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Q78JT3

- 3HAO_MOUSE

UniProt

Q78JT3 - 3HAO_MOUSE

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

Haao

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431DioxygenUniRule annotation
    Metal bindingi47 – 471Iron; catalyticUniRule annotation
    Metal bindingi53 – 531Iron; catalyticUniRule annotation
    Binding sitei53 – 531SubstrateUniRule annotation
    Metal bindingi91 – 911Iron; catalyticUniRule annotation
    Binding sitei95 – 951SubstrateUniRule annotation
    Binding sitei105 – 1051SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: MGI
    2. ferrous iron binding Source: UniProtKB-HAMAP
    3. oxygen binding Source: Ensembl

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. neuron cellular homeostasis Source: Ensembl
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. response to cadmium ion Source: Ensembl
    6. response to zinc ion Source: Ensembl
    7. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Gene namesi
    Name:Haao
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1349444. Haao.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrial membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2862863-hydroxyanthranilate 3,4-dioxygenasePRO_0000064373Add
    BLAST

    Proteomic databases

    MaxQBiQ78JT3.
    PaxDbiQ78JT3.
    PRIDEiQ78JT3.

    PTM databases

    PhosphoSiteiQ78JT3.

    Expressioni

    Gene expression databases

    BgeeiQ78JT3.
    CleanExiMM_HAAO.
    GenevestigatoriQ78JT3.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    MINTiMINT-1868896.

    Structurei

    3D structure databases

    ProteinModelPortaliQ78JT3.
    SMRiQ78JT3. Positions 2-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 160160Domain A (catalytic)UniRule annotationAdd
    BLAST
    Regioni161 – 17717LinkerUniRule annotationAdd
    BLAST
    Regioni178 – 286109Domain BUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG77058.
    GeneTreeiENSGT00390000013008.
    HOGENOMiHOG000218448.
    HOVERGENiHBG000018.
    InParanoidiQ78JT3.
    KOiK00452.
    OMAiDMCLKVI.
    OrthoDBiEOG7FFMS4.
    PhylomeDBiQ78JT3.
    TreeFamiTF300246.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMiSSF51182. SSF51182. 2 hits.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q78JT3-1 [UniParc]FASTAAdd to Basket

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    MERRVRVKSW VEENRASFQP PVCNKLMHQE QLKIMFVGGP NTRKDYHIEE    50
    GEEVFYQLEG DMILRVLEQG QHRDVPIRQG EIFLLPARVP HSPQRFANTM 100
    GLVIERRRLE SELDGLRYYV GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH 150
    SEQYRTGKPN PDQLLKELPF PLNTRSIMKP MSLKAWLDGH SRELQAGTSL 200
    SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQQEGSSKVT MGGQCIALAP 250
    DDSLLVPAGT SYVWERAQGS VALSVTQDPA RKKPWW 286
    Length:286
    Mass (Da):32,804
    Last modified:July 5, 2004 - v1
    Checksum:iCD8A706EE264B4CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012872 mRNA. Translation: AAH12872.1.
    BC094021 mRNA. Translation: AAH94021.1.
    CCDSiCCDS37709.1.
    RefSeqiNP_079601.1. NM_025325.2.
    XP_006523526.1. XM_006523463.1.
    XP_006523527.1. XM_006523464.1.
    UniGeneiMm.30100.

    Genome annotation databases

    EnsembliENSMUST00000000687; ENSMUSP00000000687; ENSMUSG00000000673.
    GeneIDi107766.
    KEGGimmu:107766.
    UCSCiuc008dsk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012872 mRNA. Translation: AAH12872.1 .
    BC094021 mRNA. Translation: AAH94021.1 .
    CCDSi CCDS37709.1.
    RefSeqi NP_079601.1. NM_025325.2.
    XP_006523526.1. XM_006523463.1.
    XP_006523527.1. XM_006523464.1.
    UniGenei Mm.30100.

    3D structure databases

    ProteinModelPortali Q78JT3.
    SMRi Q78JT3. Positions 2-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1868896.

    PTM databases

    PhosphoSitei Q78JT3.

    Proteomic databases

    MaxQBi Q78JT3.
    PaxDbi Q78JT3.
    PRIDEi Q78JT3.

    Protocols and materials databases

    DNASUi 107766.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000687 ; ENSMUSP00000000687 ; ENSMUSG00000000673 .
    GeneIDi 107766.
    KEGGi mmu:107766.
    UCSCi uc008dsk.1. mouse.

    Organism-specific databases

    CTDi 23498.
    MGIi MGI:1349444. Haao.

    Phylogenomic databases

    eggNOGi NOG77058.
    GeneTreei ENSGT00390000013008.
    HOGENOMi HOG000218448.
    HOVERGENi HBG000018.
    InParanoidi Q78JT3.
    KOi K00452.
    OMAi DMCLKVI.
    OrthoDBi EOG7FFMS4.
    PhylomeDBi Q78JT3.
    TreeFami TF300246.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .

    Miscellaneous databases

    NextBioi 359412.
    PROi Q78JT3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q78JT3.
    CleanExi MM_HAAO.
    Genevestigatori Q78JT3.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMi SSF51182. SSF51182. 2 hits.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry namei3HAO_MOUSE
    AccessioniPrimary (citable) accession number: Q78JT3
    Secondary accession number(s): Q52L88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3