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiQ78P75.
KOiK10418.
OMAiKGPTWHC.
OrthoDBiEOG091G15JY.
PhylomeDBiQ78P75.
TreeFamiTF300264.

Family and domain databases

InterProiView protein in InterPro
IPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiView protein in Pfam
PF01221. Dynein_light. 1 hit.
SMARTiView protein in SMART
SM01375. Dynein_light. 1 hit.
PROSITEiView protein in PROSITE
PS01239. DYNEIN_LIGHT_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q78P75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,350
Last modified:July 5, 2004 - v1
Checksum:i45364D32C0077F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034383 mRNA. Translation: AAK57536.1.
BC061874 mRNA. Translation: AAH61874.1.
RefSeqiNP_542428.1. NM_080697.2.
XP_006247139.1. XM_006247077.3.
UniGeneiRn.36362.

Genome annotation databases

EnsembliENSRNOT00000012279; ENSRNOP00000012279; ENSRNOG00000008921.
GeneIDi140734.
KEGGirno:140734.

Similar proteinsi

Entry informationi

Entry nameiDYL2_RAT
AccessioniPrimary (citable) accession number: Q78P75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

As DLC8 is commonly used to refer to both DLC1 and DLC2 proteins, it is preferable to adopt the following nomenclature (see PubMed:11602781) where DLC8a and DLC8b corresponds respectively to DLC1 and DLC2.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families