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Protein

F-box only protein 22

Gene

Fbxo22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.1 Publication

GO - Biological processi

  • cellular response to starvation Source: MGI
  • nucleocytoplasmic transport Source: MGI
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  • protein polyubiquitination Source: MGI
  • regulation of myotube differentiation Source: MGI
  • regulation of skeletal muscle fiber development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 22
Gene namesi
Name:Fbxo22
Synonyms:Fbx22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926014. Fbxo22.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • Z disc Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402F-box only protein 22PRO_0000119907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei193 – 1931N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ78JE5.
MaxQBiQ78JE5.
PaxDbiQ78JE5.
PRIDEiQ78JE5.

PTM databases

iPTMnetiQ78JE5.
PhosphoSiteiQ78JE5.

Expressioni

Gene expression databases

BgeeiQ78JE5.
CleanExiMM_FBXO22.
ExpressionAtlasiQ78JE5. baseline and differential.
GenevisibleiQ78JE5. MM.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034859.

Structurei

3D structure databases

ProteinModelPortaliQ78JE5.
SMRiQ78JE5. Positions 26-57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 7053F-boxAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiENOG410IQPW. Eukaryota.
ENOG4110X7S. LUCA.
GeneTreeiENSGT00390000013049.
HOGENOMiHOG000285967.
HOVERGENiHBG051570.
InParanoidiQ78JE5.
KOiK10302.
OMAiCCKVGAS.
OrthoDBiEOG72G17J.
PhylomeDBiQ78JE5.
TreeFamiTF328809.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR019494. FIST_C.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF10442. FIST_C. 1 hit.
[Graphical view]
SMARTiSM01204. FIST_C. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q78JE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGGGGGV SSSTDPRSTY VLSNLAEVVE RVFTFLPAKA LLRVAGVCRL
60 70 80 90 100
WRECVRRVLR THRSVTWISA GVAEAGHLEG HCLVRVVAEA LENVRILPQT
110 120 130 140 150
VLYMADSETF ISLEECRGHK RARKRTTMET ACALEKLFPK QCQVLGIVTP
160 170 180 190 200
GIVVTPMGSG SNRPQEIEIG ESGFALLFPQ IEGIKIQPFH FIKDSKNLTL
210 220 230 240 250
ERHQLTEVGL LDNPELRVVL VFGYNCCKVG ASNYLHRVVS TFSDMNIILA
260 270 280 290 300
GGQVDNLSSL TCEKNPLDID ATGVVGLSFS GHRIQSATVL LTEDVNDAKT
310 320 330 340 350
VEAAMQRLKA ANIPEQNTIG FMFACVGRGF QYYRAKGNVE ADAFRKFFPS
360 370 380 390 400
VPLFGFFGNG EIGCDRIVTG NFILRRCNEV KEEDLFHSYT TIMALVHLGT

SK
Length:402
Mass (Da):44,203
Last modified:March 15, 2005 - v2
Checksum:iA13037A4733583B7
GO

Sequence cautioni

The sequence AAH18273.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018273 mRNA. Translation: AAH18273.1. Different initiation.
CCDSiCCDS23202.2.
RefSeqiNP_082325.2. NM_028049.2.
XP_006511522.1. XM_006511459.2.
UniGeneiMm.276429.
Mm.443874.
Mm.487489.

Genome annotation databases

EnsembliENSMUST00000034859; ENSMUSP00000034859; ENSMUSG00000032309.
GeneIDi71999.
KEGGimmu:71999.
UCSCiuc009psc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018273 mRNA. Translation: AAH18273.1. Different initiation.
CCDSiCCDS23202.2.
RefSeqiNP_082325.2. NM_028049.2.
XP_006511522.1. XM_006511459.2.
UniGeneiMm.276429.
Mm.443874.
Mm.487489.

3D structure databases

ProteinModelPortaliQ78JE5.
SMRiQ78JE5. Positions 26-57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034859.

PTM databases

iPTMnetiQ78JE5.
PhosphoSiteiQ78JE5.

Proteomic databases

EPDiQ78JE5.
MaxQBiQ78JE5.
PaxDbiQ78JE5.
PRIDEiQ78JE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034859; ENSMUSP00000034859; ENSMUSG00000032309.
GeneIDi71999.
KEGGimmu:71999.
UCSCiuc009psc.1. mouse.

Organism-specific databases

CTDi26263.
MGIiMGI:1926014. Fbxo22.

Phylogenomic databases

eggNOGiENOG410IQPW. Eukaryota.
ENOG4110X7S. LUCA.
GeneTreeiENSGT00390000013049.
HOGENOMiHOG000285967.
HOVERGENiHBG051570.
InParanoidiQ78JE5.
KOiK10302.
OMAiCCKVGAS.
OrthoDBiEOG72G17J.
PhylomeDBiQ78JE5.
TreeFamiTF328809.

Miscellaneous databases

ChiTaRSiFbxo22. mouse.
NextBioi335186.
PROiQ78JE5.
SOURCEiSearch...

Gene expression databases

BgeeiQ78JE5.
CleanExiMM_FBXO22.
ExpressionAtlasiQ78JE5. baseline and differential.
GenevisibleiQ78JE5. MM.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR019494. FIST_C.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF10442. FIST_C. 1 hit.
[Graphical view]
SMARTiSM01204. FIST_C. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung and Testis.
  3. "F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo."
    Spaich S., Will R.D., Just S., Spaich S., Kuhn C., Frank D., Berger I.M., Wiemann S., Korn B., Koegl M., Backs J., Katus H.A., Rottbauer W., Frey N.
    Circ. Res. 111:1504-1516(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Heart.

Entry informationi

Entry nameiFBX22_MOUSE
AccessioniPrimary (citable) accession number: Q78JE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 11, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.