Solute carrier family 22 member 18 - Mus musculus (Mouse)

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Q78KK3 (S22AI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Solute carrier family 22 member 18

Alternative name(s):
Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
Short name=Multi-membrane-spanning polyspecific transporter
Organic cation transporter-like protein 2
Short name=ORCTL-2

Gene names

Name:	Slc22a18
Synonyms:	Impt1, Itm, Orctl2, Tssc5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney By similarity.
Subunit structure	Interacts with RNF167 By similarity.
Subcellular location	Apical cell membrane; Multi-pass membrane protein By similarity. Note: Localized at the apical membrane surface of renal proximal tubules By similarity.
Tissue specificity	Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis. Ref.1 Ref.2 Ref.3
Sequence similarities	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]
Sequence caution	The sequence AAC04788.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH03734.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Symport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic part Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from sequence or structural similarity PubMed 10751225. Source: MGI nuclear envelope Inferred from electronic annotation. Source: Compara
Molecular_function	drug transmembrane transporter activity Inferred from electronic annotation. Source: Compara organic anion transmembrane transporter activity Traceable author statement PubMed 10751225. Source: MGI symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 406

406

Solute carrier family 22 member 18

PRO_0000220510

Regions

Transmembrane

8 – 28

Helical; Potential

Transmembrane

43 – 63

Helical; Potential

Transmembrane

85 – 105

Helical; Potential

Transmembrane

140 – 160

Helical; Potential

Transmembrane

168 – 188

Helical; Potential

Transmembrane

226 – 246

Helical; Potential

Transmembrane

258 – 278

Helical; Potential

Transmembrane

295 – 315

Helical; Potential

Transmembrane

316 – 336

Helical; Potential

Transmembrane

374 – 394

Helical; Potential

Experimental info

Sequence conflict

Y → V in CAC16401. Ref.4

Sequence conflict

F → Y in CAC16401. Ref.4

Sequence conflict

D → N in AAC04788. Ref.2

Sequence conflict

A → G in AAB82728. Ref.3

Sequence conflict

117

L → I in AAC04788. Ref.2

Sequence conflict

119 – 120

AA → GT in CAC16401. Ref.4

Sequence conflict

149

I → M in AAC04788. Ref.2

Sequence conflict

164

I → Y in CAC16401. Ref.4

Sequence conflict

178

G → R in AAB82728. Ref.3

Sequence conflict

205

A → G in AAB82728. Ref.3

Sequence conflict

228 – 231

VKVI → SVF in AAC04788. Ref.2

Sequence conflict

238

L → V in CAC16401. Ref.4

Sequence conflict

271

M → V in CAC16401. Ref.4

Sequence conflict

305

A → V in CAC16401. Ref.4

Sequence conflict

346

T → A in CAC16401. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q78KK3 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 034D8223CEB8013C
Show »

FASTA

406

43,013

        10         20         30         40         50         60 
MAALPRQGII ILTYVLAALE LTCLFMQFSI LPYLSRTLGL DSVSFGYLQT TFGVLQLLGG 

        70         80         90        100        110        120 
PVFGRFADQC GARAALSLSF LAASALYLLL VASCSPALPG VFLLFASRIP SALMHTLPAA 

       130        140        150        160        170        180 
QMVITDLTAP TERPAALGRL GLCFGIGIIF GSLLGGTLNT AYGIQCPAIL AFVVTLLGAV 

       190        200        210        220        230        240 
LSFTCVPATT KEASVQSAPQ GGTKASVFDL KAITRLLLLP RVLPVFLVKV ISGLPSGLFL 

       250        260        270        280        290        300 
VMFSIISMDF FQLEAAQAGY LMSFFGILQM MIQGLVIGRL STHFPEEALL RSSVLVFAVV 

       310        320        330        340        350        360 
GLGMALMSSV LHFCFLMPGL VFSLCTLNVV TDSMLTKAVS ASDTGTMLGL SASVQPLTRT 

       370        380        390        400 
LGPTLGGLLY RSYGVPIFGH VQLMVNLLVL LVLWKKPLSQ KGEKAR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice." Morisaki H., Hatada I., Morisaki T., Mukai T. DNA Res. 5:235-240(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain." Cooper P.R., Smilinich N.J., Day C.D., Nowak N.J., Reid L.H., Pearsall R.S., Reece M., Prawitt D., Landers J., Housman D.E., Winterpacht A., Zabel B.U., Pelletier J., Weissman B.E., Shows T.B., Higgins M.J. Genomics 49:38-51(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes." Dao D., Frank D., Qian N., O'Keefe D., Vosatka R.J., Walsh C.P., Tycko B. Hum. Mol. Genet. 7:597-608(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[4]	"Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting." Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R., Lane N., Reik W., Walter J. Hum. Mol. Genet. 9:2691-2706(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012084 mRNA. Translation: BAA32780.1. AF037065 mRNA. Translation: AAC04788.1. Different initiation. AF028739 mRNA. Translation: AAB82728.1. AJ276505 Genomic DNA. Translation: CAC16401.2. BC003734 mRNA. Translation: AAH03734.2. Different initiation.
IPI	IPI00310201.
RefSeq	NP_001036225.1. NM_001042760.1. NP_032793.2. NM_008767.2.
UniGene	Mm.271740.
3D structure databases
ProteinModelPortal	Q78KK3.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000056082.
PTM databases
PhosphoSite	Q78KK3.
Proteomic databases
PaxDb	Q78KK3.
PRIDE	Q78KK3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000052348; ENSMUSP00000056082; ENSMUSG00000000154. ENSMUST00000105917; ENSMUSP00000101537; ENSMUSG00000000154.
GeneID	18400.
KEGG	mmu:18400.
UCSC	uc009kpg.1. mouse.
Organism-specific databases
CTD	5002.
MGI	MGI:1336884. Slc22a18.
Phylogenomic databases
eggNOG	NOG128168.
GeneTree	ENSGT00700000104523.
HOGENOM	HOG000068014.
HOVERGEN	HBG082086.
InParanoid	Q78KK3.
KO	K08214.
OrthoDB	EOG4QZ7M5.
Gene expression databases
ArrayExpress	Q78KK3.
Bgee	Q78KK3.
Genevestigator	Q78KK3.
GermOnline	ENSMUSG00000000154. Mus musculus.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR001958. Tet-R_TetA/multi-R_MdtG. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
PRINTS	PR01035. TCRTETA.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294012.
SOURCE	Search...

Entry information

Entry name

S22AI_MOUSE

Accession

Primary (citable) accession number: Q78KK3
Secondary accession number(s): O35428

Q99NF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents