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Q78KK3

- S22AI_MOUSE

UniProt

Q78KK3 - S22AI_MOUSE

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Protein

Solute carrier family 22 member 18

Gene
Slc22a18, Impt1, Itm, Orctl2, Tssc5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney By similarity.

GO - Molecular functioni

  1. drug transmembrane transporter activity Source: Ensembl
  2. organic anion transmembrane transporter activity Source: MGI
  3. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. anion transport Source: MGI
  2. organic anion transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_198610. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 18
Alternative name(s):
Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
Short name:
Multi-membrane-spanning polyspecific transporter
Organic cation transporter-like protein 2
Short name:
ORCTL-2
Gene namesi
Name:Slc22a18
Synonyms:Impt1, Itm, Orctl2, Tssc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1336884. Slc22a18.

Subcellular locationi

Apical cell membrane; Multi-pass membrane protein By similarity
Note: Localized at the apical membrane surface of renal proximal tubules By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei43 – 6321Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Reviewed predictionAdd
BLAST
Transmembranei168 – 18821Helical; Reviewed predictionAdd
BLAST
Transmembranei226 – 24621Helical; Reviewed predictionAdd
BLAST
Transmembranei258 – 27821Helical; Reviewed predictionAdd
BLAST
Transmembranei295 – 31521Helical; Reviewed predictionAdd
BLAST
Transmembranei316 – 33621Helical; Reviewed predictionAdd
BLAST
Transmembranei374 – 39421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. cytoplasm Source: Ensembl
  3. integral component of plasma membrane Source: MGI
  4. nuclear envelope Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Solute carrier family 22 member 18PRO_0000220510Add
BLAST

Proteomic databases

PaxDbiQ78KK3.
PRIDEiQ78KK3.

PTM databases

PhosphoSiteiQ78KK3.

Expressioni

Tissue specificityi

Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis.3 Publications

Gene expression databases

ArrayExpressiQ78KK3.
BgeeiQ78KK3.
GenevestigatoriQ78KK3.

Interactioni

Subunit structurei

Interacts with RNF167 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056082.

Structurei

3D structure databases

ProteinModelPortaliQ78KK3.
SMRiQ78KK3. Positions 30-80.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG128168.
GeneTreeiENSGT00700000104523.
HOGENOMiHOG000068014.
HOVERGENiHBG082086.
InParanoidiQ78KK3.
KOiK08214.
OrthoDBiEOG747PJ1.
PhylomeDBiQ78KK3.
TreeFamiTF352510.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q78KK3-1 [UniParc]FASTAAdd to Basket

« Hide

MAALPRQGII ILTYVLAALE LTCLFMQFSI LPYLSRTLGL DSVSFGYLQT    50
TFGVLQLLGG PVFGRFADQC GARAALSLSF LAASALYLLL VASCSPALPG 100
VFLLFASRIP SALMHTLPAA QMVITDLTAP TERPAALGRL GLCFGIGIIF 150
GSLLGGTLNT AYGIQCPAIL AFVVTLLGAV LSFTCVPATT KEASVQSAPQ 200
GGTKASVFDL KAITRLLLLP RVLPVFLVKV ISGLPSGLFL VMFSIISMDF 250
FQLEAAQAGY LMSFFGILQM MIQGLVIGRL STHFPEEALL RSSVLVFAVV 300
GLGMALMSSV LHFCFLMPGL VFSLCTLNVV TDSMLTKAVS ASDTGTMLGL 350
SASVQPLTRT LGPTLGGLLY RSYGVPIFGH VQLMVNLLVL LVLWKKPLSQ 400
KGEKAR 406
Length:406
Mass (Da):43,013
Last modified:December 6, 2005 - v2
Checksum:i034D8223CEB8013C
GO

