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Protein

Up-regulated during skeletal muscle growth protein 5

Gene

Usmg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in maintaining the ATP synthase population in mitochondria.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulated during skeletal muscle growth protein 5
Alternative name(s):
Diabetes-associated protein in insulin-sensitive tissues
Gene namesi
Name:Usmg5
Synonyms:Dapit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891435. Usmg5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4523HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 5857Up-regulated during skeletal muscle growth protein 5PRO_0000231579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161N6-acetyllysineCombined sources
Modified residuei17 – 171N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ78IK2.
MaxQBiQ78IK2.
PaxDbiQ78IK2.
PeptideAtlasiQ78IK2.
PRIDEiQ78IK2.
TopDownProteomicsiQ78IK2.

PTM databases

iPTMnetiQ78IK2.
PhosphoSiteiQ78IK2.

Expressioni

Gene expression databases

BgeeiQ78IK2.
CleanExiMM_USMG5.
GenevisibleiQ78IK2. MM.

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.By similarity

Protein-protein interaction databases

BioGridi211501. 4 interactions.
IntActiQ78IK2. 3 interactions.
STRINGi10090.ENSMUSP00000093713.

Structurei

3D structure databases

ProteinModelPortaliQ78IK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2ST. Eukaryota.
ENOG410XXHD. LUCA.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ78IK2.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG7673FB.
PhylomeDBiQ78IK2.
TreeFamiTF324671.

Family and domain databases

InterProiIPR009125. DAPIT.
[Graphical view]
PRINTSiPR01821. DAPIT.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78IK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAESDGQF QFTGIKKYFN SYTLTGRMNC VLATYGGIAL LVLYFKLRPK

KTPAVKAT
Length:58
Mass (Da):6,382
Last modified:July 5, 2004 - v1
Checksum:i7CE34D192253564D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51E → K in CAC03620 (Ref. 1) Curated
Sequence conflicti27 – 271R → K in CAC03620 (Ref. 1) Curated
Sequence conflicti55 – 551V → A in CAC03620 (Ref. 1) Curated
Sequence conflicti58 – 581T → TMDFEMSDLTC in CAC03620 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290947 mRNA. Translation: CAC03620.1.
BC087919 mRNA. Translation: AAH87919.1.
CCDSiCCDS38014.1.
RefSeqiNP_075700.2. NM_023211.4.
XP_006543933.1. XM_006543870.1.
UniGeneiMm.29722.

Genome annotation databases

EnsembliENSMUST00000096014; ENSMUSP00000093713; ENSMUSG00000071528.
GeneIDi102642507.
66477.
KEGGimmu:102642507.
mmu:66477.
UCSCiuc008huo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290947 mRNA. Translation: CAC03620.1.
BC087919 mRNA. Translation: AAH87919.1.
CCDSiCCDS38014.1.
RefSeqiNP_075700.2. NM_023211.4.
XP_006543933.1. XM_006543870.1.
UniGeneiMm.29722.

3D structure databases

ProteinModelPortaliQ78IK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211501. 4 interactions.
IntActiQ78IK2. 3 interactions.
STRINGi10090.ENSMUSP00000093713.

PTM databases

iPTMnetiQ78IK2.
PhosphoSiteiQ78IK2.

Proteomic databases

EPDiQ78IK2.
MaxQBiQ78IK2.
PaxDbiQ78IK2.
PeptideAtlasiQ78IK2.
PRIDEiQ78IK2.
TopDownProteomicsiQ78IK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096014; ENSMUSP00000093713; ENSMUSG00000071528.
GeneIDi102642507.
66477.
KEGGimmu:102642507.
mmu:66477.
UCSCiuc008huo.1. mouse.

Organism-specific databases

CTDi84833.
MGIiMGI:1891435. Usmg5.

Phylogenomic databases

eggNOGiENOG410J2ST. Eukaryota.
ENOG410XXHD. LUCA.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ78IK2.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG7673FB.
PhylomeDBiQ78IK2.
TreeFamiTF324671.

Miscellaneous databases

PROiQ78IK2.
SOURCEiSearch...

Gene expression databases

BgeeiQ78IK2.
CleanExiMM_USMG5.
GenevisibleiQ78IK2. MM.

Family and domain databases

InterProiIPR009125. DAPIT.
[Graphical view]
PRINTSiPR01821. DAPIT.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterisation of genes expressed in response to active stretch of skeletal muscle."
    Sadusky T.J., Kemp T.J.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen and Testis.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-16 AND LYS-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUSMG5_MOUSE
AccessioniPrimary (citable) accession number: Q78IK2
Secondary accession number(s): Q9ER48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.