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Q78KK3 (S22AI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 18
Alternative name(s):
Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
Short name=Multi-membrane-spanning polyspecific transporter
Organic cation transporter-like protein 2
Short name=ORCTL-2
Gene names
Name:Slc22a18
Synonyms:Impt1, Itm, Orctl2, Tssc5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney By similarity.

Subunit structure

Interacts with RNF167 By similarity.

Subcellular location

Apical cell membrane; Multi-pass membrane protein By similarity. Note: Localized at the apical membrane surface of renal proximal tubules By similarity.

Tissue specificity

Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis. Ref.1 Ref.2 Ref.3

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Sequence caution

The sequence AAC04788.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH03734.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Solute carrier family 22 member 18
PRO_0000220510

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane295 – 31521Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane374 – 39421Helical; Potential

Experimental info

Sequence conflict331Y → V in CAC16401. Ref.4
Sequence conflict661F → Y in CAC16401. Ref.4
Sequence conflict681D → N in AAC04788. Ref.2
Sequence conflict831A → G in AAB82728. Ref.3
Sequence conflict1171L → I in AAC04788. Ref.2
Sequence conflict119 – 1202AA → GT in CAC16401. Ref.4
Sequence conflict1491I → M in AAC04788. Ref.2
Sequence conflict1641I → Y in CAC16401. Ref.4
Sequence conflict1781G → R in AAB82728. Ref.3
Sequence conflict2051A → G in AAB82728. Ref.3
Sequence conflict228 – 2314VKVI → SVF in AAC04788. Ref.2
Sequence conflict2381L → V in CAC16401. Ref.4
Sequence conflict2711M → V in CAC16401. Ref.4
Sequence conflict3051A → V in CAC16401. Ref.4
Sequence conflict3461T → A in CAC16401. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q78KK3 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 034D8223CEB8013C

FASTA40643,013
        10         20         30         40         50         60 
MAALPRQGII ILTYVLAALE LTCLFMQFSI LPYLSRTLGL DSVSFGYLQT TFGVLQLLGG 

        70         80         90        100        110        120 
PVFGRFADQC GARAALSLSF LAASALYLLL VASCSPALPG VFLLFASRIP SALMHTLPAA 

       130        140        150        160        170        180 
QMVITDLTAP TERPAALGRL GLCFGIGIIF GSLLGGTLNT AYGIQCPAIL AFVVTLLGAV 

       190        200        210        220        230        240 
LSFTCVPATT KEASVQSAPQ GGTKASVFDL KAITRLLLLP RVLPVFLVKV ISGLPSGLFL 

       250        260        270        280        290        300 
VMFSIISMDF FQLEAAQAGY LMSFFGILQM MIQGLVIGRL STHFPEEALL RSSVLVFAVV 

       310        320        330        340        350        360 
GLGMALMSSV LHFCFLMPGL VFSLCTLNVV TDSMLTKAVS ASDTGTMLGL SASVQPLTRT 

       370        380        390        400 
LGPTLGGLLY RSYGVPIFGH VQLMVNLLVL LVLWKKPLSQ KGEKAR 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice."
Morisaki H., Hatada I., Morisaki T., Mukai T.
DNA Res. 5:235-240(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain."
Cooper P.R., Smilinich N.J., Day C.D., Nowak N.J., Reid L.H., Pearsall R.S., Reece M., Prawitt D., Landers J., Housman D.E., Winterpacht A., Zabel B.U., Pelletier J., Weissman B.E., Shows T.B., Higgins M.J.
Genomics 49:38-51(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes."
Dao D., Frank D., Qian N., O'Keefe D., Vosatka R.J., Walsh C.P., Tycko B.
Hum. Mol. Genet. 7:597-608(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[4]"Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting."
Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R., Lane N., Reik W., Walter J.
Hum. Mol. Genet. 9:2691-2706(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB012084 mRNA. Translation: BAA32780.1.
AF037065 mRNA. Translation: AAC04788.1. Different initiation.
AF028739 mRNA. Translation: AAB82728.1.
AJ276505 Genomic DNA. Translation: CAC16401.2.
BC003734 mRNA. Translation: AAH03734.2. Different initiation.
RefSeqNP_001036225.1. NM_001042760.1.
NP_032793.2. NM_008767.2.
UniGeneMm.271740.

3D structure databases

ProteinModelPortalQ78KK3.
SMRQ78KK3. Positions 30-80.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000056082.

PTM databases

PhosphoSiteQ78KK3.

Proteomic databases

PaxDbQ78KK3.
PRIDEQ78KK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052348; ENSMUSP00000056082; ENSMUSG00000000154.
ENSMUST00000105917; ENSMUSP00000101537; ENSMUSG00000000154.
GeneID18400.
KEGGmmu:18400.
UCSCuc009kpg.1. mouse.

Organism-specific databases

CTD5002.
MGIMGI:1336884. Slc22a18.

Phylogenomic databases

eggNOGNOG128168.
GeneTreeENSGT00700000104523.
HOGENOMHOG000068014.
HOVERGENHBG082086.
InParanoidQ78KK3.
KOK08214.
OrthoDBEOG747PJ1.
PhylomeDBQ78KK3.
TreeFamTF352510.

Gene expression databases

ArrayExpressQ78KK3.
BgeeQ78KK3.
GenevestigatorQ78KK3.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSPR01035. TCRTETA.
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294012.
PROQ78KK3.
SOURCESearch...

Entry information

Entry nameS22AI_MOUSE
AccessionPrimary (citable) accession number: Q78KK3
Secondary accession number(s): O35428 expand/collapse secondary AC list , O54959, O88283, Q99NF4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 11, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot