Reviewed, UniProtKB/Swiss-Prot Q78EA7 (BMR1A_RAT)

Names and origin

Protein names

Recommended name:
    Bone morphogenetic protein receptor type-1A
    EC=2.7.11.30
Alternative name(s):
    Activin receptor-like kinase 3
      Short name=ALK-3
    Bone morphogenetic protein 4 receptor
    CD_antigen=CD292

Gene names

Name:

Bmpr1a

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 By similarity.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein serine/threonine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 532	509	Bone morphogenetic protein receptor type-1A		PRO_0000254907
Regions
	Topological domain	24 – 152	129	Extracellular Potential
	Transmembrane	153 – 176	24	Potential
	Topological domain	177 – 532	356	Cytoplasmic Potential
	Domain	204 – 233	30	GS
	Domain	234 – 525	292	Protein kinase
	Nucleotide binding	240 – 248	9	ATP By similarity
Sites
	Active site	362	1	Proton acceptor By similarity
	Binding site	261	1	ATP By similarity
Amino acid modifications
	Modified residue	215	1	Phosphoserine By similarity
	Modified residue	216	1	Phosphoserine By similarity
	Modified residue	218	1	Phosphoserine By similarity
	Modified residue	220	1	Phosphoserine By similarity
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Disulfide bond	61 ↔ 82		By similarity
	Disulfide bond	63 ↔ 67		By similarity
	Disulfide bond	76 ↔ 100		By similarity
	Disulfide bond	110 ↔ 124		By similarity
	Disulfide bond	125 ↔ 130		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q78EA7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 14ED4C03E2540A0C	FASTA	532	59,994
	10 20 30 40 50 60 MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL APEDTLPFLK 70 80 90 100 110 120 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 130 140 150 160 170 180 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS VRWLAVLISM AVCIVAMIVF SSCFCYKHYC 190 200 210 220 230 240 KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 250 260 270 280 290 300 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 310 320 330 340 350 360 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 370 380 390 400 410 420 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTRRYMAP EVLDESLSKN 430 440 450 460 470 480 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 490 500 510 520 530 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

References

[1]	"Expression of serine/threonine kinase receptors during ectopic bone formation induced by bone morphogenetic protein (BMP)." Takeda K. Kokubyo Gakkai Zasshi 61:512-526(1994) [PubMed: 7897267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP." Takeda K., Oida S., Ichijo H., Iimura T., Maruoka Y., Amagasa T., Sasaki S. Biochem. Biophys. Res. Commun. 204:203-209(1994) [PubMed: 7945360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Dental pulp.
[3]	"Expression pattern of bone morphogenetic protein 4 receptor in embryo and adult rat." Ikeda T., Takahashi H. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S75359 mRNA. Translation: AAB33865.1. D38082 mRNA. Translation: BAA07275.1. D17667 mRNA. Translation: BAA04549.1.
PIR	JC2387.
RefSeq	NP_110476.1.
UniGene	Rn.88925
3D structure databases
HSSP	HSSP built from PDB template 1B6C based on UniProtKB P36897.
SMR	Q78EA7. Positions 55-146.
ModBase	Search...
PTM databases
PhosphoSite	Q78EA7.
Genome annotation databases
Ensembl	ENSRNOG00000010814. Rattus norvegicus. [Contig view]
GeneID	81507.
KEGG	rno:81507.
Organism-specific databases
RGD	70989. Bmpr1a.
Phylogenomic databases
HOVERGEN	Q78EA7.
Gene expression databases
ArrayExpress	Q78EA7.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	614971.

Entry information

Entry name

BMR1A_RAT

Accession

Primary (citable) accession number: Q78EA7
Secondary accession number(s): Q64308

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)