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Protein

Bone morphogenetic protein receptor type-1A

Gene

Bmpr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei261ATPPROSITE-ProRule annotation1
Active sitei362Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi240 – 248ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
Short name:
BMP type-1A receptor
Short name:
BMPR-1A
Alternative name(s):
Activin receptor-like kinase 3
Short name:
ALK-3
Bone morphogenetic protein 4 receptor
CD_antigen: CD292
Gene namesi
Name:Bmpr1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi70989. Bmpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 152ExtracellularSequence analysisAdd BLAST129
Transmembranei153 – 176HelicalSequence analysisAdd BLAST24
Topological domaini177 – 532CytoplasmicSequence analysisAdd BLAST356

GO - Cellular componenti

  • caveola Source: Ensembl
  • dendrite Source: RGD
  • external side of plasma membrane Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000025490724 – 532Bone morphogenetic protein receptor type-1AAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 82By similarity
Disulfide bondi63 ↔ 67By similarity
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi76 ↔ 100By similarity
Disulfide bondi110 ↔ 124By similarity
Disulfide bondi125 ↔ 130By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ78EA7.

PTM databases

iPTMnetiQ78EA7.
PhosphoSitePlusiQ78EA7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010814.
GenevisibleiQ78EA7. RN.

Interactioni

Subunit structurei

Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation.By similarity

Protein-protein interaction databases

BioGridi249504. 1 interactor.
STRINGi10116.ENSRNOP00000015047.

Structurei

3D structure databases

ProteinModelPortaliQ78EA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 233GSPROSITE-ProRule annotationAdd BLAST30
Domaini234 – 525Protein kinasePROSITE-ProRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 109Mediates specificity for BMP ligandBy similarity3

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ78EA7.
KOiK04673.
OMAiKHYCKSM.
OrthoDBiEOG091G0BIU.
PhylomeDBiQ78EA7.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78EA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL
60 70 80 90 100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC
110 120 130 140 150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS
160 170 180 190 200
VRWLAVLISM AVCIVAMIVF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI
210 220 230 240 250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM
260 270 280 290 300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
310 320 330 340 350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY
360 370 380 390 400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT
410 420 430 440 450
RVGTRRYMAP EVLDESLSKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV
460 470 480 490 500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM
510 520 530
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Length:532
Mass (Da):59,994
Last modified:July 5, 2004 - v1
Checksum:i14ED4C03E2540A0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75359 mRNA. Translation: AAB33865.1.
D38082 mRNA. Translation: BAA07275.1.
D17667 mRNA. Translation: BAA04549.1.
PIRiJC2387.
RefSeqiNP_110476.1. NM_030849.1.
XP_017455745.1. XM_017600256.1.
UniGeneiRn.88925.

Genome annotation databases

EnsembliENSRNOT00000079554; ENSRNOP00000074885; ENSRNOG00000052469.
GeneIDi81507.
KEGGirno:81507.
UCSCiRGD:70989. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75359 mRNA. Translation: AAB33865.1.
D38082 mRNA. Translation: BAA07275.1.
D17667 mRNA. Translation: BAA04549.1.
PIRiJC2387.
RefSeqiNP_110476.1. NM_030849.1.
XP_017455745.1. XM_017600256.1.
UniGeneiRn.88925.

3D structure databases

ProteinModelPortaliQ78EA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249504. 1 interactor.
STRINGi10116.ENSRNOP00000015047.

PTM databases

iPTMnetiQ78EA7.
PhosphoSitePlusiQ78EA7.

Proteomic databases

PaxDbiQ78EA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000079554; ENSRNOP00000074885; ENSRNOG00000052469.
GeneIDi81507.
KEGGirno:81507.
UCSCiRGD:70989. rat.

Organism-specific databases

CTDi657.
RGDi70989. Bmpr1a.

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ78EA7.
KOiK04673.
OMAiKHYCKSM.
OrthoDBiEOG091G0BIU.
PhylomeDBiQ78EA7.
TreeFamiTF314724.

Enzyme and pathway databases

ReactomeiR-RNO-201451. Signaling by BMP.

Miscellaneous databases

PROiQ78EA7.

Gene expression databases

BgeeiENSRNOG00000010814.
GenevisibleiQ78EA7. RN.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMR1A_RAT
AccessioniPrimary (citable) accession number: Q78EA7
Secondary accession number(s): Q64308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.