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Protein

Solute carrier family 22 member 18

Gene

Slc22a18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: MGI
  • drug transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 18
Alternative name(s):
Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
Short name:
Multi-membrane-spanning polyspecific transporter
Organic cation transporter-like protein 2
Short name:
ORCTL-2
Gene namesi
Name:Slc22a18
Synonyms:Impt1, Itm, Orctl2, Tssc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1336884. Slc22a18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • cytoplasm Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
  • nuclear envelope Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205101 – 406Solute carrier family 22 member 18Add BLAST406

Proteomic databases

PaxDbiQ78KK3.
PRIDEiQ78KK3.

PTM databases

iPTMnetiQ78KK3.
PhosphoSitePlusiQ78KK3.

Expressioni

Tissue specificityi

Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis.3 Publications

Gene expression databases

BgeeiENSMUSG00000000154.

Interactioni

Subunit structurei

Interacts with RNF167.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056082.

Structurei

3D structure databases

ProteinModelPortaliQ78KK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIP5. Eukaryota.
ENOG4111F2C. LUCA.
HOGENOMiHOG000068014.
HOVERGENiHBG082086.
InParanoidiQ78KK3.
KOiK08214.
PhylomeDBiQ78KK3.
TreeFamiTF352510.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q78KK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALPRQGII ILTYVLAALE LTCLFMQFSI LPYLSRTLGL DSVSFGYLQT
60 70 80 90 100
TFGVLQLLGG PVFGRFADQC GARAALSLSF LAASALYLLL VASCSPALPG
110 120 130 140 150
VFLLFASRIP SALMHTLPAA QMVITDLTAP TERPAALGRL GLCFGIGIIF
160 170 180 190 200
GSLLGGTLNT AYGIQCPAIL AFVVTLLGAV LSFTCVPATT KEASVQSAPQ
210 220 230 240 250
GGTKASVFDL KAITRLLLLP RVLPVFLVKV ISGLPSGLFL VMFSIISMDF
260 270 280 290 300
FQLEAAQAGY LMSFFGILQM MIQGLVIGRL STHFPEEALL RSSVLVFAVV
310 320 330 340 350
GLGMALMSSV LHFCFLMPGL VFSLCTLNVV TDSMLTKAVS ASDTGTMLGL
360 370 380 390 400
SASVQPLTRT LGPTLGGLLY RSYGVPIFGH VQLMVNLLVL LVLWKKPLSQ

KGEKAR
Length:406
Mass (Da):43,013
Last modified:December 6, 2005 - v2
Checksum:i034D8223CEB8013C
GO

Sequence cautioni

The sequence AAC04788 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH03734 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33Y → V in CAC16401 (PubMed:11063728).Curated1
Sequence conflicti66F → Y in CAC16401 (PubMed:11063728).Curated1
Sequence conflicti68D → N in AAC04788 (PubMed:9570947).Curated1
Sequence conflicti83A → G in AAB82728 (PubMed:9499412).Curated1
Sequence conflicti117L → I in AAC04788 (PubMed:9570947).Curated1
Sequence conflicti119 – 120AA → GT in CAC16401 (PubMed:11063728).Curated2
Sequence conflicti149I → M in AAC04788 (PubMed:9570947).Curated1
Sequence conflicti164I → Y in CAC16401 (PubMed:11063728).Curated1
Sequence conflicti178G → R in AAB82728 (PubMed:9499412).Curated1
Sequence conflicti205A → G in AAB82728 (PubMed:9499412).Curated1
Sequence conflicti228 – 231VKVI → SVF in AAC04788 (PubMed:9570947).Curated4
Sequence conflicti238L → V in CAC16401 (PubMed:11063728).Curated1
Sequence conflicti271M → V in CAC16401 (PubMed:11063728).Curated1
Sequence conflicti305A → V in CAC16401 (PubMed:11063728).Curated1
Sequence conflicti346T → A in CAC16401 (PubMed:11063728).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012084 mRNA. Translation: BAA32780.1.
AF037065 mRNA. Translation: AAC04788.1. Different initiation.
AF028739 mRNA. Translation: AAB82728.1.
AJ276505 Genomic DNA. Translation: CAC16401.2.
BC003734 mRNA. Translation: AAH03734.2. Different initiation.
RefSeqiNP_001036225.1. NM_001042760.1.
NP_032793.2. NM_008767.2.
UniGeneiMm.271740.

Genome annotation databases

GeneIDi18400.
KEGGimmu:18400.
UCSCiuc009kpg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012084 mRNA. Translation: BAA32780.1.
AF037065 mRNA. Translation: AAC04788.1. Different initiation.
AF028739 mRNA. Translation: AAB82728.1.
AJ276505 Genomic DNA. Translation: CAC16401.2.
BC003734 mRNA. Translation: AAH03734.2. Different initiation.
RefSeqiNP_001036225.1. NM_001042760.1.
NP_032793.2. NM_008767.2.
UniGeneiMm.271740.

3D structure databases

ProteinModelPortaliQ78KK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056082.

PTM databases

iPTMnetiQ78KK3.
PhosphoSitePlusiQ78KK3.

Proteomic databases

PaxDbiQ78KK3.
PRIDEiQ78KK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18400.
KEGGimmu:18400.
UCSCiuc009kpg.1. mouse.

Organism-specific databases

CTDi5002.
MGIiMGI:1336884. Slc22a18.

Phylogenomic databases

eggNOGiENOG410IIP5. Eukaryota.
ENOG4111F2C. LUCA.
HOGENOMiHOG000068014.
HOVERGENiHBG082086.
InParanoidiQ78KK3.
KOiK08214.
PhylomeDBiQ78KK3.
TreeFamiTF352510.

Miscellaneous databases

PROiQ78KK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000154.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AI_MOUSE
AccessioniPrimary (citable) accession number: Q78KK3
Secondary accession number(s): O35428
, O54959, O88283, Q99NF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.