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Protein

Zinc transporter ZIP4

Gene

Slc39a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular response to zinc ion starvation Source: MGI
  • cellular zinc ion homeostasis Source: MGI
  • zinc II ion transmembrane import Source: GO_Central
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP4
Alternative name(s):
Activated in W/Wv mouse stomach 2
Short name:
mAWMS2
Solute carrier family 39 member 4
Zrt- and Irt-like protein 4
Short name:
ZIP-4
Gene namesi
Name:Slc39a4
Synonyms:Zip4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1919277. Slc39a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 337ExtracellularSequence analysisAdd BLAST315
Transmembranei338 – 358Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini359 – 376CytoplasmicSequence analysisAdd BLAST18
Transmembranei377 – 397Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini398 – 420ExtracellularSequence analysisAdd BLAST23
Transmembranei421 – 441Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini442 – 571CytoplasmicSequence analysisAdd BLAST130
Transmembranei572 – 592Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini593 – 599ExtracellularSequence analysis7
Transmembranei600 – 620Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini621 – 630CytoplasmicSequence analysis10
Transmembranei631 – 651Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini652 – 660ExtracellularSequence analysis9

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • endosome Source: MGI
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
  • recycling endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004262123 – 660Zinc transporter ZIP4Add BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi657N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ78IQ7.
PRIDEiQ78IQ7.

PTM databases

iPTMnetiQ78IQ7.
PhosphoSitePlusiQ78IQ7.
SwissPalmiQ78IQ7.

Expressioni

Tissue specificityi

Highly expressed in the small intestine and embryonic visceral yolk sac. Weakly expressed in the stomach and liver. Found to the apical surface of enterocytes and visceral endoderm cells during zinc deficiency.1 Publication

Inductioni

Up-regulated under conditions of dietary zinc deficiency. Down-regulated under conditions of dietary zinc excess.1 Publication

Gene expression databases

BgeeiENSMUSG00000063354.
GenevisibleiQ78IQ7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073134.

Structurei

3D structure databases

ProteinModelPortaliQ78IQ7.
SMRiQ78IQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi223 – 269His-richAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG062532.
InParanoidiQ78IQ7.
KOiK14710.
OMAiFVFRQHS.
OrthoDBiEOG091G04FT.
PhylomeDBiQ78IQ7.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q78IQ7-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPKSVTQGL VLALLVGTVA VARPRNLLSL LALGQGALDR LELDGLLNTL
60 70 80 90 100
VARVHCTDGP CEKCLSVENV LALGKPDKPQ PAPESVLESR HIIYLSAAAA
110 120 130 140 150
LYLNNPEKTC KDIQAGLLAS HVDDYLATLE SPEAMTLGLS QLLQKIEAHA
160 170 180 190 200
ASQPTGEKTC VDLPQLLEEA EAAGVSKSAG LVLTALLDHV INGSCFQGLP
210 220 230 240 250
SPQYFVDFVF RLHSSDPPNI TLHELENLMH HLGVGGEDHS DHDDHGDHAD
260 270 280 290 300
HSHPDRKASH QDSELHTPHN SNSSVWDTLC LSAKDIMAVY GLSEEAGVSP
310 320 330 340 350
QAWAQLTPAL VQQQLSGACS PYPTIRIQDQ LSQTERYLYG SLATLLICLC
360 370 380 390 400
AVFGLLLLTC AKCSTATHYI MQTFLSLAVG ALTGDALLHL IPKVLGLHTH
410 420 430 440 450
GGEGHTHEEE VGVGGQATWR LLAVLGGFYI FFLFESFFNL LLPRDQDSEK
460 470 480 490 500
DGPCSHGGHS HGISLQLAPS NLRQSKQTHE SSRSDLVAEE TPELLNPETR
510 520 530 540 550
RLRAELRLLP YLITLGDAVH NFADGLAVGA AFSSSWKTGL ATSLAVFCHE
560 570 580 590 600
LPHELGDFAA LLHAGLSVKR ALLLNLASAL TAFAGLYVAL AVGVGEEGEA
610 620 630 640 650
WILAVATGLF LYVALCDMLP AMMNVRDQRP WLLFLLHNVG LLGGWTVLLL
660
LSLYEDNITF
Note: More abundant.
Length:660
Mass (Da):71,063
Last modified:July 5, 2004 - v1
Checksum:iCA7236080C81B7BE
GO
Isoform 2 (identifier: Q78IQ7-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-63: NTLVARVHCTDGPCEK → MPGRLSLAQILSVCPQ

Show »
Length:613
Mass (Da):66,171
Checksum:i87505A21C489E2A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti431 – 435FFLFE → RPRVR (Ref. 4) Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0159131 – 47Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_01591448 – 63NTLVA…GPCEK → MPGRLSLAQILSVCPQ in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146977 mRNA. Translation: BAE27581.1.
AK147107 mRNA. Translation: BAE27679.1.
BC023498 mRNA. Translation: AAH23498.1.
AB052762 mRNA. Translation: BAC53795.1.
CCDSiCCDS27578.1. [Q78IQ7-1]
RefSeqiNP_082340.1. NM_028064.2. [Q78IQ7-1]
UniGeneiMm.276829.

Genome annotation databases

EnsembliENSMUST00000073428; ENSMUSP00000073134; ENSMUSG00000063354. [Q78IQ7-1]
GeneIDi72027.
KEGGimmu:72027.
UCSCiuc007wlb.1. mouse. [Q78IQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146977 mRNA. Translation: BAE27581.1.
AK147107 mRNA. Translation: BAE27679.1.
BC023498 mRNA. Translation: AAH23498.1.
AB052762 mRNA. Translation: BAC53795.1.
CCDSiCCDS27578.1. [Q78IQ7-1]
RefSeqiNP_082340.1. NM_028064.2. [Q78IQ7-1]
UniGeneiMm.276829.

3D structure databases

ProteinModelPortaliQ78IQ7.
SMRiQ78IQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073134.

PTM databases

iPTMnetiQ78IQ7.
PhosphoSitePlusiQ78IQ7.
SwissPalmiQ78IQ7.

Proteomic databases

PaxDbiQ78IQ7.
PRIDEiQ78IQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073428; ENSMUSP00000073134; ENSMUSG00000063354. [Q78IQ7-1]
GeneIDi72027.
KEGGimmu:72027.
UCSCiuc007wlb.1. mouse. [Q78IQ7-1]

Organism-specific databases

CTDi55630.
MGIiMGI:1919277. Slc39a4.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG062532.
InParanoidiQ78IQ7.
KOiK14710.
OMAiFVFRQHS.
OrthoDBiEOG091G04FT.
PhylomeDBiQ78IQ7.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

PROiQ78IQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063354.
GenevisibleiQ78IQ7. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A4_MOUSE
AccessioniPrimary (citable) accession number: Q78IQ7
Secondary accession number(s): Q8CHL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.