Q78EA7 (BMR1A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein receptor type-1A
Short name=BMP type-1A receptor
Short name=BMPR-1A
EC=2.7.11.30

Alternative name(s):
Activin receptor-like kinase 3
Short name=ALK-3
Bone morphogenetic protein 4 receptor
CD_antigen=CD292

Gene names

Name:

Bmpr1a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 By similarity.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from electronic annotation. Source: Compara Mullerian duct regression Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara developmental growth Inferred from electronic annotation. Source: Compara dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara ectoderm development Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic organ development Inferred from electronic annotation. Source: Compara endocardial cushion formation Inferred from electronic annotation. Source: Compara heart formation Inferred from electronic annotation. Source: Compara hindlimb morphogenesis Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara lateral mesoderm development Inferred from electronic annotation. Source: Compara lung development Inferred from electronic annotation. Source: Compara mesendoderm development Inferred from electronic annotation. Source: Compara mesoderm formation Inferred from electronic annotation. Source: Compara negative regulation of neurogenesis Inferred from electronic annotation. Source: Compara neural crest cell development Inferred from electronic annotation. Source: Compara neural plate mediolateral regionalization Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara paraxial mesoderm structural organization Inferred from electronic annotation. Source: Compara pituitary gland development Inferred from electronic annotation. Source: Compara positive regulation of SMAD protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of lateral mesodermal cell fate specification Inferred from electronic annotation. Source: Compara somitogenesis Inferred from electronic annotation. Source: Compara stem cell maintenance Inferred from electronic annotation. Source: Compara
Cellular_component	caveola Inferred from electronic annotation. Source: Compara dendrite Inferred from direct assay PubMed 21185359. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuronal cell body Inferred from direct assay PubMed 21185359. Source: RGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: Compara transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 532	509	Bone morphogenetic protein receptor type-1A		PRO_0000254907
Regions
	Topological domain	24 – 152	129	Extracellular Potential
	Transmembrane	153 – 176	24	Helical; Potential
	Topological domain	177 – 532	356	Cytoplasmic Potential
	Domain	204 – 233	30	GS
	Domain	234 – 525	292	Protein kinase
	Nucleotide binding	240 – 248	9	ATP By similarity
	Region	107 – 109	3	Mediates specificity for BMP ligand By similarity
Sites
	Active site	362	1	Proton acceptor By similarity
	Binding site	261	1	ATP By similarity
Amino acid modifications
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Disulfide bond	61 ↔ 82		By similarity
	Disulfide bond	63 ↔ 67		By similarity
	Disulfide bond	76 ↔ 100		By similarity
	Disulfide bond	110 ↔ 124		By similarity
	Disulfide bond	125 ↔ 130		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q78EA7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 14ED4C03E2540A0C	FASTA	532	59,994
	10 20 30 40 50 60 MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL APEDTLPFLK 70 80 90 100 110 120 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 130 140 150 160 170 180 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS VRWLAVLISM AVCIVAMIVF SSCFCYKHYC 190 200 210 220 230 240 KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 250 260 270 280 290 300 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 310 320 330 340 350 360 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 370 380 390 400 410 420 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTRRYMAP EVLDESLSKN 430 440 450 460 470 480 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 490 500 510 520 530 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

References

[1]	"Expression of serine/threonine kinase receptors during ectopic bone formation induced by bone morphogenetic protein (BMP)." Takeda K. Kokubyo Gakkai Zasshi 61:512-526(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP." Takeda K., Oida S., Ichijo H., Iimura T., Maruoka Y., Amagasa T., Sasaki S. Biochem. Biophys. Res. Commun. 204:203-209(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Dental pulp.
[3]	"Expression pattern of bone morphogenetic protein 4 receptor in embryo and adult rat." Ikeda T., Takahashi H. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S75359 mRNA. Translation: AAB33865.1. D38082 mRNA. Translation: BAA07275.1. D17667 mRNA. Translation: BAA04549.1.
IPI	IPI00211618.
PIR	JC2387.
RefSeq	NP_110476.1. NM_030849.1.
UniGene	Rn.88925.
3D structure databases
HSSP	HSSP built from PDB template 1ES7 based on UniProtKB P36894.
ProteinModelPortal	Q78EA7.
SMR	Q78EA7. Positions 55-146, 200-528.
ModBase	Search...
PTM databases
PhosphoSite	Q78EA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000015047; ENSRNOP00000015047; ENSRNOG00000010814.
GeneID	81507.
KEGG	rno:81507.
UCSC	RGD:70989. rat.
Organism-specific databases
CTD	657.
RGD	70989. Bmpr1a.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076615.
HOGENOM	HOG000230587.
HOVERGEN	HBG054502.
InParanoid	Q78EA7.
KO	K04673.
OMA	LEVVCVK.
OrthoDB	EOG4F1X2X.
Gene expression databases
Genevestigator	Q78EA7.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	614971.

Entry information

Entry name

BMR1A_RAT

Accession

Primary (citable) accession number: Q78EA7
Secondary accession number(s): Q64308

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program