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Protein

Bone morphogenetic protein receptor type-1A

Gene

Bmpr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 (By similarity).By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei261 – 2611ATPPROSITE-ProRule annotation
Active sitei362 – 3621Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2489ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  5. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. cartilage development Source: Ensembl
  3. developmental growth Source: Ensembl
  4. dorsal/ventral axis specification Source: Ensembl
  5. ectoderm development Source: Ensembl
  6. embryonic digit morphogenesis Source: Ensembl
  7. embryonic organ development Source: Ensembl
  8. endocardial cushion formation Source: Ensembl
  9. heart formation Source: Ensembl
  10. hindlimb morphogenesis Source: Ensembl
  11. immune response Source: Ensembl
  12. in utero embryonic development Source: Ensembl
  13. lateral mesoderm development Source: Ensembl
  14. lung development Source: Ensembl
  15. mesendoderm development Source: Ensembl
  16. mesoderm formation Source: Ensembl
  17. Mullerian duct regression Source: Ensembl
  18. negative regulation of neurogenesis Source: Ensembl
  19. neural crest cell development Source: Ensembl
  20. neural plate mediolateral regionalization Source: Ensembl
  21. odontogenesis of dentin-containing tooth Source: Ensembl
  22. palate development Source: Ensembl
  23. paraxial mesoderm structural organization Source: Ensembl
  24. pituitary gland development Source: Ensembl
  25. positive regulation of bone mineralization Source: Ensembl
  26. positive regulation of epithelial cell proliferation Source: Ensembl
  27. positive regulation of mesenchymal cell proliferation Source: Ensembl
  28. positive regulation of osteoblast differentiation Source: Ensembl
  29. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  30. positive regulation of SMAD protein import into nucleus Source: Ensembl
  31. positive regulation of transcription, DNA-templated Source: Ensembl
  32. regulation of lateral mesodermal cell fate specification Source: Ensembl
  33. somitogenesis Source: Ensembl
  34. stem cell maintenance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_234964. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
Short name:
BMP type-1A receptor
Short name:
BMPR-1A
Alternative name(s):
Activin receptor-like kinase 3
Short name:
ALK-3
Bone morphogenetic protein 4 receptor
CD_antigen: CD292
Gene namesi
Name:Bmpr1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi70989. Bmpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 152129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei153 – 17624HelicalSequence AnalysisAdd
BLAST
Topological domaini177 – 532356CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. dendrite Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 532509Bone morphogenetic protein receptor type-1APRO_0000254907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 82By similarity
Disulfide bondi63 ↔ 67By similarity
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi76 ↔ 100By similarity
Disulfide bondi110 ↔ 124By similarity
Disulfide bondi125 ↔ 130By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiQ78EA7.

Expressioni

Gene expression databases

GenevestigatoriQ78EA7.

Interactioni

Protein-protein interaction databases

BioGridi249504. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ78EA7.
SMRiQ78EA7. Positions 55-146, 200-528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 23330GSPROSITE-ProRule annotationAdd
BLAST
Domaini234 – 525292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1093Mediates specificity for BMP ligandBy similarity

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ78EA7.
KOiK04673.
OMAiCYNRDLE.
OrthoDBiEOG7Q8CN3.
PhylomeDBiQ78EA7.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78EA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL
60 70 80 90 100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC
110 120 130 140 150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS
160 170 180 190 200
VRWLAVLISM AVCIVAMIVF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI
210 220 230 240 250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM
260 270 280 290 300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
310 320 330 340 350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY
360 370 380 390 400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT
410 420 430 440 450
RVGTRRYMAP EVLDESLSKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV
460 470 480 490 500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM
510 520 530
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Length:532
Mass (Da):59,994
Last modified:July 5, 2004 - v1
Checksum:i14ED4C03E2540A0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75359 mRNA. Translation: AAB33865.1.
D38082 mRNA. Translation: BAA07275.1.
D17667 mRNA. Translation: BAA04549.1.
PIRiJC2387.
RefSeqiNP_110476.1. NM_030849.1.
UniGeneiRn.88925.

Genome annotation databases

EnsembliENSRNOT00000015047; ENSRNOP00000015047; ENSRNOG00000010814.
GeneIDi81507.
KEGGirno:81507.
UCSCiRGD:70989. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75359 mRNA. Translation: AAB33865.1.
D38082 mRNA. Translation: BAA07275.1.
D17667 mRNA. Translation: BAA04549.1.
PIRiJC2387.
RefSeqiNP_110476.1. NM_030849.1.
UniGeneiRn.88925.

3D structure databases

ProteinModelPortaliQ78EA7.
SMRiQ78EA7. Positions 55-146, 200-528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249504. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi1786.

PTM databases

PhosphoSiteiQ78EA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015047; ENSRNOP00000015047; ENSRNOG00000010814.
GeneIDi81507.
KEGGirno:81507.
UCSCiRGD:70989. rat.

Organism-specific databases

CTDi657.
RGDi70989. Bmpr1a.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ78EA7.
KOiK04673.
OMAiCYNRDLE.
OrthoDBiEOG7Q8CN3.
PhylomeDBiQ78EA7.
TreeFamiTF314724.

Enzyme and pathway databases

ReactomeiREACT_234964. Signaling by BMP.

Miscellaneous databases

NextBioi614971.
PROiQ78EA7.

Gene expression databases

GenevestigatoriQ78EA7.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of serine/threonine kinase receptors during ectopic bone formation induced by bone morphogenetic protein (BMP)."
    Takeda K.
    Kokubyo Gakkai Zasshi 61:512-526(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP."
    Takeda K., Oida S., Ichijo H., Iimura T., Maruoka Y., Amagasa T., Sasaki S.
    Biochem. Biophys. Res. Commun. 204:203-209(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Dental pulp.
  3. "Expression pattern of bone morphogenetic protein 4 receptor in embryo and adult rat."
    Ikeda T., Takahashi H.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiBMR1A_RAT
AccessioniPrimary (citable) accession number: Q78EA7
Secondary accession number(s): Q64308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.