Sequence cautioni

The sequence AAC04788.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH03734.2 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331Y → V in CAC16401. 1 Publication
Sequence conflicti66 – 661F → Y in CAC16401. 1 Publication
Sequence conflicti68 – 681D → N in AAC04788. 1 Publication
Sequence conflicti83 – 831A → G in AAB82728. 1 Publication
Sequence conflicti117 – 1171L → I in AAC04788. 1 Publication
Sequence conflicti119 – 1202AA → GT in CAC16401. 1 Publication
Sequence conflicti149 – 1491I → M in AAC04788. 1 Publication
Sequence conflicti164 – 1641I → Y in CAC16401. 1 Publication
Sequence conflicti178 – 1781G → R in AAB82728. 1 Publication
Sequence conflicti205 – 2051A → G in AAB82728. 1 Publication
Sequence conflicti228 – 2314VKVI → SVF in AAC04788. 1 Publication
Sequence conflicti238 – 2381L → V in CAC16401. 1 Publication
Sequence conflicti271 – 2711M → V in CAC16401. 1 Publication
Sequence conflicti305 – 3051A → V in CAC16401. 1 Publication
Sequence conflicti346 – 3461T → A in CAC16401. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012084 mRNA. Translation: BAA32780.1.
AF037065 mRNA. Translation: AAC04788.1. Different initiation.
AF028739 mRNA. Translation: AAB82728.1.
AJ276505 Genomic DNA. Translation: CAC16401.2.
BC003734 mRNA. Translation: AAH03734.2. Different initiation.
RefSeqiNP_001036225.1. NM_001042760.1.
NP_032793.2. NM_008767.2.
UniGeneiMm.271740.

Genome annotation databases

EnsembliENSMUST00000052348; ENSMUSP00000056082; ENSMUSG00000000154.
ENSMUST00000105917; ENSMUSP00000101537; ENSMUSG00000000154.
GeneIDi18400.
KEGGimmu:18400.
UCSCiuc009kpg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012084 mRNA. Translation: BAA32780.1 .
AF037065 mRNA. Translation: AAC04788.1 . Different initiation.
AF028739 mRNA. Translation: AAB82728.1 .
AJ276505 Genomic DNA. Translation: CAC16401.2 .
BC003734 mRNA. Translation: AAH03734.2 . Different initiation.
RefSeqi NP_001036225.1. NM_001042760.1.
NP_032793.2. NM_008767.2.
UniGenei Mm.271740.

3D structure databases

ProteinModelPortali Q78KK3.
SMRi Q78KK3. Positions 30-80.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000056082.

PTM databases

PhosphoSitei Q78KK3.

Proteomic databases

PaxDbi Q78KK3.
PRIDEi Q78KK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052348 ; ENSMUSP00000056082 ; ENSMUSG00000000154 .
ENSMUST00000105917 ; ENSMUSP00000101537 ; ENSMUSG00000000154 .
GeneIDi 18400.
KEGGi mmu:18400.
UCSCi uc009kpg.1. mouse.

Organism-specific databases

CTDi 5002.
MGIi MGI:1336884. Slc22a18.

Phylogenomic databases

eggNOGi NOG128168.
GeneTreei ENSGT00700000104523.
HOGENOMi HOG000068014.
HOVERGENi HBG082086.
InParanoidi Q78KK3.
KOi K08214.
OrthoDBi EOG747PJ1.
PhylomeDBi Q78KK3.
TreeFami TF352510.

Enzyme and pathway databases

Reactomei REACT_198610. Organic cation transport.

Miscellaneous databases

NextBioi 294012.
PROi Q78KK3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q78KK3.
Bgeei Q78KK3.
Genevestigatori Q78KK3.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
PRINTSi PR01035. TCRTETA.
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice."
    Morisaki H., Hatada I., Morisaki T., Mukai T.
    DNA Res. 5:235-240(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain."
    Cooper P.R., Smilinich N.J., Day C.D., Nowak N.J., Reid L.H., Pearsall R.S., Reece M., Prawitt D., Landers J., Housman D.E., Winterpacht A., Zabel B.U., Pelletier J., Weissman B.E., Shows T.B., Higgins M.J.
    Genomics 49:38-51(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes."
    Dao D., Frank D., Qian N., O'Keefe D., Vosatka R.J., Walsh C.P., Tycko B.
    Hum. Mol. Genet. 7:597-608(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  4. "Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting."
    Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R., Lane N., Reik W., Walter J.
    Hum. Mol. Genet. 9:2691-2706(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS22AI_MOUSE
AccessioniPrimary (citable) accession number: Q78KK3
Secondary accession number(s): O35428
, O54959, O88283, Q99NF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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