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Protein

MICOS complex subunit Mic27

Gene

Apool

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit Mic27
Alternative name(s):
Apolipoprotein O-like
Protein FAM121A
Gene namesi
Name:Apool
Synonyms:Fam121a, Mic27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1915367. Apool.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 110Mitochondrial intermembraneSequence analysisAdd BLAST83
Transmembranei111 – 129HelicalSequence analysisAdd BLAST19
Topological domaini130 – 137Mitochondrial matrixSequence analysis8
Transmembranei138 – 155HelicalSequence analysisAdd BLAST18
Topological domaini156 – 265Mitochondrial intermembraneSequence analysisAdd BLAST110

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000004205428 – 265MICOS complex subunit Mic27Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ78IK4.
MaxQBiQ78IK4.
PaxDbiQ78IK4.
PeptideAtlasiQ78IK4.
PRIDEiQ78IK4.

PTM databases

iPTMnetiQ78IK4.
PhosphoSitePlusiQ78IK4.
SwissPalmiQ78IK4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025525.
CleanExiMM_APOOL.
ExpressionAtlasiQ78IK4. baseline and differential.
GenevisibleiQ78IK4. MM.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with MINOS1/MIC10, IMMT/MIC60 and APOO/MIC23/MIC26.By similarity

Protein-protein interaction databases

IntActiQ78IK4. 4 interactors.
MINTiMINT-1860925.
STRINGi10090.ENSMUSP00000026599.

Structurei

3D structure databases

ProteinModelPortaliQ78IK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4798. Eukaryota.
ENOG4112AZQ. LUCA.
GeneTreeiENSGT00530000063666.
HOGENOMiHOG000034010.
HOVERGENiHBG055885.
InParanoidiQ78IK4.
OMAiRYIGWCK.
OrthoDBiEOG091G0MR4.
PhylomeDBiQ78IK4.
TreeFamiTF315313.

Family and domain databases

InterProiView protein in InterPro
IPR019166. MIC26/MIC27.
IPR033182. MIC26/MIC27_animal.
PANTHERiPTHR14564. PTHR14564. 1 hit.
PfamiView protein in Pfam
PF09769. ApoO. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78IK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFRMGKLT TIPAGLIYAS INVRLAKEEE PKKQLVRPDQ LPIYTAPPLH
60 70 80 90 100
SKYVEEQPGN LQRGFASIRT TTVYYIGWCK SIYLFMKNGV MDTVQFGKDA
110 120 130 140 150
YVYLKNPPQD FLPKMGVITA SGLAGLLSAR KGSRFKKIAY PLGLATLGAT
160 170 180 190 200
VCYPAQSVII AKITGKKAYA TSQQIFQAIK SLWTQKSENE SLPEPKEESK
210 220 230 240 250
EGRSDEIHAS LPDLKHSVSL PKELASATVI KSESTSGTTQ FIPDPKLMDH
260
GQSHPDDKDM YSTRS
Length:265
Mass (Da):29,261
Last modified:July 5, 2004 - v1
Checksum:i3DBAFD5D0AA3DC78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024334 mRNA. Translation: AAH24334.1.
CCDSiCCDS30359.1.
RefSeqiNP_080841.1. NM_026565.3.
UniGeneiMm.161014.

Genome annotation databases

EnsembliENSMUST00000026599; ENSMUSP00000026599; ENSMUSG00000025525.
GeneIDi68117.
KEGGimmu:68117.
UCSCiuc009udh.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMIC27_MOUSE
AccessioniPrimary (citable) accession number: Q78IK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families