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Q78EA7

- BMR1A_RAT

UniProt

Q78EA7 - BMR1A_RAT

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Protein
Bone morphogenetic protein receptor type-1A
Gene
Bmpr1a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 By similarity.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei261 – 2611ATP By similarity
Active sitei362 – 3621Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2489ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  5. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. Mullerian duct regression Source: Ensembl
  3. cartilage development Source: Ensembl
  4. developmental growth Source: Ensembl
  5. dorsal/ventral axis specification Source: Ensembl
  6. ectoderm development Source: Ensembl
  7. embryonic digit morphogenesis Source: Ensembl
  8. embryonic organ development Source: Ensembl
  9. endocardial cushion formation Source: Ensembl
  10. heart formation Source: Ensembl
  11. hindlimb morphogenesis Source: Ensembl
  12. immune response Source: Ensembl
  13. in utero embryonic development Source: Ensembl
  14. lateral mesoderm development Source: Ensembl
  15. lung development Source: Ensembl
  16. mesendoderm development Source: Ensembl
  17. mesoderm formation Source: Ensembl
  18. negative regulation of neurogenesis Source: Ensembl
  19. neural crest cell development Source: Ensembl
  20. neural plate mediolateral regionalization Source: Ensembl
  21. odontogenesis of dentin-containing tooth Source: Ensembl
  22. palate development Source: Ensembl
  23. paraxial mesoderm structural organization Source: Ensembl
  24. pituitary gland development Source: Ensembl
  25. positive regulation of SMAD protein import into nucleus Source: Ensembl
  26. positive regulation of bone mineralization Source: Ensembl
  27. positive regulation of epithelial cell proliferation Source: Ensembl
  28. positive regulation of mesenchymal cell proliferation Source: Ensembl
  29. positive regulation of osteoblast differentiation Source: Ensembl
  30. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  31. positive regulation of transcription, DNA-templated Source: Ensembl
  32. regulation of lateral mesodermal cell fate specification Source: Ensembl
  33. somitogenesis Source: Ensembl
  34. stem cell maintenance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
Short name:
BMP type-1A receptor
Short name:
BMPR-1A
Alternative name(s):
Activin receptor-like kinase 3
Short name:
ALK-3
Bone morphogenetic protein 4 receptor
CD_antigen: CD292
Gene namesi
Name:Bmpr1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi70989. Bmpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 152129Extracellular Reviewed prediction
Add
BLAST
Transmembranei153 – 17624Helical; Reviewed prediction
Add
BLAST
Topological domaini177 – 532356Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. dendrite Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 532509Bone morphogenetic protein receptor type-1A
PRO_0000254907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 82 By similarity
Disulfide bondi63 ↔ 67 By similarity
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi76 ↔ 100 By similarity
Disulfide bondi110 ↔ 124 By similarity
Disulfide bondi125 ↔ 130 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiQ78EA7.

Expressioni

Gene expression databases

GenevestigatoriQ78EA7.

Interactioni

Protein-protein interaction databases

BioGridi249504. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ78EA7.
SMRiQ78EA7. Positions 55-146, 200-528.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 23330GS
Add
BLAST
Domaini234 – 525292Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1093Mediates specificity for BMP ligand By similarity

Sequence similaritiesi

Contains 1 GS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110337.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiQ78EA7.
KOiK04673.
OMAiCYNRDLE.
OrthoDBiEOG7Q8CN3.
PhylomeDBiQ78EA7.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q78EA7-1 [UniParc]FASTAAdd to Basket

« Hide

MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL    50
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC 100
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS 150
VRWLAVLISM AVCIVAMIVF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI 200
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM 250
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY 350
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT 400
RVGTRRYMAP EVLDESLSKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV 450
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM 500
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532
Length:532
Mass (Da):59,994
Last modified:July 5, 2004 - v1
Checksum:i14ED4C03E2540A0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75359 mRNA. Translation: AAB33865.1.
D38082 mRNA. Translation: BAA07275.1.
D17667 mRNA. Translation: BAA04549.1.
PIRiJC2387.
RefSeqiNP_110476.1. NM_030849.1.
UniGeneiRn.88925.

Genome annotation databases

EnsembliENSRNOT00000015047; ENSRNOP00000015047; ENSRNOG00000010814.
GeneIDi81507.
KEGGirno:81507.
UCSCiRGD:70989. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S75359 mRNA. Translation: AAB33865.1 .
D38082 mRNA. Translation: BAA07275.1 .
D17667 mRNA. Translation: BAA04549.1 .
PIRi JC2387.
RefSeqi NP_110476.1. NM_030849.1.
UniGenei Rn.88925.

3D structure databases

ProteinModelPortali Q78EA7.
SMRi Q78EA7. Positions 55-146, 200-528.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249504. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi 1786.

PTM databases

PhosphoSitei Q78EA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015047 ; ENSRNOP00000015047 ; ENSRNOG00000010814 .
GeneIDi 81507.
KEGGi rno:81507.
UCSCi RGD:70989. rat.

Organism-specific databases

CTDi 657.
RGDi 70989. Bmpr1a.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110337.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi Q78EA7.
KOi K04673.
OMAi CYNRDLE.
OrthoDBi EOG7Q8CN3.
PhylomeDBi Q78EA7.
TreeFami TF314724.

Miscellaneous databases

NextBioi 614971.
PROi Q78EA7.

Gene expression databases

Genevestigatori Q78EA7.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of serine/threonine kinase receptors during ectopic bone formation induced by bone morphogenetic protein (BMP)."
    Takeda K.
    Kokubyo Gakkai Zasshi 61:512-526(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP."
    Takeda K., Oida S., Ichijo H., Iimura T., Maruoka Y., Amagasa T., Sasaki S.
    Biochem. Biophys. Res. Commun. 204:203-209(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Dental pulp.
  3. "Expression pattern of bone morphogenetic protein 4 receptor in embryo and adult rat."
    Ikeda T., Takahashi H.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiBMR1A_RAT
AccessioniPrimary (citable) accession number: Q78EA7
Secondary accession number(s): Q64308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi