Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q78KK3

- S22AI_MOUSE

UniProt

Q78KK3 - S22AI_MOUSE

Protein

Solute carrier family 22 member 18

Gene

Slc22a18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney By similarity.By similarity

    GO - Molecular functioni

    1. drug transmembrane transporter activity Source: Ensembl
    2. organic anion transmembrane transporter activity Source: MGI
    3. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. anion transport Source: MGI
    2. organic anion transport Source: GOC

    Keywords - Biological processi

    Ion transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198610. Organic cation transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 18
    Alternative name(s):
    Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
    Short name:
    Multi-membrane-spanning polyspecific transporter
    Organic cation transporter-like protein 2
    Short name:
    ORCTL-2
    Gene namesi
    Name:Slc22a18
    Synonyms:Impt1, Itm, Orctl2, Tssc5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1336884. Slc22a18.

    Subcellular locationi

    Apical cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localized at the apical membrane surface of renal proximal tubules.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. cytoplasm Source: Ensembl
    3. integral component of plasma membrane Source: MGI
    4. nuclear envelope Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Solute carrier family 22 member 18PRO_0000220510Add
    BLAST

    Proteomic databases

    PaxDbiQ78KK3.
    PRIDEiQ78KK3.

    PTM databases

    PhosphoSiteiQ78KK3.

    Expressioni

    Tissue specificityi

    Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis.3 Publications

    Gene expression databases

    ArrayExpressiQ78KK3.
    BgeeiQ78KK3.
    GenevestigatoriQ78KK3.

    Interactioni

    Subunit structurei

    Interacts with RNF167.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000056082.

    Structurei

    3D structure databases

    ProteinModelPortaliQ78KK3.
    SMRiQ78KK3. Positions 30-80.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG128168.
    GeneTreeiENSGT00700000104523.
    HOGENOMiHOG000068014.
    HOVERGENiHBG082086.
    InParanoidiQ78KK3.
    KOiK08214.
    OrthoDBiEOG747PJ1.
    PhylomeDBiQ78KK3.
    TreeFamiTF352510.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR001958. Tet-R_TetA/multi-R_MdtG.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    PRINTSiPR01035. TCRTETA.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q78KK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALPRQGII ILTYVLAALE LTCLFMQFSI LPYLSRTLGL DSVSFGYLQT    50
    TFGVLQLLGG PVFGRFADQC GARAALSLSF LAASALYLLL VASCSPALPG 100
    VFLLFASRIP SALMHTLPAA QMVITDLTAP TERPAALGRL GLCFGIGIIF 150
    GSLLGGTLNT AYGIQCPAIL AFVVTLLGAV LSFTCVPATT KEASVQSAPQ 200
    GGTKASVFDL KAITRLLLLP RVLPVFLVKV ISGLPSGLFL VMFSIISMDF 250
    FQLEAAQAGY LMSFFGILQM MIQGLVIGRL STHFPEEALL RSSVLVFAVV 300
    GLGMALMSSV LHFCFLMPGL VFSLCTLNVV TDSMLTKAVS ASDTGTMLGL 350
    SASVQPLTRT LGPTLGGLLY RSYGVPIFGH VQLMVNLLVL LVLWKKPLSQ 400
    KGEKAR 406
    Length:406
    Mass (Da):43,013
    Last modified:December 6, 2005 - v2
    Checksum:i034D8223CEB8013C
    GO

    Sequence cautioni

    The sequence AAC04788.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH03734.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331Y → V in CAC16401. (PubMed:11063728)Curated
    Sequence conflicti66 – 661F → Y in CAC16401. (PubMed:11063728)Curated
    Sequence conflicti68 – 681D → N in AAC04788. (PubMed:9570947)Curated
    Sequence conflicti83 – 831A → G in AAB82728. (PubMed:9499412)Curated
    Sequence conflicti117 – 1171L → I in AAC04788. (PubMed:9570947)Curated
    Sequence conflicti119 – 1202AA → GT in CAC16401. (PubMed:11063728)Curated
    Sequence conflicti149 – 1491I → M in AAC04788. (PubMed:9570947)Curated
    Sequence conflicti164 – 1641I → Y in CAC16401. (PubMed:11063728)Curated
    Sequence conflicti178 – 1781G → R in AAB82728. (PubMed:9499412)Curated
    Sequence conflicti205 – 2051A → G in AAB82728. (PubMed:9499412)Curated
    Sequence conflicti228 – 2314VKVI → SVF in AAC04788. (PubMed:9570947)Curated
    Sequence conflicti238 – 2381L → V in CAC16401. (PubMed:11063728)Curated
    Sequence conflicti271 – 2711M → V in CAC16401. (PubMed:11063728)Curated
    Sequence conflicti305 – 3051A → V in CAC16401. (PubMed:11063728)Curated
    Sequence conflicti346 – 3461T → A in CAC16401. (PubMed:11063728)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012084 mRNA. Translation: BAA32780.1.
    AF037065 mRNA. Translation: AAC04788.1. Different initiation.
    AF028739 mRNA. Translation: AAB82728.1.
    AJ276505 Genomic DNA. Translation: CAC16401.2.
    BC003734 mRNA. Translation: AAH03734.2. Different initiation.
    RefSeqiNP_001036225.1. NM_001042760.1.
    NP_032793.2. NM_008767.2.
    UniGeneiMm.271740.

    Genome annotation databases

    EnsembliENSMUST00000052348; ENSMUSP00000056082; ENSMUSG00000000154.
    ENSMUST00000105917; ENSMUSP00000101537; ENSMUSG00000000154.
    GeneIDi18400.
    KEGGimmu:18400.
    UCSCiuc009kpg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012084 mRNA. Translation: BAA32780.1 .
    AF037065 mRNA. Translation: AAC04788.1 . Different initiation.
    AF028739 mRNA. Translation: AAB82728.1 .
    AJ276505 Genomic DNA. Translation: CAC16401.2 .
    BC003734 mRNA. Translation: AAH03734.2 . Different initiation.
    RefSeqi NP_001036225.1. NM_001042760.1.
    NP_032793.2. NM_008767.2.
    UniGenei Mm.271740.

    3D structure databases

    ProteinModelPortali Q78KK3.
    SMRi Q78KK3. Positions 30-80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000056082.

    PTM databases

    PhosphoSitei Q78KK3.

    Proteomic databases

    PaxDbi Q78KK3.
    PRIDEi Q78KK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052348 ; ENSMUSP00000056082 ; ENSMUSG00000000154 .
    ENSMUST00000105917 ; ENSMUSP00000101537 ; ENSMUSG00000000154 .
    GeneIDi 18400.
    KEGGi mmu:18400.
    UCSCi uc009kpg.1. mouse.

    Organism-specific databases

    CTDi 5002.
    MGIi MGI:1336884. Slc22a18.

    Phylogenomic databases

    eggNOGi NOG128168.
    GeneTreei ENSGT00700000104523.
    HOGENOMi HOG000068014.
    HOVERGENi HBG082086.
    InParanoidi Q78KK3.
    KOi K08214.
    OrthoDBi EOG747PJ1.
    PhylomeDBi Q78KK3.
    TreeFami TF352510.

    Enzyme and pathway databases

    Reactomei REACT_198610. Organic cation transport.

    Miscellaneous databases

    NextBioi 294012.
    PROi Q78KK3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q78KK3.
    Bgeei Q78KK3.
    Genevestigatori Q78KK3.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR001958. Tet-R_TetA/multi-R_MdtG.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01035. TCRTETA.
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice."
      Morisaki H., Hatada I., Morisaki T., Mukai T.
      DNA Res. 5:235-240(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain."
      Cooper P.R., Smilinich N.J., Day C.D., Nowak N.J., Reid L.H., Pearsall R.S., Reece M., Prawitt D., Landers J., Housman D.E., Winterpacht A., Zabel B.U., Pelletier J., Weissman B.E., Shows T.B., Higgins M.J.
      Genomics 49:38-51(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes."
      Dao D., Frank D., Qian N., O'Keefe D., Vosatka R.J., Walsh C.P., Tycko B.
      Hum. Mol. Genet. 7:597-608(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    4. "Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting."
      Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R., Lane N., Reik W., Walter J.
      Hum. Mol. Genet. 9:2691-2706(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiS22AI_MOUSE
    AccessioniPrimary (citable) accession number: Q78KK3
    Secondary accession number(s): O35428
    , O54959, O88283, Q99NF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3