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Protein

Up-regulated during skeletal muscle growth protein 5

Gene

Usmg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in maintaining the ATP synthase population in mitochondria.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulated during skeletal muscle growth protein 5
Alternative name(s):
Diabetes-associated protein in insulin-sensitive tissues
Gene namesi
Name:Usmg5
Synonyms:Dapit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891435. Usmg5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002315792 – 58Up-regulated during skeletal muscle growth protein 5Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16N6-acetyllysineCombined sources1
Modified residuei17N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ78IK2.
MaxQBiQ78IK2.
PaxDbiQ78IK2.
PeptideAtlasiQ78IK2.
PRIDEiQ78IK2.
TopDownProteomicsiQ78IK2.

PTM databases

iPTMnetiQ78IK2.
PhosphoSitePlusiQ78IK2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071528.
CleanExiMM_USMG5.
GenevisibleiQ78IK2. MM.

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.By similarity

Protein-protein interaction databases

BioGridi211501. 4 interactors.
IntActiQ78IK2. 3 interactors.
STRINGi10090.ENSMUSP00000093713.

Structurei

3D structure databases

ProteinModelPortaliQ78IK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2ST. Eukaryota.
ENOG410XXHD. LUCA.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ78IK2.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG091G1870.
PhylomeDBiQ78IK2.
TreeFamiTF324671.

Family and domain databases

InterProiIPR009125. DAPIT.
[Graphical view]
PRINTSiPR01821. DAPIT.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78IK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAESDGQF QFTGIKKYFN SYTLTGRMNC VLATYGGIAL LVLYFKLRPK

KTPAVKAT
Length:58
Mass (Da):6,382
Last modified:July 5, 2004 - v1
Checksum:i7CE34D192253564D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5E → K in CAC03620 (Ref. 1) Curated1
Sequence conflicti27R → K in CAC03620 (Ref. 1) Curated1
Sequence conflicti55V → A in CAC03620 (Ref. 1) Curated1
Sequence conflicti58T → TMDFEMSDLTC in CAC03620 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290947 mRNA. Translation: CAC03620.1.
BC087919 mRNA. Translation: AAH87919.1.
CCDSiCCDS38014.1.
RefSeqiNP_075700.2. NM_023211.4.
UniGeneiMm.29722.

Genome annotation databases

EnsembliENSMUST00000096014; ENSMUSP00000093713; ENSMUSG00000071528.
GeneIDi66477.
KEGGimmu:66477.
UCSCiuc008huo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290947 mRNA. Translation: CAC03620.1.
BC087919 mRNA. Translation: AAH87919.1.
CCDSiCCDS38014.1.
RefSeqiNP_075700.2. NM_023211.4.
UniGeneiMm.29722.

3D structure databases

ProteinModelPortaliQ78IK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211501. 4 interactors.
IntActiQ78IK2. 3 interactors.
STRINGi10090.ENSMUSP00000093713.

PTM databases

iPTMnetiQ78IK2.
PhosphoSitePlusiQ78IK2.

Proteomic databases

EPDiQ78IK2.
MaxQBiQ78IK2.
PaxDbiQ78IK2.
PeptideAtlasiQ78IK2.
PRIDEiQ78IK2.
TopDownProteomicsiQ78IK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096014; ENSMUSP00000093713; ENSMUSG00000071528.
GeneIDi66477.
KEGGimmu:66477.
UCSCiuc008huo.1. mouse.

Organism-specific databases

CTDi84833.
MGIiMGI:1891435. Usmg5.

Phylogenomic databases

eggNOGiENOG410J2ST. Eukaryota.
ENOG410XXHD. LUCA.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ78IK2.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG091G1870.
PhylomeDBiQ78IK2.
TreeFamiTF324671.

Miscellaneous databases

PROiQ78IK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071528.
CleanExiMM_USMG5.
GenevisibleiQ78IK2. MM.

Family and domain databases

InterProiIPR009125. DAPIT.
[Graphical view]
PRINTSiPR01821. DAPIT.
ProtoNetiSearch...

Entry informationi

Entry nameiUSMG5_MOUSE
AccessioniPrimary (citable) accession number: Q78IK2
Secondary accession number(s): Q9ER48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.