Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q78JT3 (3HAO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Name:Haao
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2862863-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000064373

Regions

Region1 – 160160Domain A (catalytic) By similarity
Region161 – 17717Linker By similarity
Region178 – 286109Domain B By similarity

Sites

Metal binding471Iron; catalytic By similarity
Metal binding531Iron; catalytic By similarity
Metal binding911Iron; catalytic By similarity
Binding site431Dioxygen By similarity
Binding site531Substrate By similarity
Binding site951Substrate By similarity
Binding site1051Substrate By similarity

Amino acid modifications

Modified residue91Phosphoserine Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q78JT3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CD8A706EE264B4CD

FASTA28632,804
        10         20         30         40         50         60 
MERRVRVKSW VEENRASFQP PVCNKLMHQE QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 

        70         80         90        100        110        120 
DMILRVLEQG QHRDVPIRQG EIFLLPARVP HSPQRFANTM GLVIERRRLE SELDGLRYYV 

       130        140        150        160        170        180 
GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH SEQYRTGKPN PDQLLKELPF PLNTRSIMKP 

       190        200        210        220        230        240 
MSLKAWLDGH SRELQAGTSL SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQQEGSSKVT 

       250        260        270        280 
MGGQCIALAP DDSLLVPAGT SYVWERAQGS VALSVTQDPA RKKPWW

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[2]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC012872 mRNA. Translation: AAH12872.1.
BC094021 mRNA. Translation: AAH94021.1.
IPIIPI00408961.
RefSeqNP_079601.1. NM_025325.2.
UniGeneMm.30100.

3D structure databases

ProteinModelPortalQ78JT3.
SMRQ78JT3. Positions 2-284.
ModBaseSearch...

PTM databases

PhosphoSiteQ78JT3.

Proteomic databases

PaxDbQ78JT3.
PRIDEQ78JT3.

Protocols and materials databases

DNASU107766.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000687; ENSMUSP00000000687; ENSMUSG00000000673.
GeneID107766.
KEGGmmu:107766.
UCSCuc008dsk.1. mouse.

Organism-specific databases

CTD23498.
MGIMGI:1349444. Haao.

Phylogenomic databases

eggNOGNOG77058.
GeneTreeENSGT00390000013008.
HOGENOMHOG000218448.
HOVERGENHBG000018.
InParanoidQ78JT3.
KOK00452.
OMAYDHISEV.
OrthoDBEOG4F4SBR.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Gene expression databases

BgeeQ78JT3.
CleanExMM_HAAO.
GenevestigatorQ78JT3.
GermOnlineENSMUSG00000000673. Mus musculus.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMSSF51182. RmlC_like_cupin. 2 hits.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Other

NextBio359412.
SOURCESearch...

Entry information

Entry name3HAO_MOUSE
AccessionPrimary (citable) accession number: Q78JT3
Secondary accession number(s): Q52L88
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents