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Protein

Up-regulated during skeletal muscle growth protein 5

Gene

Usmg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in maintaining the ATP synthase population in mitochondria.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulated during skeletal muscle growth protein 5
Alternative name(s):
Diabetes-associated protein in insulin-sensitive tissues
Gene namesi
Name:Usmg5
Synonyms:Dapit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891435. Usmg5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrion Source: UniProtKB

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002315792 – 58Up-regulated during skeletal muscle growth protein 5Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16N6-acetyllysineCombined sources1
Modified residuei17N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ78IK2.
MaxQBiQ78IK2.
PaxDbiQ78IK2.
PeptideAtlasiQ78IK2.
PRIDEiQ78IK2.
TopDownProteomicsiQ78IK2.

PTM databases

iPTMnetiQ78IK2.
PhosphoSitePlusiQ78IK2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071528.
CleanExiMM_USMG5.
GenevisibleiQ78IK2. MM.

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.By similarity

Protein-protein interaction databases

BioGridi211501. 4 interactors.
IntActiQ78IK2. 3 interactors.
STRINGi10090.ENSMUSP00000093713.

Structurei

3D structure databases

ProteinModelPortaliQ78IK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2ST. Eukaryota.
ENOG410XXHD. LUCA.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ78IK2.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG091G1870.
PhylomeDBiQ78IK2.
TreeFamiTF324671.

Family and domain databases

InterProiView protein in InterPro
IPR009125. DAPIT.
PRINTSiPR01821. DAPIT.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78IK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAESDGQF QFTGIKKYFN SYTLTGRMNC VLATYGGIAL LVLYFKLRPK

KTPAVKAT
Length:58
Mass (Da):6,382
Last modified:July 5, 2004 - v1
Checksum:i7CE34D192253564D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5E → K in CAC03620 (Ref. 1) Curated1
Sequence conflicti27R → K in CAC03620 (Ref. 1) Curated1
Sequence conflicti55V → A in CAC03620 (Ref. 1) Curated1
Sequence conflicti58T → TMDFEMSDLTC in CAC03620 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290947 mRNA. Translation: CAC03620.1.
BC087919 mRNA. Translation: AAH87919.1.
CCDSiCCDS38014.1.
RefSeqiNP_075700.2. NM_023211.4.
UniGeneiMm.29722.

Genome annotation databases

EnsembliENSMUST00000096014; ENSMUSP00000093713; ENSMUSG00000071528.
GeneIDi66477.
KEGGimmu:66477.
UCSCiuc008huo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290947 mRNA. Translation: CAC03620.1.
BC087919 mRNA. Translation: AAH87919.1.
CCDSiCCDS38014.1.
RefSeqiNP_075700.2. NM_023211.4.
UniGeneiMm.29722.

3D structure databases

ProteinModelPortaliQ78IK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211501. 4 interactors.
IntActiQ78IK2. 3 interactors.
STRINGi10090.ENSMUSP00000093713.

PTM databases

iPTMnetiQ78IK2.
PhosphoSitePlusiQ78IK2.

Proteomic databases

EPDiQ78IK2.
MaxQBiQ78IK2.
PaxDbiQ78IK2.
PeptideAtlasiQ78IK2.
PRIDEiQ78IK2.
TopDownProteomicsiQ78IK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096014; ENSMUSP00000093713; ENSMUSG00000071528.
GeneIDi66477.
KEGGimmu:66477.
UCSCiuc008huo.1. mouse.

Organism-specific databases

CTDi84833.
MGIiMGI:1891435. Usmg5.

Phylogenomic databases

eggNOGiENOG410J2ST. Eukaryota.
ENOG410XXHD. LUCA.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ78IK2.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG091G1870.
PhylomeDBiQ78IK2.
TreeFamiTF324671.

Miscellaneous databases

PROiQ78IK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071528.
CleanExiMM_USMG5.
GenevisibleiQ78IK2. MM.

Family and domain databases

InterProiView protein in InterPro
IPR009125. DAPIT.
PRINTSiPR01821. DAPIT.
ProtoNetiSearch...

Entry informationi

Entry nameiUSMG5_MOUSE
AccessioniPrimary (citable) accession number: Q78IK2
Secondary accession number(s): Q9ER48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.