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Q78EA7

- BMR1A_RAT

UniProt

Q78EA7 - BMR1A_RAT

Protein

Bone morphogenetic protein receptor type-1A

Gene

Bmpr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 By similarity.By similarity

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei261 – 2611ATPPROSITE-ProRule annotation
    Active sitei362 – 3621Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi240 – 2489ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    5. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. BMP signaling pathway Source: Ensembl
    2. cartilage development Source: Ensembl
    3. developmental growth Source: Ensembl
    4. dorsal/ventral axis specification Source: Ensembl
    5. ectoderm development Source: Ensembl
    6. embryonic digit morphogenesis Source: Ensembl
    7. embryonic organ development Source: Ensembl
    8. endocardial cushion formation Source: Ensembl
    9. heart formation Source: Ensembl
    10. hindlimb morphogenesis Source: Ensembl
    11. immune response Source: Ensembl
    12. in utero embryonic development Source: Ensembl
    13. lateral mesoderm development Source: Ensembl
    14. lung development Source: Ensembl
    15. mesendoderm development Source: Ensembl
    16. mesoderm formation Source: Ensembl
    17. Mullerian duct regression Source: Ensembl
    18. negative regulation of neurogenesis Source: Ensembl
    19. neural crest cell development Source: Ensembl
    20. neural plate mediolateral regionalization Source: Ensembl
    21. odontogenesis of dentin-containing tooth Source: Ensembl
    22. palate development Source: Ensembl
    23. paraxial mesoderm structural organization Source: Ensembl
    24. pituitary gland development Source: Ensembl
    25. positive regulation of bone mineralization Source: Ensembl
    26. positive regulation of epithelial cell proliferation Source: Ensembl
    27. positive regulation of mesenchymal cell proliferation Source: Ensembl
    28. positive regulation of osteoblast differentiation Source: Ensembl
    29. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    30. positive regulation of SMAD protein import into nucleus Source: Ensembl
    31. positive regulation of transcription, DNA-templated Source: Ensembl
    32. regulation of lateral mesodermal cell fate specification Source: Ensembl
    33. somitogenesis Source: Ensembl
    34. stem cell maintenance Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
    Short name:
    BMP type-1A receptor
    Short name:
    BMPR-1A
    Alternative name(s):
    Activin receptor-like kinase 3
    Short name:
    ALK-3
    Bone morphogenetic protein 4 receptor
    CD_antigen: CD292
    Gene namesi
    Name:Bmpr1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi70989. Bmpr1a.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. dendrite Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 532509Bone morphogenetic protein receptor type-1APRO_0000254907Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi61 ↔ 82By similarity
    Disulfide bondi63 ↔ 67By similarity
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi76 ↔ 100By similarity
    Disulfide bondi110 ↔ 124By similarity
    Disulfide bondi125 ↔ 130By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    PTM databases

    PhosphoSiteiQ78EA7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ78EA7.

    Interactioni

    Protein-protein interaction databases

    BioGridi249504. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ78EA7.
    SMRiQ78EA7. Positions 55-146, 200-528.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 152129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini177 – 532356CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei153 – 17624HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 23330GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini234 – 525292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni107 – 1093Mediates specificity for BMP ligandBy similarity

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110337.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiQ78EA7.
    KOiK04673.
    OMAiCYNRDLE.
    OrthoDBiEOG7Q8CN3.
    PhylomeDBiQ78EA7.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q78EA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL    50
    APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC 100
    MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS 150
    VRWLAVLISM AVCIVAMIVF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI 200
    PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM 250
    GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300
    SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY 350
    GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT 400
    RVGTRRYMAP EVLDESLSKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV 450
    EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM 500
    SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532
    Length:532
    Mass (Da):59,994
    Last modified:July 5, 2004 - v1
    Checksum:i14ED4C03E2540A0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75359 mRNA. Translation: AAB33865.1.
    D38082 mRNA. Translation: BAA07275.1.
    D17667 mRNA. Translation: BAA04549.1.
    PIRiJC2387.
    RefSeqiNP_110476.1. NM_030849.1.
    UniGeneiRn.88925.

    Genome annotation databases

    EnsembliENSRNOT00000015047; ENSRNOP00000015047; ENSRNOG00000010814.
    GeneIDi81507.
    KEGGirno:81507.
    UCSCiRGD:70989. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S75359 mRNA. Translation: AAB33865.1 .
    D38082 mRNA. Translation: BAA07275.1 .
    D17667 mRNA. Translation: BAA04549.1 .
    PIRi JC2387.
    RefSeqi NP_110476.1. NM_030849.1.
    UniGenei Rn.88925.

    3D structure databases

    ProteinModelPortali Q78EA7.
    SMRi Q78EA7. Positions 55-146, 200-528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249504. 1 interaction.

    Chemistry

    GuidetoPHARMACOLOGYi 1786.

    PTM databases

    PhosphoSitei Q78EA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015047 ; ENSRNOP00000015047 ; ENSRNOG00000010814 .
    GeneIDi 81507.
    KEGGi rno:81507.
    UCSCi RGD:70989. rat.

    Organism-specific databases

    CTDi 657.
    RGDi 70989. Bmpr1a.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110337.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi Q78EA7.
    KOi K04673.
    OMAi CYNRDLE.
    OrthoDBi EOG7Q8CN3.
    PhylomeDBi Q78EA7.
    TreeFami TF314724.

    Miscellaneous databases

    NextBioi 614971.
    PROi Q78EA7.

    Gene expression databases

    Genevestigatori Q78EA7.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of serine/threonine kinase receptors during ectopic bone formation induced by bone morphogenetic protein (BMP)."
      Takeda K.
      Kokubyo Gakkai Zasshi 61:512-526(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP."
      Takeda K., Oida S., Ichijo H., Iimura T., Maruoka Y., Amagasa T., Sasaki S.
      Biochem. Biophys. Res. Commun. 204:203-209(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Dental pulp.
    3. "Expression pattern of bone morphogenetic protein 4 receptor in embryo and adult rat."
      Ikeda T., Takahashi H.
      Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiBMR1A_RAT
    AccessioniPrimary (citable) accession number: Q78EA7
    Secondary accession number(s): Q64308
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3