Reviewed, UniProtKB/Swiss-Prot Q78JT3 (3HAO_MOUSE)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

Name:

Haao

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the synthesis of the excitotoxin quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. The direct product of the reaction spontaneously rearranges to QUIN By similarity.
Catalytic activity	3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe(2+) ion By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from direct assay. Source: MGI iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000064373
Sites
	Metal binding	47	1	Iron; catalytic By similarity
	Metal binding	53	1	Iron; catalytic By similarity
	Metal binding	91	1	Iron; catalytic By similarity
	Binding site	43	1	Dioxygen By similarity
	Binding site	53	1	Substrate By similarity
	Binding site	95	1	Substrate By similarity
	Binding site	105	1	Substrate By similarity
Amino acid modifications
	Modified residue	9	1	Phosphoserine

Sequences

	Sequence		Length	Mass (Da)
	Q78JT3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: CD8A706EE264B4CD	FASTA	286	32,804
	10 20 30 40 50 60 MERRVRVKSW VEENRASFQP PVCNKLMHQE QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 70 80 90 100 110 120 DMILRVLEQG QHRDVPIRQG EIFLLPARVP HSPQRFANTM GLVIERRRLE SELDGLRYYV 130 140 150 160 170 180 GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH SEQYRTGKPN PDQLLKELPF PLNTRSIMKP 190 200 210 220 230 240 MSLKAWLDGH SRELQAGTSL SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQQEGSSKVT 250 260 270 280 MGGQCIALAP DDSLLVPAGT SYVWERAQGS VALSVTQDPA RKKPWW

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[2]	"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis." Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H. J. Proteome Res. 7:3957-3967(2008) [PubMed: 18630941] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC012872 mRNA. Translation: AAH12872.1. BC094021 mRNA. Translation: AAH94021.1.
RefSeq	NP_079601.1.
UniGene	Mm.30100
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q78JT3.
Genome annotation databases
Ensembl	ENSMUSG00000000673. Mus musculus. [Contig view]
GeneID	107766.
KEGG	mmu:107766.
Organism-specific databases
MGI	MGI:1349444. Haao.
Phylogenomic databases
HOGENOM	Q78JT3.
HOVERGEN	Q78JT3.
Gene expression databases
ArrayExpress	Q78JT3.
CleanEx	MM_HAAO.
GermOnline	ENSMUSG00000000673. Mus musculus.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
PIRSF	PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	359412.
SOURCE	Search...

Entry information

Entry name

3HAO_MOUSE

Accession

Primary (citable) accession number: Q78JT3
Secondary accession number(s): Q52L88

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)