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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

Haao

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431DioxygenUniRule annotation
Metal bindingi47 – 471Iron; catalyticUniRule annotation
Metal bindingi53 – 531Iron; catalyticUniRule annotation
Binding sitei53 – 531SubstrateUniRule annotation
Metal bindingi91 – 911Iron; catalyticUniRule annotation
Binding sitei95 – 951SubstrateUniRule annotation
Binding sitei105 – 1051SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: MGI
  2. ferrous iron binding Source: MGI
  3. oxygen binding Source: Ensembl

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. neuron cellular homeostasis Source: MGI
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. response to cadmium ion Source: MGI
  6. response to zinc ion Source: MGI
  7. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_240936. Tryptophan catabolism.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:Haao
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1349444. Haao.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. mitochondrial membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2862863-hydroxyanthranilate 3,4-dioxygenasePRO_0000064373Add
BLAST

Proteomic databases

MaxQBiQ78JT3.
PaxDbiQ78JT3.
PRIDEiQ78JT3.

PTM databases

PhosphoSiteiQ78JT3.

Expressioni

Gene expression databases

BgeeiQ78JT3.
CleanExiMM_HAAO.
GenevestigatoriQ78JT3.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

MINTiMINT-1868896.

Structurei

3D structure databases

ProteinModelPortaliQ78JT3.
SMRiQ78JT3. Positions 2-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 160160Domain A (catalytic)UniRule annotationAdd
BLAST
Regioni161 – 17717LinkerUniRule annotationAdd
BLAST
Regioni178 – 286109Domain BUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
HOVERGENiHBG000018.
InParanoidiQ78JT3.
KOiK00452.
OMAiERWFYCE.
OrthoDBiEOG7FFMS4.
PhylomeDBiQ78JT3.
TreeFamiTF300246.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 2 hits.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q78JT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERRVRVKSW VEENRASFQP PVCNKLMHQE QLKIMFVGGP NTRKDYHIEE
60 70 80 90 100
GEEVFYQLEG DMILRVLEQG QHRDVPIRQG EIFLLPARVP HSPQRFANTM
110 120 130 140 150
GLVIERRRLE SELDGLRYYV GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH
160 170 180 190 200
SEQYRTGKPN PDQLLKELPF PLNTRSIMKP MSLKAWLDGH SRELQAGTSL
210 220 230 240 250
SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQQEGSSKVT MGGQCIALAP
260 270 280
DDSLLVPAGT SYVWERAQGS VALSVTQDPA RKKPWW
Length:286
Mass (Da):32,804
Last modified:July 5, 2004 - v1
Checksum:iCD8A706EE264B4CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012872 mRNA. Translation: AAH12872.1.
BC094021 mRNA. Translation: AAH94021.1.
CCDSiCCDS37709.1.
RefSeqiNP_079601.1. NM_025325.2.
XP_006523526.1. XM_006523463.1.
XP_006523527.1. XM_006523464.1.
UniGeneiMm.30100.

Genome annotation databases

EnsembliENSMUST00000000687; ENSMUSP00000000687; ENSMUSG00000000673.
GeneIDi107766.
KEGGimmu:107766.
UCSCiuc008dsk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012872 mRNA. Translation: AAH12872.1.
BC094021 mRNA. Translation: AAH94021.1.
CCDSiCCDS37709.1.
RefSeqiNP_079601.1. NM_025325.2.
XP_006523526.1. XM_006523463.1.
XP_006523527.1. XM_006523464.1.
UniGeneiMm.30100.

3D structure databases

ProteinModelPortaliQ78JT3.
SMRiQ78JT3. Positions 2-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1868896.

PTM databases

PhosphoSiteiQ78JT3.

Proteomic databases

MaxQBiQ78JT3.
PaxDbiQ78JT3.
PRIDEiQ78JT3.

Protocols and materials databases

DNASUi107766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000687; ENSMUSP00000000687; ENSMUSG00000000673.
GeneIDi107766.
KEGGimmu:107766.
UCSCiuc008dsk.1. mouse.

Organism-specific databases

CTDi23498.
MGIiMGI:1349444. Haao.

Phylogenomic databases

eggNOGiNOG77058.
GeneTreeiENSGT00390000013008.
HOGENOMiHOG000218448.
HOVERGENiHBG000018.
InParanoidiQ78JT3.
KOiK00452.
OMAiERWFYCE.
OrthoDBiEOG7FFMS4.
PhylomeDBiQ78JT3.
TreeFamiTF300246.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.
ReactomeiREACT_240936. Tryptophan catabolism.

Miscellaneous databases

NextBioi359412.
PROiQ78JT3.
SOURCEiSearch...

Gene expression databases

BgeeiQ78JT3.
CleanExiMM_HAAO.
GenevestigatoriQ78JT3.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 2 hits.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry namei3HAO_MOUSE
AccessioniPrimary (citable) accession number: Q78JT3
Secondary accession number(s): Q52L88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.