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Protein

Zinc transporter ZIP4

Gene

Slc39a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular response to zinc ion starvation Source: MGI
  • cellular zinc ion homeostasis Source: MGI
  • zinc II ion transmembrane transport Source: MGI
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP4
Alternative name(s):
Activated in W/Wv mouse stomach 2
Short name:
mAWMS2
Solute carrier family 39 member 4
Zrt- and Irt-like protein 4
Short name:
ZIP-4
Gene namesi
Name:Slc39a4
Synonyms:Zip4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1919277. Slc39a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 337315ExtracellularSequence analysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini359 – 37618CytoplasmicSequence analysisAdd
BLAST
Transmembranei377 – 39721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini398 – 42023ExtracellularSequence analysisAdd
BLAST
Transmembranei421 – 44121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini442 – 571130CytoplasmicSequence analysisAdd
BLAST
Transmembranei572 – 59221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini593 – 5997ExtracellularSequence analysis
Transmembranei600 – 62021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini621 – 63010CytoplasmicSequence analysis
Transmembranei631 – 65121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini652 – 6609ExtracellularSequence analysis

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • endosome Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • recycling endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 660638Zinc transporter ZIP4PRO_0000042621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ78IQ7.
PaxDbiQ78IQ7.
PRIDEiQ78IQ7.

PTM databases

iPTMnetiQ78IQ7.
PhosphoSiteiQ78IQ7.
SwissPalmiQ78IQ7.

Expressioni

Tissue specificityi

Highly expressed in the small intestine and embryonic visceral yolk sac. Weakly expressed in the stomach and liver. Found to the apical surface of enterocytes and visceral endoderm cells during zinc deficiency.1 Publication

Inductioni

Up-regulated under conditions of dietary zinc deficiency. Down-regulated under conditions of dietary zinc excess.1 Publication

Gene expression databases

BgeeiQ78IQ7.
GenevisibleiQ78IQ7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073134.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 26947His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG062532.
InParanoidiQ78IQ7.
KOiK14710.
OMAiFVFRQHS.
OrthoDBiEOG744T95.
PhylomeDBiQ78IQ7.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q78IQ7-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPKSVTQGL VLALLVGTVA VARPRNLLSL LALGQGALDR LELDGLLNTL
60 70 80 90 100
VARVHCTDGP CEKCLSVENV LALGKPDKPQ PAPESVLESR HIIYLSAAAA
110 120 130 140 150
LYLNNPEKTC KDIQAGLLAS HVDDYLATLE SPEAMTLGLS QLLQKIEAHA
160 170 180 190 200
ASQPTGEKTC VDLPQLLEEA EAAGVSKSAG LVLTALLDHV INGSCFQGLP
210 220 230 240 250
SPQYFVDFVF RLHSSDPPNI TLHELENLMH HLGVGGEDHS DHDDHGDHAD
260 270 280 290 300
HSHPDRKASH QDSELHTPHN SNSSVWDTLC LSAKDIMAVY GLSEEAGVSP
310 320 330 340 350
QAWAQLTPAL VQQQLSGACS PYPTIRIQDQ LSQTERYLYG SLATLLICLC
360 370 380 390 400
AVFGLLLLTC AKCSTATHYI MQTFLSLAVG ALTGDALLHL IPKVLGLHTH
410 420 430 440 450
GGEGHTHEEE VGVGGQATWR LLAVLGGFYI FFLFESFFNL LLPRDQDSEK
460 470 480 490 500
DGPCSHGGHS HGISLQLAPS NLRQSKQTHE SSRSDLVAEE TPELLNPETR
510 520 530 540 550
RLRAELRLLP YLITLGDAVH NFADGLAVGA AFSSSWKTGL ATSLAVFCHE
560 570 580 590 600
LPHELGDFAA LLHAGLSVKR ALLLNLASAL TAFAGLYVAL AVGVGEEGEA
610 620 630 640 650
WILAVATGLF LYVALCDMLP AMMNVRDQRP WLLFLLHNVG LLGGWTVLLL
660
LSLYEDNITF
Note: More abundant.
Length:660
Mass (Da):71,063
Last modified:July 5, 2004 - v1
Checksum:iCA7236080C81B7BE
GO
Isoform 2 (identifier: Q78IQ7-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-63: NTLVARVHCTDGPCEK → MPGRLSLAQILSVCPQ

Show »
Length:613
Mass (Da):66,171
Checksum:i87505A21C489E2A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti431 – 4355FFLFE → RPRVR (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4747Missing in isoform 2. 1 PublicationVSP_015913Add
BLAST
Alternative sequencei48 – 6316NTLVA…GPCEK → MPGRLSLAQILSVCPQ in isoform 2. 1 PublicationVSP_015914Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146977 mRNA. Translation: BAE27581.1.
AK147107 mRNA. Translation: BAE27679.1.
BC023498 mRNA. Translation: AAH23498.1.
AB052762 mRNA. Translation: BAC53795.1.
CCDSiCCDS27578.1. [Q78IQ7-1]
RefSeqiNP_082340.1. NM_028064.2. [Q78IQ7-1]
UniGeneiMm.276829.

Genome annotation databases

EnsembliENSMUST00000073428; ENSMUSP00000073134; ENSMUSG00000063354. [Q78IQ7-1]
GeneIDi72027.
KEGGimmu:72027.
UCSCiuc007wlb.1. mouse. [Q78IQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146977 mRNA. Translation: BAE27581.1.
AK147107 mRNA. Translation: BAE27679.1.
BC023498 mRNA. Translation: AAH23498.1.
AB052762 mRNA. Translation: BAC53795.1.
CCDSiCCDS27578.1. [Q78IQ7-1]
RefSeqiNP_082340.1. NM_028064.2. [Q78IQ7-1]
UniGeneiMm.276829.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073134.

PTM databases

iPTMnetiQ78IQ7.
PhosphoSiteiQ78IQ7.
SwissPalmiQ78IQ7.

Proteomic databases

MaxQBiQ78IQ7.
PaxDbiQ78IQ7.
PRIDEiQ78IQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073428; ENSMUSP00000073134; ENSMUSG00000063354. [Q78IQ7-1]
GeneIDi72027.
KEGGimmu:72027.
UCSCiuc007wlb.1. mouse. [Q78IQ7-1]

Organism-specific databases

CTDi55630.
MGIiMGI:1919277. Slc39a4.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG062532.
InParanoidiQ78IQ7.
KOiK14710.
OMAiFVFRQHS.
OrthoDBiEOG744T95.
PhylomeDBiQ78IQ7.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

PROiQ78IQ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ78IQ7.
GenevisibleiQ78IQ7. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice."
    Dufner-Beattie J., Wang F., Kuo Y.-M., Gitschier J., Eide D., Andrews G.K.
    J. Biol. Chem. 278:33474-33481(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  4. "Isolation and characterization of novel human and mouse genes, which are expressed in the digestive tract."
    Daigo Y., Takayama I., Fujino M.A.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 431-660.
  5. "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane."
    Kim B.-E., Wang F., Dufner-Beattie J., Andrews G.K., Eide D.J., Petris M.J.
    J. Biol. Chem. 279:4523-4530(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiS39A4_MOUSE
AccessioniPrimary (citable) accession number: Q78IQ7
Secondary accession number(s): Q8CHL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.