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Protein

Glycophorin-C

Gene

Gypc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-C
Alternative name(s):
CD_antigen: CD236
Gene namesi
Name:Gypc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1098566. Gypc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini47 – 95CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • cell-cell adherens junction Source: GO_Central
  • cortical cytoskeleton Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784541 – 95Glycophorin-CAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei89PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ78HU7.
MaxQBiQ78HU7.
PaxDbiQ78HU7.
PRIDEiQ78HU7.

PTM databases

iPTMnetiQ78HU7.
PhosphoSitePlusiQ78HU7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000090523.
ExpressionAtlasiQ78HU7. baseline and differential.
GenevisibleiQ78HU7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000134317.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2G2. Eukaryota.
ENOG410YT9G. LUCA.
GeneTreeiENSGT00510000049102.
InParanoidiQ78HU7.
KOiK06576.
OMAiLRYMYRH.
OrthoDBiEOG091G1481.
PhylomeDBiQ78HU7.
TreeFamiTF337016.

Family and domain databases

InterProiView protein in InterPro
IPR003585. Neurexin-like.
SMARTiView protein in SMART
SM00294. 4.1m. 1 hit.

Sequencei

Sequence statusi: Complete.

Q78HU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPVSKPPP ELLEPNPGKS YGIMEIAIIA AVITAVALVL VCLLFLMLRY
60 70 80 90
LYRHKGTYHT NEAKGTEFAE SADAALQSDP ALQDAGDTSK KEYFI
Length:95
Mass (Da):10,329
Last modified:December 16, 2008 - v2
Checksum:iBF40FA45AFDF2B46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234183 mRNA. Translation: AAP70024.1.
BC027408 mRNA. Translation: AAH27408.2.
CCDSiCCDS57118.1.
RefSeqiNP_001041672.1. NM_001048207.1.
UniGeneiMm.292145.

Genome annotation databases

EnsembliENSMUST00000174459; ENSMUSP00000134317; ENSMUSG00000090523.
GeneIDi71683.
KEGGimmu:71683.
UCSCiuc008ejk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234183 mRNA. Translation: AAP70024.1.
BC027408 mRNA. Translation: AAH27408.2.
CCDSiCCDS57118.1.
RefSeqiNP_001041672.1. NM_001048207.1.
UniGeneiMm.292145.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000134317.

PTM databases

iPTMnetiQ78HU7.
PhosphoSitePlusiQ78HU7.

Proteomic databases

EPDiQ78HU7.
MaxQBiQ78HU7.
PaxDbiQ78HU7.
PRIDEiQ78HU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000174459; ENSMUSP00000134317; ENSMUSG00000090523.
GeneIDi71683.
KEGGimmu:71683.
UCSCiuc008ejk.1. mouse.

Organism-specific databases

CTDi2995.
MGIiMGI:1098566. Gypc.

Phylogenomic databases

eggNOGiENOG410J2G2. Eukaryota.
ENOG410YT9G. LUCA.
GeneTreeiENSGT00510000049102.
InParanoidiQ78HU7.
KOiK06576.
OMAiLRYMYRH.
OrthoDBiEOG091G1481.
PhylomeDBiQ78HU7.
TreeFamiTF337016.

Miscellaneous databases

PROiPR:Q78HU7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090523.
ExpressionAtlasiQ78HU7. baseline and differential.
GenevisibleiQ78HU7. MM.

Family and domain databases

InterProiView protein in InterPro
IPR003585. Neurexin-like.
SMARTiView protein in SMART
SM00294. 4.1m. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLPC_MOUSE
AccessioniPrimary (citable) accession number: Q78HU7
Secondary accession number(s): Q6XFR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: December 16, 2008
Last modified: June 7, 2017
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.